Longitudinal Analysis of Mesopic Microperimetry in a Phase II Trial Evaluating Minocycline for Geographic Atrophy
Ophthalmology Science,
Год журнала:
2025,
Номер
unknown, С. 100783 - 100783
Опубликована: Апрель 1, 2025
To
analyze
mesopic
microperimetry
data
from
a
recent
phase
II
trial
of
minocycline
for
geographic
atrophy
(GA)
possible
efficacy
on
the
change
in
visual
function
and,
absence
efficacy,
to
perform
longitudinal
analyses
as
natural
history
study.
Phase
II,
prospective,
single-arm,
nonrandomized
trial.
After
9-month
run-in
phase,
participants
began
oral
100
mg
twice
daily
3
years.
Individuals
with
GA
≥1
eye.
Participants
underwent
at
baseline,
month
3,
and
every
6
months
thereafter,
using
custom
T-shaped
test
pattern.
Rates
parameters
were
compared
between
24-month
treatment
by
linear
spline
regression.
The
mean
macular
responding
sensitivity;
perilesional
extralesional
number
absolute
relative
scotomatous
loci.
Thirty
study
eyes
30
(mean
age
74.1
years)
follow-up
27.4
months).
For
5
parameters,
no
significant
difference
rate
phases
was
observed.
2
-0.74
decibels
(dB)/year
(standard
error
[SE]
0.85;
P
=
0.39)
sensitivity,
-0.30
dB/year
(SE
0.72)
1.23
1.01;
0.22)
-0.02
0.01;
0.31)
transformed
sensitivity.
incidence
ratios
1.17
0.11;
0.14)
loci
0.73
0.004)
results
do
not
appear
consistent
clinically
meaningful
effect
decline
progression.
This
is
previous
corresponding
structural
data.
findings
demonstrate
advantages
disadvantages
different
parameters.
optimal
testing
patterns
represent
trade-off
greater
sensitivity
vs.
risk
floor/ceiling
effects,
regional
averages
providing
useful
compromise.
may
provide
insights
guide
development
end
points
clinical
trials.
Proprietary
or
commercial
disclosure
be
found
Footnotes
Disclosures
this
article.
Язык: Английский
Geographic atrophy: understanding the relationship between structure and function
Asia-Pacific Journal of Ophthalmology,
Год журнала:
2025,
Номер
unknown, С. 100207 - 100207
Опубликована: Май 1, 2025
This
review
explores
the
complex
relationship
between
anatomical
alterations
and
functional
consequences
in
geographic
atrophy
(GA),
advanced
non-neovascular
form
of
age-related
macular
degeneration.
We
examine
natural
history,
progression
patterns,
structural
biomarkers,
assessments,
structure-function
correlations
GA.
Experts
contributed
specialized
knowledge
on
GA
pathophysiology,
imaging
assessment
methods.
synthesized
an
understanding
changes
(including
fundus
autofluorescence
optical
coherence
tomography
markers,
novel
biomarkers)
outcomes
(visual
acuity,
microperimetry,
reading
performance,
patient-reported
outcomes),
drawing
from
authors'
research
expertise
relevant
literature.
While
is
defined
by
visible
areas
outer
retinal
atrophy,
often
discordant.
Visual
acuity
incompletely
reflects
impact
GA,
as
it
may
remain
preserved
until
foveal
involvement
occurs.
Microperimetric
assessments
reveal
deficits
extending
beyond
atrophic
borders,
with
varying
degrees
correlation
metrics.
Different
patterns
demonstrate
distinct
implications
rates.
Recent
innovations
visual
function
testing
offer
enhanced
characterization
disease
progression.
The
measures
underlying
pathophysiological
mechanisms
has
important
for
clinical
trial
endpoints
patient
management.
Multimodal
incorporating
both
parameters
essential
comprehensive
evaluation
management
particularly
therapeutic
approaches
emerge.
Язык: Английский