Porphyromonas gingivalis and Human Cytomegalovirus Co-Infection: A Potential Link Between Periodontal Disease and Oral Cancer Development DOI Open Access
Rancés Blanco, Juan P. Muñoz

Cancers, Год журнала: 2025, Номер 17(9), С. 1525 - 1525

Опубликована: Апрель 30, 2025

Periodontal disease (PD) is an inflammatory condition that can contribute to the development of oral cancer. Chronic inflammation from PD lead release mediators and growth factors promote tumorigenesis. Porphyromonas gingivalis (P. gingivalis) one several pathogens implicated in its potential link However, other viral infections, such as human cytomegalovirus (HCMV), also chronic inflammation, creating a favorable environment for cancer development. Objectives: The present literature review tries investigate possible influence P. HCMV co-infection fostering periodontitis. Methods: A comprehensive search was conducted PubMed Google Scholar, focusing on relevance significance articles examine role periodontal Results: evidence suggests may act synergistically modulate host immunity, disrupt epithelial integrity, interfere with key cellular pathways. These interactions enhance tissue destruction foster microenvironment conducive malignant transformation. most these findings stem vitro models small-scale clinical studies, limiting generalizability current conclusions. Conclusions: Although proposed interaction between provides compelling framework understanding how microbial co-infections cancer, remains preliminary largely associative. To support mechanistic hypotheses, future studies should give top priority vivo models, bigger patient cohorts, longitudinal studies.

Язык: Английский

Developing a Vaccine Against Human Cytomegalovirus: Identifying and Targeting HCMV’s Immunological Achilles’ Heel DOI Creative Commons

Anastasia Lankina,

Marta Brezmes Raposo, Alexander Hargreaves

и другие.

Vaccines, Год журнала: 2025, Номер 13(5), С. 435 - 435

Опубликована: Апрель 22, 2025

Human cytomegalovirus (HCMV) is a critical pathogen in immunocompromised populations, such as organ transplant recipients well congenitally infected neonates with immature immune systems. Despite decades of research and the growing financial burden associated management HCMV, there no licensed vaccine to date. In this review, we aim outline complexity HCMV antigens it presents journey challenges developing an effective vaccine, further highlight recent analyses most successful candidate so far—gB/MF59.

Язык: Английский

Процитировано

0
Porphyromonas gingivalis and Human Cytomegalovirus Co-Infection: A Potential Link Between Periodontal Disease and Oral Cancer Development DOI Open Access
Rancés Blanco, Juan P. Muñoz

Cancers, Год журнала: 2025, Номер 17(9), С. 1525 - 1525

Опубликована: Апрель 30, 2025

Periodontal disease (PD) is an inflammatory condition that can contribute to the development of oral cancer. Chronic inflammation from PD lead release mediators and growth factors promote tumorigenesis. Porphyromonas gingivalis (P. gingivalis) one several pathogens implicated in its potential link However, other viral infections, such as human cytomegalovirus (HCMV), also chronic inflammation, creating a favorable environment for cancer development. Objectives: The present literature review tries investigate possible influence P. HCMV co-infection fostering periodontitis. Methods: A comprehensive search was conducted PubMed Google Scholar, focusing on relevance significance articles examine role periodontal Results: evidence suggests may act synergistically modulate host immunity, disrupt epithelial integrity, interfere with key cellular pathways. These interactions enhance tissue destruction foster microenvironment conducive malignant transformation. most these findings stem vitro models small-scale clinical studies, limiting generalizability current conclusions. Conclusions: Although proposed interaction between provides compelling framework understanding how microbial co-infections cancer, remains preliminary largely associative. To support mechanistic hypotheses, future studies should give top priority vivo models, bigger patient cohorts, longitudinal studies.

Язык: Английский

Процитировано

0