LncRNA H19: a novel player in the regulation of diabetic kidney disease

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Окт. 27, 2023

Diabetic kidney disease (DKD), one of the most severe complications diabetes mellitus (DM), has received considerable attention owing to its increasing prevalence and contribution chronic (CKD) end-stage (ESRD). However, use drugs targeting DKD remains limited. Recent data suggest that long non-coding RNAs (lncRNAs) play a vital role in development DKD. The lncRNA H19 is first imprinted gene, which expressed embryo down-regulated at birth, tumors been subject controversy, however, recent years, it disease. LncRNA engaged pathological progression DKD, including glomerulosclerosis tubulointerstitial fibrosis via induction inflammatory responses, apoptosis, ferroptosis, pyroptosis, autophagy, oxidative damage. In this review, we highlight research on molecular mechanism regulatory forms epigenetic, post-transcriptional, post-translational regulation, providing new predictive marker therapeutic target for management

Язык: Английский

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Identification of Plasma hsa_circ_0001230 and hsa_circ_0023879 as Potential Novel Biomarkers for Focal Segmental Glomerulosclerosis and circRNA-miRNA-mRNA Network Analysis

Kidney & Blood Pressure Research, Год журнала: 2024, Номер unknown, С. 1 - 1

Опубликована: Апрель 22, 2024

<b><i>Introduction:</i></b> Focal segmental glomerulosclerosis (FSGS) is a common glomerulopathy with an unclear mechanism. The demand for FSGS clinical diagnostic biomarkers has not yet been met. Circular RNA (circRNA) novel non-coding multiple functions, but its value remains unexplored. This study aimed to identify circRNAs that could aid in early diagnosis and investigate their mechanisms podocyte injury. <b><i>Methods:</i></b> signature of plasma was identified by circRNA microarray. existence confirmed quantitative real-time polymerase chain reaction (qRT-PCR), RNase R assay, DNA sequencing. Plasma levels were evaluated qRT-PCR. appraised the receiver operating characteristic curve. circRNA-miRNA-mRNA network built Cytoscape 7.3.2. Statistically significant differences calculated Mann-Whitney U test. <b><i>Results:</i></b> A total 493 (165 upregulated, 328 downregulated) differentially expressed patients (<i>n</i> = 3) normal controls 3). Eight candidate demonstrated be circular stable transcripts. Among them, hsa_circ_0001230 hsa_circ_0023879 significantly upregulated 29) compared 51). areas under curve 0.668 0.753, respectively, while two-circRNA panel 0.763. pull-down analysis revealed sponge hsa-miR-106a. Additionally, positively regulated hsa-miR-106a target genes phosphatase tensin homolog (PTEN) Bcl-2-like protein 11 (BCL2L11) podocytes. <b><i>Conclusion:</i></b> are blood FSGS. They may regulate apoptosis competitively binding

Язык: Английский

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The role of mitochondrial dysfunction in kidney injury and disease

Autoimmunity Reviews, Год журнала: 2024, Номер 23(6), С. 103576 - 103576

Опубликована: Июнь 1, 2024

Язык: Английский

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The Role of Glomerular Epithelial Injury in Kidney Function Decline in Patients With Diabetic Kidney Disease in the TRIDENT Cohort

Kidney International Reports, Год журнала: 2021, Номер 6(4), С. 1066 - 1080

Опубликована: Фев. 6, 2021

Although diabetic kidney disease (DKD) is responsible for more than half of all chronic and end-stage (ESKD), the association light (LM) electron microscopic (EM) structural changes with clinical parameters prognosis in DKD incompletely understood.This an interim analysis 62 patients diagnosed biopsy-confirmed from multicenter TRIDENT (Transformative Research Diabetic Nephropathy) study. Twelve LM 8 EM descriptors, representing glomeruli, tubulointerstitium, vasculature were analyzed their relationship measures renal function. Patients followed every 6 months.Multivariable linear regression revealed that estimated glomerular filtration rate (eGFR) upon enrollment correlated best interstitial fibrosis. On other hand, function decline (eGFR slope) most lesions including global glomerulosclerosis mesangiolysis. Unbiased clustering based on histopathologic data identified 3 subgroups. The first cluster, encompassing subjects mildest histologic lesions, had preserved second third clusters similar degrees dysfunction damage, but differed degree epithelial cell podocyte injury (podocytopathy subtype). Cox proportional hazard showed cluster 2 highest risk to reach ESKD (hazard ratio: 17.89; 95% confidence interval: 2.13-149.79). Glomerular hyperplasia fibrosis significant predictors multivariate model.The study highlights between identifies role decline.

Язык: Английский

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From inflammation to renal fibrosis: A one-way road in autoimmunity?

Autoimmunity Reviews, Год журнала: 2023, Номер 23(4), С. 103466 - 103466

Опубликована: Окт. 15, 2023

Язык: Английский

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