Antibiotics,
Год журнала:
2023,
Номер
12(11), С. 1584 - 1584
Опубликована: Ноя. 2, 2023
Antibiotic
resistance
patterns
of
the
major
human
periodontal
pathogen
Porphyromonas
gingivalis
were
assessed
over
a
20-year
period
in
United
States.
Subgingival
P.
was
cultured
pre-treatment
from
2193
severe
periodontitis
patients
during
three
time
periods:
1999-2000
(936
patients),
2009-2010
(685
and
2019-2020
(572
patients).
The
clinical
isolates
tested
for
vitro
to
4
mg/L
clindamycin
doxycycline,
8
amoxicillin,
16
metronidazole,
with
post
hoc
combination
data
metronidazole
plus
amoxicillin.
Clindamycin-resistant
significantly
more
prevalent
(9.1%
patients)
(9.3%;
15-fold
increase)
as
compared
(0.6%).
amoxicillin
also
increased
0.1%
1.3%
2.8%
(28-fold
2019-2020.
doxycycline
low
(≤0.5%
prevalence),
statistically
unchanged,
period.
These
findings
are
first
reveal
marked
increases
20
years
clindamycin-resistant
amoxicillin-resistant
States
patients.
Increased
antibiotic
other
periodontitis-associated
bacteria
threatens
efficacy
antimicrobial
chemotherapy.
Cells,
Год журнала:
2024,
Номер
13(4), С. 315 - 315
Опубликована: Фев. 8, 2024
This
mapping
review
highlights
the
need
for
a
new
paradigm
in
understanding
of
peri-implantitis
pathogenesis.
The
biofilm-mediated
inflammation
and
bone
dysregulation
(BIND)
hypothesis
is
proposed,
focusing
on
relationship
between
biofilm,
inflammation,
biology.
close
interactions
immune
cells
are
discussed,
with
multiple
stable
states
likely
existing
clinically
observable
definitions
peri-implant
health
peri-implantitis.
framework
presented
aims
to
explain
transition
from
disease
as
staged
incremental
process,
where
factors
contribute
distinct
steps
towards
tipping
point
manifested
clinically.
These
might
be
reached
different
ways
patients
may
constitute
highly
individualised
paths.
Notably,
affecting
underlying
biology
identified
pathogenesis
peri-implantitis,
highlighting
that
disruptions
host–microbe
homeostasis
at
implant–mucosa
interface
not
sole
factor.
An
improved
will
allow
intervention
levels
personalised
treatment
approach.
Further
research
areas
identified,
such
use
novel
biomarkers
detect
changes
macrophage
polarisation
activation
status,
turnover.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2020,
Номер
10
Опубликована: Дек. 11, 2020
Peri-implantitis
and
periodontitis
are
both
polymicrobial
diseases
induced
by
subgingival
plaque
accumulation,
with
some
differing
clinical
features.
Studies
on
the
microbial
gene
transcription
activity
of
peri-implantitis
microbiota
limited.
This
study
aimed
to
verify
hypothesis
that
disease-specific
lead
features,
using
an
integrated
metagenomic,
metatranscriptomic,
network
analysis.
Metagenomic
data
in
were
obtained
from
same
21
subjects
metatranscriptomic
12
a
database.
The
co-occurrence
based
metagenomic
analysis
had
more
diverse
species
taxa
correlations
than
Solobacterium
moorei
Prevotella
denticola
high
core
specific
network.
Moreover,
plasmin
receptor/glyceraldehyde-3-phosphate
dehydrogenase
genes
was
higher
peri-implantitis.
These
differences
may
increase
complexity
microbiome
distinguish
symptoms
two
diseases.
findings
should
help
exploring
novel
biomarker
assist
diagnosis
preventive
treatment
design
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(23), С. 15609 - 15609
Опубликована: Ноя. 24, 2022
The
implementation
of
adjunctive
antibiotics
has
been
recommended
for
the
therapy
peri-implantitis
(PI).
In
this
review,
antibiotic
resistance
patterns
in
PI
patients
were
assessed.
A
systematic
scoping
review
observational
studies
and
trials
was
established
conjunction
with
PRISMA
extension
reviews.
SCOPUS,
PubMed/MEDLINE,
EMBASE,
SCIELO,
Web
Science,
LILACS
databases
reviewed
along
gray
literature.
primary
electronic
examination
produced
139
investigations.
Finally,
four
met
selection
criteria.
These
evaluated
214
implants
168
patients.
Porphyromonas
gingivalis
Fusobacterium
nucleatum
mainly
presented
high
to
tetracycline,
metronidazole,
erythromycin
Similarly,
Aggregatibacter
actinomycetemcomitans
also
highly
resistant
clindamycin
doxycycline.
Other
microorganisms
such
as
Tannerella
forsythia,
Parvimonas
micra,
Prevotella
intermedia/nigrescens
significant
levels
other
including
amoxicillin,
azithromycin,
moxifloxacin.
However,
most
did
not
show
combination
amoxicillin
metronidazole.
Although
management
antimicrobials
is
controversial,
relevant
used
treat
PI,
usually
prescribed
dentistry,
observed.
Clinicians
should
consider
demonstrated
treatment
its
public
health
consequences.
Antibiotics,
Год журнала:
2023,
Номер
12(11), С. 1584 - 1584
Опубликована: Ноя. 2, 2023
Antibiotic
resistance
patterns
of
the
major
human
periodontal
pathogen
Porphyromonas
gingivalis
were
assessed
over
a
20-year
period
in
United
States.
Subgingival
P.
was
cultured
pre-treatment
from
2193
severe
periodontitis
patients
during
three
time
periods:
1999-2000
(936
patients),
2009-2010
(685
and
2019-2020
(572
patients).
The
clinical
isolates
tested
for
vitro
to
4
mg/L
clindamycin
doxycycline,
8
amoxicillin,
16
metronidazole,
with
post
hoc
combination
data
metronidazole
plus
amoxicillin.
Clindamycin-resistant
significantly
more
prevalent
(9.1%
patients)
(9.3%;
15-fold
increase)
as
compared
(0.6%).
amoxicillin
also
increased
0.1%
1.3%
2.8%
(28-fold
2019-2020.
doxycycline
low
(≤0.5%
prevalence),
statistically
unchanged,
period.
These
findings
are
first
reveal
marked
increases
20
years
clindamycin-resistant
amoxicillin-resistant
States
patients.
Increased
antibiotic
other
periodontitis-associated
bacteria
threatens
efficacy
antimicrobial
chemotherapy.
