Photodiagnosis and Photodynamic Therapy, Год журнала: 2024, Номер unknown, С. 104435 - 104435
Опубликована: Дек. 1, 2024
To study the changes in retinal and choroidal vessels patients with coronary artery stenosis via optical coherence tomography angiography (OCTA).
Язык: Английский
Progress in Retinal and Eye Research, Год журнала: 2024, Номер 103, С. 101292 - 101292
Опубликована: Авг. 30, 2024
Optical coherence tomography angiography (OCTA) has transformed ocular vascular imaging, revealing microvascular changes linked to various systemic diseases. This review explores its applications in diabetes, hypertension, cardiovascular diseases, and neurodegenerative While OCTA provides a valuable window into the body's microvasculature, interpreting findings can be complex. Additionally, challenges exist due relative non-specificity of where observed might not unique specific disease, variations between machines, lack standardized normative database for comparison, potential image artifacts. Despite these limitations, holds immense future. The highlights promising advancements like quantitative analysis images, integration artificial intelligence faster more accurate interpretation, multi-modal imaging combining with other techniques comprehensive characterization vasculature. Furthermore, OCTA's future role personalized medicine, enabling tailored treatment plans based on individual findings, community screening programs early disease detection, longitudinal studies tracking progression over time is also discussed. In conclusion, presents significant opportunity improve our understanding management Addressing current limitations pursuing exciting directions solidify as an indispensable tool diagnosis, monitoring progression, potentially guiding decisions across health conditions.
Язык: Английский
Процитировано
11
Biomedicines, Год журнала: 2024, Номер 12(9), С. 2150 - 2150
Опубликована: Сен. 23, 2024
Cardiovascular diseases (CVDs) are a major cause of mortality globally, emphasizing the need for early detection and effective risk assessment to improve patient outcomes. Advances in oculomics, which utilize relationship between retinal microvascular changes systemic vascular health, offer promising non-invasive approach assessing CVD risk. Retinal fundus imaging optical coherence tomography/angiography (OCT/OCTA) provides critical information diagnosis, with parameters such as vessel caliber, tortuosity, branching patterns identified key biomarkers. Given large volume data generated during routine eye exams, there is growing automated tools aid diagnosis prediction. The study demonstrates that AI-driven analysis images can accurately predict cardiovascular factors, events, metabolic diseases, surpassing traditional diagnostic methods some cases. These models achieved area under curve (AUC) values ranging from 0.71 0.87, sensitivity 71% 89%, specificity 40% 70%, This highlights potential component personalized medicine, enabling more precise earlier intervention. It not only aids detecting abnormalities may precede events but also offers scalable, non-invasive, cost-effective solution widespread screening. However, article emphasizes further research standardize protocols validate clinical utility these biomarkers across different populations. By integrating oculomics into practice, healthcare providers could significantly enhance management ultimately improving Fundus image thus represents valuable tool future precision medicine health management.
Язык: Английский
Процитировано
11
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Фев. 24, 2024
Abstract Myocardial infarction is defined as a sudden decrease or interruption in blood flow to the coronary arteries, causing ischemic necrosis of corresponding cardiomyocytes. It unclear whether systemic macrovascular alterations are associated with retinal microvascular changes. This study utilized optical coherence tomography angiography (OCTA) compare variations conjunctival vascular density and fundus vessel between patients myocardial (MI) healthy controls. recruited 16 (32 eyes) MI controls eyes). The superficial layer (SRL), deep (DRL) capillary plexus each eye were evaluated by OCTA. Parameters measured included temporal capillary, (MIR) (MAR) total MIR (TMI). region was hemisphere segmentation (SR, SL, IL, IR), annular partition (C1, C2, C3, C4, C5 C6), modified early treatment diabetic retinopathy (R, S, L, I) methods. In macular area, densities displayed notable variations. layers, TMI, MIR, MAR, well C1, C6 regions, significantly lower (p < 0.05 each). TMI), C2 regions contrast, higher than 0.001). layers conjunctiva differ OCTA effective detecting changes ocular microcirculation.
Язык: Английский
Процитировано
5
Life, Год журнала: 2024, Номер 14(4), С. 448 - 448
Опубликована: Март 28, 2024
Background: Retinal microvascular anomalies have been identified in patients with cardiovascular conditions such as arterial hypertension, diabetes mellitus, and carotid artery disease. We conducted a systematic review meta-analysis (PROSPERO registration number CRD42024506589) to explore the potential of retinal vasculature biomarker for diagnosis monitoring coronary disease (CAD) through optical coherence tomography (OCT) angiography (OCTA). Methods: systematically examined original articles Pubmed, Embase, Web Science databases from their inception up November 2023, comparing features between CAD control groups. Studies were included if they reported sample mean standard deviation or median range and/or interquartile (which computed into deviation). Review Manager 5.4 (The Cochrane Collaboration, 2020) software was used calculate pooled effect size weighted difference 95% confidence intervals (CI) by random-effects inverse variance method. Results: Eleven studies meeting inclusion criteria incorporated meta-analysis. The findings indicated significant decrease nerve fiber layer (WMD −3.11 [−6.06, −0.16]), subfoveal choroid −58.79 [−64.65, −52.93]), overall thickness −4.61 [−7.05, −2.17]) among compared controls (p < 0.05). Furthermore, vascular macular density notably lower patients, particularly superficial capillary plexus (foveal vessel WMD −2.19 [−3.02, −1.135], p 0.0001). Additionally, foveal avascular zone area statistically larger group 52.73 [8.79, 96.67], = 0.02). Heterogeneity (I2 > 50%) most except thickness, retina density. Conclusion: current suggests that vascularization could function noninvasive biomarker, providing additional insights beyond routine examinations assessing dysfunction arteries.
Язык: Английский
Процитировано
5
Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2023, Номер 17(11), С. 102882 - 102882
Опубликована: Окт. 23, 2023
Язык: Английский
Процитировано
10
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(3), С. 829 - 829
Опубликована: Янв. 31, 2024
Alterations in microvasculature represent some of the earliest pathological processes across a wide variety human diseases. In many organs, however, inaccessibility and difficulty directly imaging tissues prevent assessment microvascular changes, thereby significantly limiting their translation into improved patient care. The eye provides unique solution by allowing for non-invasive direct visualization quantification aspects microvasculature, including biomarkers structure, function, hemodynamics, metabolism. Optical coherence tomography angiography (OCTA) studies have specifically identified reduced capillary densities at level retina several diseases glaucoma. This narrative review examines published data related to OCTA-assessed major systemic cardiovascular disease. While loss capillaries is being established various ocular disease, pilot suggest that changes retinal especially within macula, may also reflect small vessel damage occurring other organs resulting from Current evidence suggests as potential indicators diseases, arterial hypertension, atherosclerotic congestive heart failure.
Язык: Английский
Процитировано
4
American Heart Journal Plus Cardiology Research and Practice, Год журнала: 2025, Номер 51, С. 100502 - 100502
Опубликована: Янв. 30, 2025
To compare retinal microvascular density among women with ischemia no obstructive coronary artery disease (INOCA) and without dysfunction (CMD). Cross-sectional study. Patients myocardial INOCA often have CMD, possibly indicating systemic vascular dysfunction. While microvasculature relates to many cardiovascular risk factors, its link CMD remains unknown. Women (N = 18) function testing were enrolled classified into non-CMD groups, defined as flow reserve (CFR) <2.5 in response adenosine. Participants underwent optical coherence tomography angiography for noninvasive imaging of the microvasculature. Vessel density, perfusion area, perimeter, circularity foveal avascular zone (FAZ). Non-parametric statistics used comparisons. Mean age was 54.7 (SD 12.5) years. The 11) 7) groups balanced respect age, BMI, diseases including diabetes, hypertension, hyperlipidemia, medications. Those had a lower vessel [20.9 (0.7) vs 21.6(0.8), p 0.006] inner [38.5 (1.6) 41.2 (0.8), compared those CMD. There differences FAZ or circularity. In this study INOCA, showed densities than Direct, non-invasive is feasible, affordable, may reflect patients. A larger study, men, needed confirm these findings.
Язык: Английский
Процитировано
0
Graefe s Archive for Clinical and Experimental Ophthalmology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 15, 2025
Язык: Английский
Процитировано
0
Eye, Год журнала: 2025, Номер unknown
Опубликована: Май 14, 2025
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2024, Номер unknown
Опубликована: Фев. 13, 2024
We conducted a systematic review and meta-analysis to assess the association between optical coherence tomography angiography (OCTA) parameters acute coronary syndrome (ACS). Two independent reviewers searched electronic databases (MEDLINE (Medical Literature Analysis Retrieval System Online), Scopus, Embase (Excerpta Medica Database), Cochrane Library, ClinicalTrials.gov, World Health Organization International Clinical Trials Registry Platform) from inception until April 2023. According inclusion criteria of this review, eligible were observational studies, randomized control trials, registry/database studies that included eyes adult ACS patients assessed OCTA within macula. The pooled standardized mean differences (SMD) diagnosed with healthy controls confidence interval (CI) 95% calculated using Hartung-Knapp-Sidik-Jonkman random-effects method. heterogeneity was by I2 Cochran Q random effects model applied. Seven in our (n = 898), which three 341). SMD superficial vascular plexus (SVP), deep (DVP), foveal avascular zone (FAZ) -0.46 (95% CI: -0.94 0.01, p 0.05, 0%, studies), -0.10 -3.20 3.00, 0.75, 67%, two 0.43 -1.22 2.09, 0.38, 92%, respectively. Our findings suggest there are no metrics individuals.
Язык: Английский
Процитировано
2