Geographic atrophy: understanding the relationship between structure and function DOI Creative Commons

Aihua Huang,

Zhichao Wu, Georg Ansari

и другие.

Asia-Pacific Journal of Ophthalmology, Год журнала: 2025, Номер unknown, С. 100207 - 100207

Опубликована: Май 1, 2025

This review explores the complex relationship between anatomical alterations and functional consequences in geographic atrophy (GA), advanced non-neovascular form of age-related macular degeneration. We examine natural history, progression patterns, structural biomarkers, assessments, structure-function correlations GA. Experts contributed specialized knowledge on GA pathophysiology, imaging assessment methods. synthesized an understanding changes (including fundus autofluorescence optical coherence tomography markers, novel biomarkers) outcomes (visual acuity, microperimetry, reading performance, patient-reported outcomes), drawing from authors' research expertise relevant literature. While is defined by visible areas outer retinal atrophy, often discordant. Visual acuity incompletely reflects impact GA, as it may remain preserved until foveal involvement occurs. Microperimetric assessments reveal deficits extending beyond atrophic borders, with varying degrees correlation metrics. Different patterns demonstrate distinct implications rates. Recent innovations visual function testing offer enhanced characterization disease progression. The measures underlying pathophysiological mechanisms has important for clinical trial endpoints patient management. Multimodal incorporating both parameters essential comprehensive evaluation management particularly therapeutic approaches emerge.

Язык: Английский

Longitudinal Analysis of Mesopic Microperimetry in a Phase II Trial Evaluating Minocycline for Geographic Atrophy DOI Creative Commons

Thilaka Arunachalam,

M. Roselle Abraham,

Christine M. Orndahl

и другие.

Ophthalmology Science, Год журнала: 2025, Номер unknown, С. 100783 - 100783

Опубликована: Апрель 1, 2025

To analyze mesopic microperimetry data from a recent phase II trial of minocycline for geographic atrophy (GA) possible efficacy on the change in visual function and, absence efficacy, to perform longitudinal analyses as natural history study. Phase II, prospective, single-arm, nonrandomized trial. After 9-month run-in phase, participants began oral 100 mg twice daily 3 years. Individuals with GA ≥1 eye. Participants underwent at baseline, month 3, and every 6 months thereafter, using custom T-shaped test pattern. Rates parameters were compared between 24-month treatment by linear spline regression. The mean macular responding sensitivity; perilesional extralesional number absolute relative scotomatous loci. Thirty study eyes 30 (mean age 74.1 years) follow-up 27.4 months). For 5 parameters, no significant difference rate phases was observed. 2 -0.74 decibels (dB)/year (standard error [SE] 0.85; P = 0.39) sensitivity, -0.30 dB/year (SE 0.72) 1.23 1.01; 0.22) -0.02 0.01; 0.31) transformed sensitivity. incidence ratios 1.17 0.11; 0.14) loci 0.73 0.004) results do not appear consistent clinically meaningful effect decline progression. This is previous corresponding structural data. findings demonstrate advantages disadvantages different parameters. optimal testing patterns represent trade-off greater sensitivity vs. risk floor/ceiling effects, regional averages providing useful compromise. may provide insights guide development end points clinical trials. Proprietary or commercial disclosure be found Footnotes Disclosures this article.

Язык: Английский

Процитировано

0

Geographic atrophy: understanding the relationship between structure and function DOI Creative Commons

Aihua Huang,

Zhichao Wu, Georg Ansari

и другие.

Asia-Pacific Journal of Ophthalmology, Год журнала: 2025, Номер unknown, С. 100207 - 100207

Опубликована: Май 1, 2025

This review explores the complex relationship between anatomical alterations and functional consequences in geographic atrophy (GA), advanced non-neovascular form of age-related macular degeneration. We examine natural history, progression patterns, structural biomarkers, assessments, structure-function correlations GA. Experts contributed specialized knowledge on GA pathophysiology, imaging assessment methods. synthesized an understanding changes (including fundus autofluorescence optical coherence tomography markers, novel biomarkers) outcomes (visual acuity, microperimetry, reading performance, patient-reported outcomes), drawing from authors' research expertise relevant literature. While is defined by visible areas outer retinal atrophy, often discordant. Visual acuity incompletely reflects impact GA, as it may remain preserved until foveal involvement occurs. Microperimetric assessments reveal deficits extending beyond atrophic borders, with varying degrees correlation metrics. Different patterns demonstrate distinct implications rates. Recent innovations visual function testing offer enhanced characterization disease progression. The measures underlying pathophysiological mechanisms has important for clinical trial endpoints patient management. Multimodal incorporating both parameters essential comprehensive evaluation management particularly therapeutic approaches emerge.

Язык: Английский

Процитировано

0