Cumulative exposure to childhood adversity and risk of adult psychosis: a dose–response meta-analysis DOI
Aidan Flinn,

Rebecca Hefferman-Clarke,

Sophie Parker

и другие.

Psychological Medicine, Год журнала: 2025, Номер 55

Опубликована: Янв. 1, 2025

Abstract Background Past meta-analyses have confirmed robust associations between childhood traumatic experiences and the risk of psychosis. However, dose–response relationship cumulative adversity exposure psychosis observed in some, but not all, previous studies this area has been specifically scrutinized or substantiated via recommended meta-analytic methods. This meta-analysis aimed to synthesize available evidence on effects trauma outcomes. Methods PsycINFO, PubMed, EMBASE, Web Science, CNKI, WANFANG were searched from inception July 2024 identify observational reporting odds ratios for outcomes across multiple levels exposure. Dose–response extracted eligible synthesized error meta-regression analyses. Results Twenty-one comprising 59,975 participants included meta-analysis. A significant nonlinear was number adversities future ( p nonlinearity = .021). The pooled ratio increased 1.76 (95% confidence interval [CI]: 1.39–2.22) 1 6.46 CI: 4.37–9.53) 5+ exposures compared no experience. Conclusions provides a risk, with patterns suggestive an accelerating, more pronounced, at higher These findings underscore importance considering as putative potentially causative factor psychotic experiences, well early prevention intervention efforts targeting reduce

Язык: Английский

Cumulative exposure to childhood adversity and risk of adult psychosis: a dose–response meta-analysis DOI
Aidan Flinn,

Rebecca Hefferman-Clarke,

Sophie Parker

и другие.

Psychological Medicine, Год журнала: 2025, Номер 55

Опубликована: Янв. 1, 2025

Abstract Background Past meta-analyses have confirmed robust associations between childhood traumatic experiences and the risk of psychosis. However, dose–response relationship cumulative adversity exposure psychosis observed in some, but not all, previous studies this area has been specifically scrutinized or substantiated via recommended meta-analytic methods. This meta-analysis aimed to synthesize available evidence on effects trauma outcomes. Methods PsycINFO, PubMed, EMBASE, Web Science, CNKI, WANFANG were searched from inception July 2024 identify observational reporting odds ratios for outcomes across multiple levels exposure. Dose–response extracted eligible synthesized error meta-regression analyses. Results Twenty-one comprising 59,975 participants included meta-analysis. A significant nonlinear was number adversities future ( p nonlinearity = .021). The pooled ratio increased 1.76 (95% confidence interval [CI]: 1.39–2.22) 1 6.46 CI: 4.37–9.53) 5+ exposures compared no experience. Conclusions provides a risk, with patterns suggestive an accelerating, more pronounced, at higher These findings underscore importance considering as putative potentially causative factor psychotic experiences, well early prevention intervention efforts targeting reduce

Язык: Английский

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