Deleted Journal,
Год журнала:
2023,
Номер
unknown, С. 31 - 59
Опубликована: Апрель 10, 2023
In
this
survey,
we
explore
the
latest
methods
and
trends
in
constructing
mining
biological
networks.
We
delve
into
cutting-edge
techniques
such
as
weighted
gene
co-expression
network
analysis
(WGCNA),
step-level
differential
response
(SLDR),
Biomedical
Entity
Expansion,
Ranking
Explorations
(BEERE),
Weighted
In-Network
Node
Expansion
(WINNER),
In-Path
Edge
(WIPER)
from
Bioinformatics
community,
well
breakthroughs
graph
like
parallel
subgraph
systems,
temporal
algorithms,
deep
learning.
To
ensure
a
solid
foundation,
provide
an
introductory-level
overview
of
six
well-established
types
systems
biology.
addition,
offer
concise
accessible
strategies
for
construction,
including
networks
(GCNs),
regulatory
(GRNs),
literature-mined
biomedical
explain
interdisciplinary
domains,
catering
to
both
researchers
data
experts.
Our
goal
is
comprehensive
guide
that
doesn't
require
significant
time
investment.
believe
these
current
will
help
readers
become
familiar
with
topic
practical
applications
tools
real-world
studies.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 24, 2024
The
development
of
effective
therapy
for
eradicating
glioblastoma
stem
cells
remains
a
major
challenge
due
to
their
aggressive
growth,
chemoresistance
and
radioresistance
which
are
mainly
conferred
by
aldehyde
dehydrogenase
(ALDH)1A1.
latter
is
the
main
stemness
mediator
via
enhancing
signaling
pathways
Wnt/β-catenin,
phosphatidylinositol
3-kinase/AKT,
hypoxia.
Furthermore,
ALDH1A1
mediates
therapeutic
resistance
inactivating
drugs,
stimulating
expression
drug
efflux
transporters,
detoxifying
reactive
radical
species,
thereby
apoptosis
arresting.
Recent
reports
disclosed
potent
broad-spectrum
anticancer
activities
unique
nanocomplexes
diethyldithiocarbamate
(DE,
inhibitor)
with
ferrous
oxide
nanoparticles
(FeO
NPs)
inducing
lipid
peroxidation-dependent
non-apoptotic
(iron
accumulation-triggered
ferroptosis),
was
reported.
Accordingly,
anti-stemness
activity
(DE-FeO
investigated
against
human
mouse
glioma
(GSCs)
radioresistant
GSCs
(GSCs-RR).
DE-FeO
NPs
exhibited
strongest
growth
inhibition
effect
on
treated
(MGG18
JX39P),
(GS
PDGF-GSC)
(IC
50
≤
70
161
μg/mL,
respectively).
also
revealed
higher
inhibitory
impact
than
standard
chemotherapy
(temozolomide,
TMZ)
self-renewal,
cancer
repopulation,
chemoresistance,
potentials.
Besides,
surpassed
TMZ
regarding
relative
all
studied
genes,
as
well
p-AKT/AKT
ratio
in
MGG18,
GS
(MGG18-RR
GS-RR).
This
influence
primarily
attributed
ferroptosis
induction,
confirmed
significant
elevation
cellular
oxygen
species
peroxidation
depletion
glutathione
peroxidase
4.
recorded
optimal
Log
P
value
crossing
blood
brain
barrier.
vitro
novel
study
declared
potency
collapsing
GSCs-RR
improving
sensitivity
radiotherapy,
indicating
that
may
be
promising
remedy
GBM.
Glioma
animal
models
will
needed
in-depth
studies
its
safe
effectiveness.
Abstract
Repopulation
of
residual
tumor
cells
impedes
curative
radiotherapy,
yet
the
mechanism
is
not
fully
understood.
It
recently
appreciated
that
cancer
adopt
a
transient
persistence
to
survive
stress
chemo‐
or
targeted
therapy
and
facilitate
eventual
relapse.
Here,
it
shown
likewise
enter
“radiation‐tolerant
persister”
(RTP)
state
evade
radiation
pressure
in
vitro
vivo.
RTP
are
characterized
by
enlarged
cell
size
with
complex
karyotype,
activated
type
I
interferon
pathway
two
gene
patterns
represented
CST3
SNCG.
have
potential
regenerate
progenies
via
viral
budding‐like
division,
interferon‐mediated
antiviral
signaling
impaired
progeny
production.
Depleting
SNCG
does
attenuate
formation
cells,
but
can
suppress
budding
repopulation.
Interestingly,
produced
actively
lose
their
aberrant
chromosomal
fragments
gradually
recover
back
constitution
similar
unirradiated
parental
cells.
Collectively,
this
study
reveals
novel
repopulation,
i.e.,
populations
employ
reversible
radiation‐persistence
poly‐
de‐polyploidization
radiotherapy
repopulate
tumor,
providing
new
therapeutic
concept
improve
outcome
patients
receiving
radiotherapy.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 694 - 694
Опубликована: Янв. 15, 2025
Long
non-coding
RNAs
(lncRNAs)
play
a
pivotal
role
in
regulating
gene
expression
and
are
critically
involved
the
progression
of
malignant
brain
tumors,
including
glioblastoma,
medulloblastoma,
meningioma.
These
lncRNAs
interact
with
microRNAs
(miRNAs),
proteins,
DNA,
influencing
key
processes
such
as
cell
proliferation,
migration,
invasion.
This
review
highlights
multifaceted
impact
lncRNA
dysregulation
on
tumor
underscores
their
potential
therapeutic
targets
to
enhance
efficacy
chemotherapy,
radiotherapy,
immunotherapy.
The
insights
provided
offer
new
directions
for
advancing
basic
research
clinical
applications
tumors.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(15), С. 8774 - 8774
Опубликована: Авг. 7, 2022
The
biological
impact
of
ionizing
radiation
(IR)
on
humans
depends
not
only
the
physical
properties
and
absorbed
dose
but
also
unique
susceptibility
exposed
individual.
A
critical
target
IR
is
DNA,
DNA
damage
response
a
safeguard
mechanism
for
maintaining
genomic
integrity
in
to
induced
cellular
stress.
Unrepaired
lesions
lead
various
mutations,
contributing
adverse
health
effects.
Cellular
sensitivity
highly
correlated
with
ability
cells
repair
lesions,
particular
coding
sequences
genes
that
affect
process
others
contribute
preserving
integrity.
However,
accurate
profiling
molecular
events
underlying
individual
requires
techniques
sensitive
readouts.
Here
we
summarize
recent
studies
have
used
whole-genome
analysis
identified
radiosensitivity.
Whereas
microarray
RNA-seq
provide
snapshot
transcriptome,
RNA
interference
(RNAi)
CRISPR-Cas9
are
powerful
tools
enable
modulation
gene
expression
characterizing
function
specific
involved
radiosensitivity
or
radioresistance.
Notably,
has
altered
landscape
genome-editing
technology
its
increased
readiness,
precision,
sensitivity.
Identifying
regulators
would
help
tailor
regimens
enhance
efficacy
therapeutic
treatments
fast-track
prediction
clinical
outcomes.
It
occupational
protection
based
average
sensitivity,
as
well
formulation
countermeasures
harmful
effects
radiation.
Lab on a Chip,
Год журнала:
2023,
Номер
23(11), С. 2664 - 2682
Опубликована: Янв. 1, 2023
Treatment
of
human
brain
tumour
biopsies,
maintained
on-chip,
with
type
I
PRMT
inhibitors
leads
to
apoptosis
through
changes
in
gene
expression
and
RNA
processing,
mediated
by
cross-talk
II
PRMT.
Cells,
Год журнала:
2024,
Номер
13(23), С. 1995 - 1995
Опубликована: Дек. 3, 2024
The
gold
standard
assay
for
radiation
response
is
the
clonogenic
assay,
a
normalized
colony
formation
(CFA)
that
can
capture
broad
range
of
radiation-induced
cell
death
mechanisms.
Traditionally,
this
relies
on
two-dimensional
(2D)
culture
conditions
with
colonies
counted
by
fixing
and
staining
protocols.
While
some
groups
have
converted
these
to
three-dimensional
(3D)
conditions,
models
still
utilize
2D-like
media
compositions
containing
serum
are
incompatible
stem-like
such
as
brain
tumor
initiating
cells
(BTICs)
form
self-aggregating
spheroids
in
neural
stem
media.
BTICs
preferred
patient-derived
model
system
studying
glioblastoma
(GBM)
they
tend
better
retain
molecular
phenotypic
characteristics
original
tissue.
As
such,
it
important
preclinical
studies
should
be
adapted
BTIC
conditions.
In
study,
we
describe
series
experimental
approaches
performing
CFA
experiments
cultures.
Our
results
indicate
serum-free
assays
feasible
combination
drug
testing
may
facilitate
translatability
findings.
Cells,
Год журнала:
2023,
Номер
12(17), С. 2171 - 2171
Опубликована: Авг. 30, 2023
Treatment
for
the
deadly
brain
tumor
glioblastoma
(GBM)
has
been
improved
through
non-invasive
addition
of
alternating
electric
fields,
called
treating
fields
(TTFields).
Improving
both
progression-free
and
overall
survival,
TTFields
are
currently
approved
treatment
recurrent
GBMs
as
a
monotherapy
in
adjuvant
setting
alongside
TMZ
newly
diagnosed
GBMs.
These
known
to
inhibit
mitosis,
but
full
molecular
impact
remains
undetermined.
Therefore,
we
sought
understand
ability
disrupt
growth
patterns
induce
kinomic
landscape
shifts
TMZ-sensitive
-resistant
GBM
cells.
We
determined
that
significantly
decreased
Kinomic
profiling
predicted
kinases
were
induced
or
repressed
by
TTFields,
suggesting
possible
therapy-specific
vulnerabilities.
Serving
potential
pro-survival
mechanism
kinomics
increased
activity
platelet-derived
growth-factor
receptor
alpha
(PDGFRα).
demonstrated
PDGFR
inhibitor,
crenolanib,
further
reduced
cell
comparison
either
alone.
Collectively,
our
data
suggest
efficacy
vitro
identify
common
signaling
responses
populations,
which
may
support
more
personalized
medicine
approaches.
Cancers,
Год журнала:
2024,
Номер
16(15), С. 2638 - 2638
Опубликована: Июль 24, 2024
Glioblastoma
(GBM)
presents
a
significant
public
health
challenge
as
the
deadliest
and
most
common
malignant
brain
tumor
in
adults.
Despite
standard-of-care
treatment,
which
includes
surgery,
radiation,
chemotherapy,
mortality
rates
are
high,
underscoring
critical
need
for
advancing
GBM
therapy.
Over
past
two
decades,
numerous
clinical
trials
have
been
performed,
yet
only
small
fraction
demonstrated
benefit,
raising
concerns
about
predictability
of
current
preclinical
models.
Traditionally,
studies
utilize
treatment-naïve
tumors,
failing
to
model
scenario
where
patients
undergo
treatment
prior
recurrence.
Recurrent
generally
exhibits
distinct
molecular
alterations
influenced
by
selection
pressures.
In
this
review,
we
discuss
impact
treatment—surgery,
chemotherapy—on
GBM.
We
also
provide
summary
treatments
used
models,
advocating
their
integration
enhance
translation
novel
strategies
improve
therapeutic
outcomes
