Antioxidant Natural Plant Constituents for Diabetic Wound Repair DOI Creative Commons
Lele Meng, Xueying Zhang, Li Sun

и другие.

MedComm – Biomaterials and Applications, Год журнала: 2025, Номер 4(2)

Опубликована: Июнь 1, 2025

ABSTRACT Diabetes mellitus is a prevalent metabolic disorder characterized by prolonged hyperglycemic state, which can result in complications affecting multiple organ systems. Among these complications, impaired wound healing diabetic patients poses significant challenge, leading to considerable suffering and economic burden. This issue has emerged as one of the major challenges global healthcare, where oxidative stress, bacterial infections chronic inflammation are critical contributing factors. Antioxidant compounds derived from natural plants increasingly being explored research due their beneficial biological properties. These botanical components effectively scavenge excessive reactive oxygen species mitigate cellular damage associated with stress. By controlling infections, inhibiting pro‐inflammatory cytokines, enhancing activity antioxidant enzymes, not only improve microenvironment but also directly promote proliferation migration fibroblasts keratinocytes, thereby facilitating tissue regeneration. paper examines modulation control impact on inflammatory responses, promotion repair, focus application specific plant healing, delivery systems, clinical applications, well future directions.

Язык: Английский

SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation DOI Creative Commons
Wěi Li,

Mengyang Kang,

Guofeng Zhang

и другие.

Inflammation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Sirtuin-6 (SIRT6) has a pivotal role in wide array of cellular biological functions and is linked to the progression various diseases. Previous findings have identified SIRT6 as protective modulator against numerous diabetic complications. However, whether exerts foot ulcer (DFU) remains unstudied. This work established rat model DFU evaluated possible mediating wound healing DFU. Marked reductions levels were observed samples from patients rats. Increasing expression tissues remarkably decreased area, accelerated epithelialisation, increased collagen deposition improved angiogenesis. Moreover, up-modulation relieved oxidative stress inflammation The increase cultured vascular endothelial cells restrained cell apoptosis, elicited by high glucose (HG). HG-impaired migration capacity angiogenesis was also recovered increasing expression. Mechanism research revealed that overexpression reinforced activation Nrf2 pathway rats HG-exposed cells. Pharmacological suppression reversed effect on HG-triggered dysfunction. this indicate positive related which contributes improvement study highlights previously unaddressed healing, providing novel insights into its functions. hold significant clinical value identifying promising therapeutic target for improving healing.

Язык: Английский

Процитировано

0
Neutrophil extracellular traps induce fibroblast ferroptosis via IRE1α/XBP1-mediated ER stress to impair diabetic wound healing DOI Creative Commons
Hongbo Zhao, Yanhong Liu

Free Radical Biology and Medicine, Год журнала: 2025, Номер 236, С. 17 - 27

Опубликована: Май 14, 2025

Язык: Английский

Процитировано

0
Antioxidant Natural Plant Constituents for Diabetic Wound Repair DOI Creative Commons
Lele Meng, Xueying Zhang, Li Sun

и другие.

MedComm – Biomaterials and Applications, Год журнала: 2025, Номер 4(2)

Опубликована: Июнь 1, 2025

ABSTRACT Diabetes mellitus is a prevalent metabolic disorder characterized by prolonged hyperglycemic state, which can result in complications affecting multiple organ systems. Among these complications, impaired wound healing diabetic patients poses significant challenge, leading to considerable suffering and economic burden. This issue has emerged as one of the major challenges global healthcare, where oxidative stress, bacterial infections chronic inflammation are critical contributing factors. Antioxidant compounds derived from natural plants increasingly being explored research due their beneficial biological properties. These botanical components effectively scavenge excessive reactive oxygen species mitigate cellular damage associated with stress. By controlling infections, inhibiting pro‐inflammatory cytokines, enhancing activity antioxidant enzymes, not only improve microenvironment but also directly promote proliferation migration fibroblasts keratinocytes, thereby facilitating tissue regeneration. paper examines modulation control impact on inflammatory responses, promotion repair, focus application specific plant healing, delivery systems, clinical applications, well future directions.

Язык: Английский

Процитировано

0