Randomised trial of same vs opposite arm co-administration of inactivated influenza and SARS-CoV-2 mRNA vaccines

JCI Insight, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

BACKGROUND. The immunogenicity of current influenza vaccines need improvement. Inactivated and COVID-19 mRNA can be co-administered but randomized controlled trial data is lacking on whether the two are more immunogenic if given in same or opposite arms. Murine studies suggest adjuvant when co-formulated delivered together.

Язык: Английский

Characteristics of humoral responses to the first coronavirus disease booster vaccine and breakthrough infection in central China: a multicentre, prospective, longitudinal cohort study

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 7, 2025

The long-term immunogenicity, adverse effects, influencing factors, and protection from booster vaccines remain unclear. Specifically, little is known regarding the humoral immunity breakthrough infections associated with COVID-19 immunization. Therefore, we evaluated reactogenicity, protective effects of first coronavirus disease vaccine 23 months before after implementation dynamic zero epidemic control measures among healthcare staff. We prospectively included 389 staff members in China negative pre-enrolment severe acute respiratory syndrome 2 test results. Neutralising serum antibodies were every two till post-booster vaccination. Breakthrough infection was recorded or confirmed by SARS-CoV-2 specific PCR testing via throat swabs participants measures. At 15-30 days vaccination, mean concentration 6.4 times above initial concentrations. Poorer antibody responses correlated male sex, longer duration, same-manufacturer vaccines, post-routine intervals >210 between primary vaccinations. Higher rates durations but not levels neutralising vaccination participants. Adverse reactions non-serious. These doses induced rapid, robust responses, maintained for only 6-7 months. Neutralizing weaker than those vaccine, predicting that may be very different other infectious pathogens.

Язык: Английский

Bivalent mRNA booster vaccination recalls cellular and antibody immunity against antigenically divergent SARS-CoV-2 spike antigens

npj Vaccines, Год журнала: 2025, Номер 10(1)

Опубликована: Апрель 18, 2025

Язык: Английский