Similar normalizing effect of HSP70 and YB-1 stress proteins on the brain transcription of a mouse model of Alzheimer’s disease
Abstract
Previously,
we
demonstrated
therapeutic
effects
of
intranasal
administration
human
HSP70
and
YB-1
proteins
in
various
models
AD
including
olfactory
bulbectomized
(OBX)
mice.
Herein,
investigated
the
effect
these
two
stress
on
transcription
hippocampus
cortex
OBX
In
spite
different
structure
both
frequently
caused
pronounced
normalizing
changes
same
genes.
Thus,
genes
that
normalized
their
expression
due
to
action
recHSP70
or
recYB-1
coincide
by
61%.
More
than
60%
common
target
exhibited
complete
restoration
a
pattern
control
sham-operated
Notably,
number
with
altered
after
was
twice
as
high
cortex.
brain
mice
application
led
normalization
many
related
pathogenesis
participated
metabolism
Aβ
tau
proteins.
Importantly,
also
include
loci
involved
ribosome
biogenesis,
well
responsible
for
neurotransmitter
transport,
cognition,
apoptosis,
mitochondria
functions
protection
from
oxidative
stress.
A
significant
positive
all
six
cell
types
studied
most
observed
astrocytes.
Besides
AD-related
genes,
several
implicated
development
major
depression
other
neurodegenerative
diseases.
Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Май 6, 2025
Язык: Английский