Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер unknown, С. 167806 - 167806

Опубликована: Март 1, 2025

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, necessitating innovative approaches for early detection and personalized interventions. Lipidomics, leveraging advanced mass spectrometry techniques, has become instrumental in deciphering lipid-mediated mechanisms CVDs. This review explores application lipidomics identifying biomarkers myocardial infarction, heart failure, stroke, calcific aortic valve stenosis (CAVS). examines technological advancements shotgun LC/MS, which provide unparalleled insights into lipid composition function. Key biomarkers, including ceramides lysophospholipids, have been linked to disease progression therapeutic outcomes. Integrating with genomic proteomic data reveals molecular underpinnings CVDs, enhancing risk prediction intervention strategies. positions as a transformative tool reshaping cardiovascular research clinical practice.

Язык: Английский