Limitations and Applications of Rodent Models in Tauopathy and Synucleinopathy Research

Journal of Neurochemistry, Год журнала: 2025, Номер 169(3)

Опубликована: Март 1, 2025

Rodent models that accurately recapitulate key aspects of human disease have long been fundamental to the successful development clinical interventions. This is greatly underscored in neurodegenerative field, where preclinical testing anti-prion therapeutics against rodent-adapted prions resulted small molecules effective but not prions. These findings provided critical lessons for ongoing efforts develop treatments patients with diseases caused by misfolding and accumulation proteins tau α-synuclein, or tauopathies synucleinopathies, respectively. To avoid potential pitfalls previously identified prion this review focuses on rodent currently available study α-synuclein pathogenesis, emphasizing strengths limitations each particular goal better supporting research.

Язык: Английский

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Targeting CB2 receptor with a novel antagonist reverses cognitive decline, neurodegeneration and pyroptosis in a TAU-dependent frontotemporal dementia mouse model

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Baicalin-Geniposide glycosides inhibit PM2.5-induced brain damage in rats via the 5-LOX/LTB4 pathway

Molecular Immunology, Год журнала: 2024, Номер 177, С. 62 - 72

Опубликована: Дек. 21, 2024

Язык: Английский

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Tertiary lymphoid organs contribute to kidney allograft rejection

Nature Reviews Nephrology, Год журнала: 2024, Номер 20(9), С. 567 - 567

Опубликована: Июль 29, 2024

Язык: Английский

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