Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 6, 2025
Primary
liver
cancer
is
a
common
malignant
tumor
of
the
digestive
system,
with
hepatocellular
carcinoma
(HCC)
being
most
prevalent
type.
It
characterized
by
high
malignancy,
insidious
onset,
and
lack
specific
early
diagnostic
therapeutic
markers,
posing
serious
threat
to
human
health.
The
occurrence
development
HCC
are
closely
related
its
metabolic
processes.
Similar
other
tumors,
reprogramming
occurs
extensively
in
cells,
glucose
metabolism
particularly
prominent.
This
abnormal
activation
glycolysis
inhibition
oxidative
phosphorylation
gluconeogenesis,
among
changes.
Glucose
provides
intermediates
energy
for
meet
demands
rapid
growth,
proliferation,
metastasis.
Additionally,
various
enzymes
signaling
molecules
involved
play
irreplaceable
roles.
Therefore,
regulating
key
pathways
these
processes
considered
an
important
target
diagnosis
treatment
HCC.
paper
reviews
current
status
progress
HCC,
aiming
provide
new
insights
diagnosis,
detection,
comprehensive
strategies
involving
combined
intervention
clinical
settings.
Abstract
O‐linked‐β‐N‐acetylglucosamine
(O‐GlcNAcylation)
is
a
distinctive
posttranslational
protein
modification
involving
the
coordinated
action
of
O‐GlcNAc
transferase
and
O‐GlcNAcase,
primarily
targeting
serine
or
threonine
residues
in
various
proteins.
This
impacts
functionality,
influencing
stability,
protein–protein
interactions,
localization.
Its
interaction
with
other
modifications
such
as
phosphorylation
ubiquitination
becoming
increasingly
evident.
Dysregulation
O‐GlcNAcylation
associated
numerous
human
diseases,
including
diabetes,
nervous
system
degeneration,
cancers.
review
extensively
explores
regulatory
mechanisms
O‐GlcNAcylation,
its
effects
on
cellular
physiology,
role
pathogenesis
diseases.
It
examines
implications
aberrant
diabetes
tumorigenesis,
highlighting
novel
insights
into
potential
cardiovascular
The
also
discusses
interplay
impact
cell
growth
metabolism.
By
synthesizing
current
research,
this
elucidates
multifaceted
roles
providing
comprehensive
reference
for
future
studies.
underscores
cycle
developing
therapeutic
strategies
pathologies.
Metabolites,
Год журнала:
2024,
Номер
14(6), С. 325 - 325
Опубликована: Июнь 8, 2024
Epigenetic
and
metabolic
reprogramming
alterations
are
two
important
features
of
tumors,
their
reversible,
spatial,
temporal
regulation
is
a
distinctive
hallmark
carcinogenesis.
Epigenetics,
which
focuses
on
gene
regulatory
mechanisms
beyond
the
DNA
sequence,
new
entry
point
for
tumor
therapy.
Moreover,
drives
hepatocellular
carcinoma
(HCC)
initiation
progression,
highlighting
significance
metabolism
in
this
disease.
Exploring
inter-regulatory
relationship
between
epigenetic
modification
has
become
one
hot
directions
current
research.
As
viral
etiologies
have
given
way
to
dysfunction-associated
steatotic
liver
disease
(MASLD)-induced
HCC,
it
urgent
that
complex
molecular
pathways
linking
them
hepatocarcinogenesis
be
explored.
However,
how
aberrant
crosstalk
modifications
affects
MASLD-induced
HCC
lacks
comprehensive
understanding.
A
better
understanding
linkages
necessary
improve
treatment
strategies.
For
reason,
review
examines
interwoven
landscape
carcinogenesis
context
focusing
regulating
development
interactions
while
also
updating
advances
modification-based
therapeutic
drugs
HCC.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 6, 2025
Primary
liver
cancer
is
a
common
malignant
tumor
of
the
digestive
system,
with
hepatocellular
carcinoma
(HCC)
being
most
prevalent
type.
It
characterized
by
high
malignancy,
insidious
onset,
and
lack
specific
early
diagnostic
therapeutic
markers,
posing
serious
threat
to
human
health.
The
occurrence
development
HCC
are
closely
related
its
metabolic
processes.
Similar
other
tumors,
reprogramming
occurs
extensively
in
cells,
glucose
metabolism
particularly
prominent.
This
abnormal
activation
glycolysis
inhibition
oxidative
phosphorylation
gluconeogenesis,
among
changes.
Glucose
provides
intermediates
energy
for
meet
demands
rapid
growth,
proliferation,
metastasis.
Additionally,
various
enzymes
signaling
molecules
involved
play
irreplaceable
roles.
Therefore,
regulating
key
pathways
these
processes
considered
an
important
target
diagnosis
treatment
HCC.
paper
reviews
current
status
progress
HCC,
aiming
provide
new
insights
diagnosis,
detection,
comprehensive
strategies
involving
combined
intervention
clinical
settings.
