Association of endometriosis with Sjögren's syndrome: Genetic insights (Review)

International Journal of Molecular Medicine, Год журнала: 2024, Номер 53(2)

Опубликована: Янв. 3, 2024

Patients with a history of endometriosis have an increased risk developing various autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis and celiac disease. There is potential association between susceptibility for Sjögren's syndrome (SS). SS common chronic, inflammatory, systemic, autoimmune, multifactorial disease complex pathology, genetic, epigenetic environmental factors contributing to the development this condition. It occurs in 0.5‑1% population, characterized by presence ocular dryness, lymphocytic infiltrations contributes neurological, gastrointestinal, vascular dermatological manifestations. Endometriosis estrogen‑dependent, multifactorial, heterogeneous gynecological disease, affecting ≤10% reproductive‑age women. occurrence endometrial tissue outside uterine cavity, mainly pelvic associated pain, dysmenorrhea, deep dyspareunia either subfertility or infertility. still unclear whether appears secondary response endometriosis, it developed due any shared mechanisms these conditions. The aim present review was explore further biological basis only co‑occurrence disorders but not their at clinical basis, focusing on analysis partially genetic background SS, clarification possible similarities underlying pathogenetic relevant molecular pathways.

Язык: Английский

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Plasma extracellular vesicles promote follicular T helper cell expansion in primary Sjögren's syndrome

Clinical Immunology, Год журнала: 2025, Номер unknown, С. 110458 - 110458

Опубликована: Фев. 1, 2025

Язык: Английский

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Age-Related Oral and Para-Oral Tissue Disorders: The Evolving Therapeutic and Diagnostic Potential of Exosomes

Dentistry Journal, Год журнала: 2025, Номер 13(3), С. 106 - 106

Опубликована: Фев. 27, 2025

This review highlights the key molecular and cellular mechanisms contributing to aging, such as DNA damage, mitochondrial dysfunction, telomere shortening, protein defective autophagy. These biological are involved in various oral health conditions prevalent elderly, including periodontal disease, cancer, xerostomia, dental caries, temporomandibular joint disorders. Exosomes generated by mesenchymal stem cells possess substantial therapeutic potential. exosomes nanosized extracellular vesicles derived from essential intercellular communication tissue homeostasis. The exosome-based therapies proved superior traditional cell-based approaches, due lower immunogenicity, ease of storage, avoidance complications associated with cell transplantation. Furthermore, diagnostic potential non-invasive biomarkers for aging processes age-related diseases offers insights into disease diagnosis, staging, monitoring. Among challenges future perspectives translating exosome research preclinical studies clinical applications is need standardized procedures fully harness capabilities exosomes.

Язык: Английский

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Exosomes: Insights from Retinoblastoma and Other Eye Cancers

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(19), С. 7055 - 7055

Опубликована: Сен. 25, 2020

Exosomes, considered as cell debris or garbage bags, have been later characterized nanometer-sized extracellular double-membrane lipid bilayer bio-vesicles secreted by the fusion of vesicular bodies with plasma membrane. The constituents and rate exosomes formation differ in different pathophysiological conditions. Exosomes are also observed studied parts eye, like retina, cornea, aqueous, vitreous humor. Tear fluid consists that shown to regulate various cellular processes. role eye cancers, especially retinoblastoma (RB), is not well explored, although few studies point towards their presence. Retinoblastoma an intraocular tumor constitutes 3% cases cancer children. Diagnosis RB may require invasive procedures, which might lead spread disease other parts. Due this reason, better ways diagnosis being explored. Studies on tumors serum help designing diagnostic approaches for RB. In article, we reviewed a special emphasis We miRNAs expressed tumor, serum, lines analyzed targets these from proteins identified exosomes. hsa-miR-494 hsa-miR-9, upregulated downregulated, respectively RB, maximum number targets. Although oppositely regulated, they share same Overall review provides up-to-date progress area exosome research,

Язык: Английский

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MicroRNAs in shaping the resolution phase of inflammation

Seminars in Cell and Developmental Biology, Год журнала: 2021, Номер 124, С. 48 - 62

Опубликована: Апрель 29, 2021

Язык: Английский

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