Genes,
Год журнала:
2024,
Номер
15(12), С. 1591 - 1591
Опубликована: Дек. 11, 2024
The
immune
repertoire
(IR)
is
a
term
that
defines
the
combined
unique
genetic
rearrangements
of
antigen
receptors
expressed
by
B
and
T
lymphocytes.
IR
determines
ability
system
to
identify
respond
foreign
antigens
while
preserving
tolerance
host
antigens.
When
disrupted,
development
autoimmune
diseases
can
occur
due
attack
self-antigens.
Recent
technical
advances
in
profiling
allowed
identification
common
patterns
shared
antigen-binding
sequences
diverse
array
diseases.
However,
there
no
current
literature
date
evaluates
findings
skin
inflammatory
conditions.
In
this
review,
we
provide
an
overview
past
research
various
dermatologic
Enriching
our
understanding
IRs
these
conditions
critical
for
pathophysiology
behind
disease
onset
progression.
Furthermore,
B-cell
T-cell
will
help
devise
therapeutic
treatments
hopes
restoring
preventing
Arthritis Research & Therapy,
Год журнала:
2025,
Номер
27(1)
Опубликована: Май 10, 2025
Chimeric
antigen
receptor
(CAR)
T-cell
therapy
targeting
B
cells
has
shown
promising
results,
including
drug-free
remission,
in
adult-onset
autoimmune
diseases.
Extending
this
therapeutic
approach
to
the
pediatric
population,
particularly
for
juvenile
diseases,
presents
an
exciting
opportunity.
However,
challenges
specific
juvenile-onset
conditions,
such
as
long-term
adverse
events,
heightened
disease
activity,
and
imperative
reduce
steroid
exposure,
must
be
considered.
While
strategy
appears
viable
these
severe
limited
data
available
population
absence
of
evidence
on
cases
with
a
high
genetic
component,
monogenic
lupus,
represent
significant
challenges.
Most
lupus
are
associated
innate
immune
defects,
involvement
anomalies
remains
poorly
understood.
In
review,
we
examine
potential
indications,
current
knowledge,
limitations
CAR-T
cell
extending
discussion
beyond
early-onset
lupus.
Rare Disease and Orphan Drugs Journal,
Год журнала:
2025,
Номер
4(2)
Опубликована: Май 28, 2025
Systemic
lupus
erythematosus
(SLE)
poses
significant
diagnostic
challenges.
First,
it
is
characterized
by
a
highly
variable
combination
of
autoantibodies
and
wide
range
possible
organ
involvement
symptoms.
Second,
no
single
laboratory
test
can
definitively
confirm
or
exclude
the
diagnosis.
Third,
due
to
low
incidence
SLE,
clinicians
must
carefully
balance
considering
SLE
as
potential
diagnosis
against
more
common
causes
similar
The
joint
European
League
Against
Rheumatism/American
College
Rheumatology
(EULAR/ACR)
classification
criteria
provide
helpful
framework
for
thinking
about
diagnosis,
although
they
are
not
intended
use.
Nevertheless,
several
elements
-
such
requirement
anti-nuclear
antibodies
(ANA)
positivity
an
entry
point
(similar
screening
test),
weighted
scoring
clinical
immunological
features,
attribution
findings
only
when
likely
alternative
explanation
exists
highlight
principles
that
also
useful
in
process.
Conceptionally,
diagnosing
be
seen
three-step
process:
(1)
possibility
SLE;
(2)
systematically
collecting
evidence
diagnosis;
(3)
making
decision
based
on
whether
accumulated
sufficiently
supports
refutes
This
review
follows
discussing
Current Opinion in Rheumatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 24, 2024
Purpose
of
review
This
provides
an
update
on
the
rapidly
growing
field
engineered
cellular
therapies
for
autoimmune
disorders,
primarily
focusing
clinical
experience
and
correlative
studies
with
chimeric
antigen
receptor
(CAR)
T-cells.
Recent
findings
To
date,
two
case
series
describing
treatment
CAR
T-cell
therapy
systemic
lupus
erythematosus
(SLE)
suggest
that
drug-free
remission
can
be
sustained
in
patients
previously
treatment-refractory
disease.
The
outcomes
these
are
similar,
despite
use
different
constructs
lymphodepletion
regimens.
Although
it
is
not
yet
clear
whether
described
have
truly
been
cured,
majority
remissions
remained
durable
up
to
last
follow-up
at
1–2
years
from
treatment.
Meanwhile,
mechanistic
providing
a
window
into
how
transient
B-cell
depletion
mediates
lasting
benefit.
With
encouraging
data
SLE,
T-cells
other
novel
B-cell-depleting
agents
(e.g.
bispecific
engagers)
now
being
evaluated
as
conditions,
goal
response.
Summary
reports
highlight
promising
strategy
conditions;
however,
there
still
limited
experience,
better
insight
this
therapeutic
approach
expected
emerge
rapidly.
Biophysics Reports,
Год журнала:
2024,
Номер
11(2), С. 129 - 129
Опубликована: Ноя. 19, 2024
In
this
study,
we
conducted
a
comprehensive
proteomic
analysis
of
B
cells
from
the
spleen,
mesenteric
lymph
nodes
(mLN),
and
peripheral
blood
mononuclear
(PBMC)
in
time-course
model
systemic
lupus
erythematosus
(SLE)
using
female
MRL/lpr
mice.
By
combining
fluorescence-activated
cell
sorting
(FACS)
4D-Data-Independent
Acquisition
(4D-DIA)
mass
spectrometry,
quantified
nearly
8000
proteins,
identifying
significant
temporal
tissue-specific
changes
during
SLE
progression.
PBMC-derived
exhibited
early
alterations
by
Week
9,
while
spleen-derived
showed
similar
12.
We
identified
key
regulatory
including
BAFF,
BAFFR,
NFKB2,
involved
survival
activation,
as
well
novel
markers
such
CD11c
CD117,
which
have
previously
been
associated
with
other
immune
cells.
The
study
highlights
dynamic
reprogramming
proteomes
across
different
tissues,
distinct
contributions
to
pathogenesis,
providing
valuable
insights
into
molecular
mechanisms
underlying
dysregulation
lupus.
These
findings
offer
potential
therapeutic
targets
biomarkers
for
SLE.
Genes,
Год журнала:
2024,
Номер
15(12), С. 1591 - 1591
Опубликована: Дек. 11, 2024
The
immune
repertoire
(IR)
is
a
term
that
defines
the
combined
unique
genetic
rearrangements
of
antigen
receptors
expressed
by
B
and
T
lymphocytes.
IR
determines
ability
system
to
identify
respond
foreign
antigens
while
preserving
tolerance
host
antigens.
When
disrupted,
development
autoimmune
diseases
can
occur
due
attack
self-antigens.
Recent
technical
advances
in
profiling
allowed
identification
common
patterns
shared
antigen-binding
sequences
diverse
array
diseases.
However,
there
no
current
literature
date
evaluates
findings
skin
inflammatory
conditions.
In
this
review,
we
provide
an
overview
past
research
various
dermatologic
Enriching
our
understanding
IRs
these
conditions
critical
for
pathophysiology
behind
disease
onset
progression.
Furthermore,
B-cell
T-cell
will
help
devise
therapeutic
treatments
hopes
restoring
preventing
