SLAM family-mediated crosstalk between tumor and immune cells in the tumor microenvironment: a promising biomarker and a potential therapeutic target for immune checkpoint therapies

Clinical & Translational Oncology, Год журнала: 2024, Номер 27(3), С. 901 - 908

Опубликована: Авг. 30, 2024

Язык: Английский

Noise induces intercellular Ca²⁺signaling waves and the unfolded protein response in the hearing cochlea

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 8, 2024

Abstract Exposure to loud noise is a common cause of acquired hearing loss. Disruption subcellular calcium homeostasis and downstream stress pathways in the endoplasmic reticulum mitochondria, including unfolded protein response, have been implicated pathophysiology noise-induced However, studies on association between has limited due ability measure dynamics mature-hearing, noise-exposed mice. We used genetically encoded indicator mouse model which GcAMP expressed specifically hair cells or supporting under control Myo15Cre Sox2Cre, respectively. performed live imaging UPR gene expression analysis 8-week-old mice exposed levels that cochlear synaptopathy (98 db SPL) permanent loss (106 dB SPL). activation occurred immediately after exposure was dose-dependent, with pro-apoptotic pathway upregulated only 106 exposure. Spontaneous transients intercellular waves cells, are present neonatal cochleae, were quiescent mature-hearing but re-activated upon associated more persistent expansive ICS wave activity. These findings demonstrate strong dose-dependent exposure, activation, changes suggesting targeting these may be effective develop treatments for

Язык: Английский

Cochlear Implant Outcomes in Patients With TMTC2-Associated Sensorineural Hearing Loss and Auditory Neuropathy/Auditory Dys-Synchrony

Otology & Neurotology, Год журнала: 2024, Номер 45(6), С. e478 - e482

Опубликована: Май 21, 2024

To investigate the outcomes of cochlear implantation in patients with TMTC2 -associated sensorineural hearing loss and auditory neuropathy/auditory dys-synchrony.

Язык: Английский