Journal of the Academy of Consultation-Liaison Psychiatry, Год журнала: 2022, Номер 64(1), С. 73 - 82
Опубликована: Сен. 27, 2022
Язык: Английский
Journal of Psychosomatic Research, Год журнала: 2020, Номер 141, С. 110350 - 110350
Опубликована: Дек. 25, 2020
Язык: Английский
Процитировано
76
BMC Nursing, Год журнала: 2025, Номер 24(1)
Опубликована: Фев. 7, 2025
This study carried out to examine the effects of nursing care given coronary intensive patients according their circadian rhythms on sleep quality, pain, anxiety, and delirium. was designed as a randomised controlled, clinical investigation. The population consisted treated in unit training research hospital between September 2022 February 2023. Total 44 participants were included. included followed up for 3 days unit. Data collected using "Patient Information Form, Sleep Quality Scale Coronary Intensive Care Patients (SQ-CC), Visual Analogue (VAS), Morningness-Eveningness Questionnaire (MEQ), Hospital Anxiety Depression (HADS), Delirium Screening Checklist (ICDSC)." In addition, melatonin cortisol measurements made, data taken with smartwatch. intermediate chronotype, delirium, ventilator support, or sedative drugs excluded. chronotypes determined, intervention group by rhythms. No made control group, routine continued accordance functioning. Frequency distribution, dependent independent sample t-test, Wilcoxon test, repeated measures analysis variance, Mann Whitney U, chi-square used evaluate data. has been registered ClinicalTrials.gov (Identifiers: NCT04934436). During statistical analysis, groups coded Group A B, ensuring blinding statistician. group's quality increased compared (post-test SQ-CC total scores: 22.41 ± 6.67 vs. 50.45 10.63, p < 0.001). Although no significant difference found result study, there decrease pain score (VAS pre-test: 1.55 2.15, post-test: 0.68 2.21, = 0.036). anxiety decreased significantly HADS-Anxiety 3.18 3.29 8.50 5.66, post-test delirium higher ICDSC 0.32 0.48 1.18 0.50, Melatonin both without statistically differences them (melatonin levels: > 0.05). Considering sound levels environment, first-night decibel mean than (first-night mean: 56.58 2.43 dB 54.51 2.41 dB, Finally, smartwatch show times (p 0.05), but had more deep sleep, while less sleep. Nursing rhythm increases reduces risk acute syndrome
Язык: Английский
Процитировано
2
Clinical Neurophysiology, Год журнала: 2025, Номер 171, С. 38 - 50
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
1
Frontiers in Neurology, Год журнала: 2020, Номер 11
Опубликована: Сен. 18, 2020
Delirium is a syndrome characterized by acute brain failure resulting in neurocognitive disturbances affecting attention, awareness, and cognition. It highly prevalent among critically ill patients associated with increased morbidity mortality. A core domain of delirium represented behavioural sleep-wake cycle probably related to circadian rhythm disruption. The relationship between sleep, intensive care unit (ICU)-acquired complex likely bidirectional. In this review, we explore the proposed pathophysiological mechanisms sleep disruption dysrhythmia as possible contributing factors transitioning ICU highlight some most relevant caveats for understanding these phenomena. Specifically, will (1) review physiological consequences poor quality efficiency; (2) how neural substrate underlying clock functions may be disrupted delirium; (3) discuss role sedative drugs contributors chrono-disruption; and, (4) describe association abnormal sleep-pathological wakefulness, dysrhythmia, critical illness. Opportunities improve readjust rhythmicity realign exist therapeutic targets both prevention treatment ICU. Further research required better define conditions understand physiologic develop effective strategies.
Язык: Английский
Процитировано
58
Critical Care, Год журнала: 2021, Номер 25(1)
Опубликована: Сен. 15, 2021
Abstract Delirium is a clinical syndrome occurring in heterogeneous patient populations. It affects 45–87% of critical care patients and often associated with adverse outcomes including acquired dementia, institutionalisation, death. Despite an exponential increase delirium research recent years, the pathophysiological mechanisms resulting presentation are still hypotheses. Efforts have been made to categorise spectrum into clinically meaningful subgroups (subphenotypes), using psychomotor subtypes such as hypoactive, hyperactive, mixed, for example, also inflammatory non-inflammatory delirium. remains, however, constellation symptoms from variety risk factors precipitants currently no successful targeted pharmacological treatment. Identifying specific biological subphenotypes will greatly improve understanding relationship between putative pathways thus factors, precipitants, natural history, mechanism. This facilitate factor mitigation, identification potential methods interventional studies, informed family counselling. Here, we review evidence date propose framework identify subphenotypes. Endotype may be done by clustering their mechanism, which treatments. In order achieve subphenotypes, following steps must taken: (1) robust records kept at level. (2) Global collaboration large, cohorts. (3) Patients clustered identification, validation, mapping subphenotype stability.
Язык: Английский
Процитировано
50
International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(16), С. 8302 - 8302
Опубликована: Авг. 5, 2021
Social distancing and the shortage of healthcare professionals during COVID-19 pandemic, impact population aging on system, as well rapid pace digital innovation are catalyzing development implementation new technologies services in psychiatry. Is this transformation a blessing or curse for psychiatry? To answer question, we conducted literature review covering broad range eHealth services, including telepsychiatry; computer-, internet-, app-based cognitive behavioral therapy; virtual reality; applied games; medicine system; omics; neuroimaging; machine learning; precision psychiatry; clinical decision support; electronic health records; physician charting; language translators; online mental resources patients. We found that provide effective, scalable, cost-efficient options treatment people with limited no access to care. This highlights innovative spearheading way more effective safer treatments. identified artificially intelligent tools relieve physicians from routine tasks, allowing them focus collaborative doctor–patient relationships. The traditional clinics into ones is outlined, challenges associated successful deployment digitalization psychiatry highlighted.
Язык: Английский
Процитировано
48
General Hospital Psychiatry, Год журнала: 2022, Номер 79, С. 60 - 75
Опубликована: Окт. 21, 2022
Язык: Английский
Процитировано
38
Springer eBooks, Год журнала: 2023, Номер unknown, С. 149 - 156
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
18
Clinical Interventions in Aging, Год журнала: 2023, Номер Volume 18, С. 559 - 570
Опубликована: Апрель 1, 2023
Postoperative delirium (POD) is a common complication in operative patients. Neuroinflammation has been reported to be potential mechanism associated with the development of POD. Identifying available inflammatory markers such as C-reactive protein (CRP) would aid clinicians early detection Previous studies have demonstrated that CRP may promising predictive marker for Thus, this study aimed explore association between and POD among those elderly colorectal cancer (CRC) patients.643 patients CRC were included study. levels measured before operation on postoperative day 1. The univariate multivariate regression analyses used identify risk factors POD.Of 643 CRC, 112 cases (17.4%) had showed older age, higher level 1, percentage smoking, diabetes mellitus, chronic obstructive pulmonary disease (COPD) than without Preoperative was not Univariate age (> 70 years), COPD, 1 48 mg/L) patients.Postoperative an independent indicator patients, suggesting role undergoing surgery.
Язык: Английский
Процитировано
16
Annals of Surgery, Год журнала: 2023, Номер unknown
Опубликована: Апрель 27, 2023
The aim was to determine preoperative gut microbiota metabolites that may be associated with postoperative delirium (POD) development in patients and further study rodents.POD occurs 9% 50% of older undergoing anesthesia/surgery but lacks effective treatments or prevention. High-throughput metabolomics using liquid chromatography tandem mass spectrometry has accelerated disease-related biomarkers discovery. We performed metabolomic studies humans identify potential metabolite linked POD examined mechanisms rodents.We a prospective observational cohort examine the changes were POD. Then microbiota-related recapitulated by perturbation rodents. assessed mice battery behavioral tests including novel objective test, Y-maze open-field buried food test. through which influenced chemogenetics.Indole-3-propionic acid (IPA) is belongs indole family. Baseline plasma levels IPA significantly inversely correlated onset 103 (17 cases) human individuals. This relationship validated preclinical mouse models for POD: reducing promoted POD-like behavior. More importantly, administration deterred Colonization germ-free mutant Clostridium sporogenes did not produce IPA-promoted Chemogenetic revealed protective effect mediated, part, peroxisome proliferator-activated receptor gamma coactivator 1-alpha hippocampal interneurons.Gut microbiota-derived an important molecule implicated pathogenesis POD, could potentially harnessed
Язык: Английский
Процитировано
14