Association between red cell distribution width—albumin ratio and all-cause mortality in intensive care unit patients with heart failure
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 20, 2025
Aim
The
association
between
red
cell
distribution
width—albumin
ratio
(RAR)
and
the
risk
of
all-cause
mortality
in
intensive
care
unit
(ICU)
patients
with
heart
failure
remains
uncertain.
This
study
aimed
to
investigate
this
association.
Methods
Clinical
data
from
MIMIC-Ⅳ
(version
2.2)
database
was
utilized
for
analysis
ICU
failure.
Patients
were
categorized
into
quartiles
(Q1–Q4)
based
on
RAR
levels.
Kaplan-Meier
survival
multivariate
adjusted
Cox
regression
models
employed
assess
levels
outcomes
within
1
year.
Subgroup
used
evaluate
prognostic
impact
across
diverse
populations.
Restricted
cubic
spline
curves
threshold
effect
quantify
dose-response
relationship
mortality.
time-concordance
index
curve
carried
out
explore
additional
value
over
existing
scoring
systems,
Serial
Organ
Failure
Assessment
(SOFA)
Acute
Physiology
Chronic
Health
Evaluation
Ⅱ
(APACHE
Ⅱ).
Results
encompassed
a
cohort
4,506
patients,
indicating
that
individuals
higher
exhibited
an
elevated
(
p
<
0.001).
Multivariate
subgroup
demonstrated
Q2
[hazard
(HR)
1.15,
95%CI
0.98–1.34],
Q3
(HR
1.65,
1.39–1.96)
Q4
2.16,
1.74–2.68)
had
increased
compared
Q1
trend
0.001),
consistently
observed
most
subgroups,
except
different
ages.
Subsequent
revealed
inclusion
significantly
improved
basis
SOFA
APACHE
Ⅱ,
concordance
0.636
0.658
SOFA,
0.682
0.695
0.001
both).
Conclusion
found
high
level
independently
associated
1-year
failure,
stronger
young
middle-aged
effect,
which
could
potentially
serve
as
early
warning
indicator
high-risk
Язык: Английский
Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 9035 - 9035
Опубликована: Авг. 20, 2024
Cell
deaths
maintain
the
normal
function
of
tissues
and
organs.
In
pathological
conditions,
abnormal
activation
or
disruption
cell
death
often
leads
to
pathophysiological
effects.
Diabetic
kidney
disease
(DKD),
a
significant
microvascular
complication
diabetes,
is
linked
high
mortality
morbidity
rates,
imposing
substantial
burden
on
global
healthcare
systems
economies.
Loss
detachment
podocytes
are
key
changes
in
progression
DKD.
This
review
explores
potential
mechanisms
apoptosis,
necrosis,
autophagy,
pyroptosis,
ferroptosis,
cuproptosis,
podoptosis
podocytes,
focusing
how
different
modes
contribute
It
recognizes
limitations
current
research
presents
latest
basic
clinical
studies
targeting
podocyte
pathways
Lastly,
it
focuses
future
treat
DKD,
with
intention
inspiring
further
development
therapeutic
strategies.
Язык: Английский
Regulatory-Associated Protein of mTOR-Mediated Signaling: A Nexus Between Tumorigenesis and Disease
Targets,
Год журнала:
2024,
Номер
2(4), С. 341 - 371
Опубликована: Ноя. 7, 2024
RAPTOR
(regulatory-associated
protein
of
mTOR)
is
a
pivotal
component
the
mammalian
target
rapamycin
complex
1
(mTORC1),
playing
central
role
in
regulating
cell
growth,
metabolism
and
stress
responses.
As
scaffold
protein,
recruits
key
substrates
such
as
eukaryotic
initiation
factor
4E-binding
protein-1
(4E-BP1)
ribosomal
S6
kinase
(S6K),
facilitating
their
phosphorylation
by
mTORC1,
which
turn
drives
synthesis,
lipid
cellular
proliferation.
Its
regulatory
function
becomes
especially
crucial
under
conditions
nutrient
deprivation
or
stress,
where
it
enhances
stability
mTORC1
complex,
allowing
cells
to
adapt
fluctuating
environmental
cues.
The
hyperactivation
largely
mediated
RAPTOR,
frequently
observed
various
cancers,
contributing
uncontrolled
proliferation
tumorigenesis.
Moreover,
RAPTOR’s
modulation
immune
responses
metabolic
pathways
extends
its
influence
beyond
oncogenesis,
impacting
inflammatory
diseases
disorders.
This
review
meticulously
elucidates
structure,
post-translational
modifications
well
indispensable
within
emphasizing
functions
adaptation,
response
disease
pathology
including
oncogenesis.
Furthermore,
explores
emergent
therapeutic
avenues
targeting
RAPTOR-mediated
signaling,
underscoring
potential
revolutionize
cancer
treatment
management
related
pathophysiological
conditions.
Язык: Английский
ACSS2 and metabolic diseases: from lipid metabolism to therapeutic target
Alaa El-Kurjieh,
Reem Al-Arab,
Qamar Abou Hachem
и другие.
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 25, 2025
Elevated
incidence
of
metabolic
disorders
has
been
reported
worldwide
in
the
recent
decade,
highlighting
need
for
developing
efficient
therapies.
These
diseases
result
from
a
complex
interplay
various
factors
that
contribute
to
disease
progression,
complications,
and
resistance
current
treatment
options.
Acetyl-CoA
Synthetase
Short
Chain
Family
Member
2
(ACSS2)
is
nucleo-cytosolic
enzyme
with
both
lipogenic
regulatory
roles.
Studies
on
ACSS2
have
shown
it
involved
pathways
commonly
dysregulated
disorders,
leading
fat
deposition
disrupted
cellular
signaling.
Although
multiple
studies
suggested
role
rewiring
during
tumorigenesis,
few
examined
its
involvement
pathophysiology
diseases.
Recent
evidence
indicates
may
pathogenesis
making
examination
great
interest
potentially
aiding
development
new
therapeutic
strategies.
The
objective
this
review
summarize
understanding
ACSS2's
potential
as
target.
Язык: Английский
Targeting lipid metabolic reprogramming to alleviate diabetic kidney disease: molecular insights and therapeutic strategies
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 25, 2025
Diabetic
kidney
disease
(DKD)
is
one
of
the
major
complications
diabetes,
and
its
pathological
progression
closely
associated
with
lipid
metabolic
reprogramming.
Under
diabetic
conditions,
renal
cells
undergo
significant
abnormalities,
including
increased
uptake,
impaired
fatty
acid
oxidation,
disrupted
cholesterol
efflux,
enhanced
catabolism,
as
adaptive
responses
to
stress.
These
changes
result
in
accumulation
lipids
such
free
acids,
diacylglycerol,
ceramides,
leading
lipotoxicity
that
triggers
inflammation
fibrosis.
Hypoxia
DKD
microenvironment
suppresses
oxidation
promotes
synthesis
through
HIF-1α
pathway,
while
chronic
exacerbates
disturbances
via
inflammatory
cytokines,
inflammasomes,
macrophage
polarization.
Targeting
metabolism
represents
a
promising
therapeutic
strategy
for
alleviating
DKD;
however,
further
clinical
translational
studies
are
warranted
validate
efficacy
safety
these
approaches.
Язык: Английский
A novel L-shaped ortho-quinone analog targeting adenosine A2b receptor to inhibit epithelial-mesenchymal transition in colorectal cancer cells
Medical Oncology,
Год журнала:
2025,
Номер
42(6)
Опубликована: Май 5, 2025
Язык: Английский
Molecular mechanisms of diabetic nephropathy: A narrative review
Cell Biology International,
Год журнала:
2024,
Номер
48(9), С. 1240 - 1253
Опубликована: Июнь 30, 2024
Abstract
Diabetic
nephropathy
(DN)
is
the
predominant
secondary
resulting
in
global
end‐stage
renal
disease.
It
attracting
significant
attention
both
domestic
and
international
research
due
to
its
widespread
occurrence,
fast
advancement,
limited
choices
for
prevention
treatment.
The
pathophysiology
of
this
condition
intricate
involves
multiple
molecular
cellular
pathways
at
various
levels.
This
article
provides
a
concise
overview
processes
involved
development
DN.
discusses
factors,
such
as
signaling
pathways,
cytokines,
inflammatory
responses,
oxidative
stress,
damage,
autophagy,
epigenetics.
aim
offer
clinicians
valuable
reference
DN's
diagnosis,
treatment,
intervention.
Язык: Английский
Proteome characterization of liver–kidney comorbidity after microbial sepsis
The FASEB Journal,
Год журнала:
2024,
Номер
38(7)
Опубликована: Апрель 6, 2024
Abstract
Sepsis
is
a
life‐threatening
condition
that
occurs
when
the
body
responds
to
an
infection
but
subsequently
triggers
widespread
inflammation
and
impaired
blood
flow.
These
pathologic
responses
can
rapidly
cause
multiple
organ
dysfunction
or
failure
either
one
by
simultaneously.
The
fundamental
common
mechanisms
involved
in
sepsis‐induced
remain
unclear.
Here,
employing
quantitative
global
phosphoproteomics,
we
examine
liver's
temporal
proteome
phosphoproteome
changes
after
moderate
sepsis
induced
cecum
ligation
puncture.
In
total,
4593
proteins
1186
phosphoproteins
according
3275
phosphosites
were
identified.
To
characterize
liver–kidney
comorbidity
sepsis,
developed
mathematical
model
performed
cross‐analyses
of
liver
kidney
data
obtained
from
same
set
mice.
Beyond
immune
response,
showed
commonly
disturbed
pathways
key
regulators
are
linked
energy
metabolism
consumption.
Our
provide
open
resources
understand
communication
between
as
they
work
fight
maintain
homeostasis.
Язык: Английский
Molecular Targets and Small Molecules Modulating Acetyl Coenzyme A in Physiology and Diseases
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
8(1), С. 36 - 46
Опубликована: Дек. 18, 2024
Acetyl
coenzyme
A
(acetyl-CoA),
a
pivotal
regulatory
metabolite,
is
product
of
numerous
catabolic
reactions
and
substrate
for
various
anabolic
responses.
Its
role
extends
to
crucial
physiological
processes,
such
as
glucose
homeostasis
free
fatty
acid
utilization.
Moreover,
acetyl-CoA
plays
significant
part
in
reshaping
the
metabolic
microenvironment
influencing
progression
several
diseases
conditions,
including
cancer,
insulin
resistance,
diabetes,
heart
failure,
fear,
neuropathic
pain.
This
Review
delves
into
both
pathological
shedding
light
on
key
players
its
formation
within
cytosol.
We
specifically
focus
impact
malonyl-CoA
decarboxylase
(MCD),
synthetase2
(ACSS2),
ATP-citrate
lyase
(ACLY)
metabolism,
homeostasis,
utilization,
post-translational
modification
cellular
processes.
Additionally,
we
present
implications
MCD,
ACSS2,
ACLY
clinical
manifestations.
also
explores
potential
limitations
targeting
using
small
molecules
different
settings.
Язык: Английский