Cell Transplantation, Год журнала: 2024, Номер 33
Опубликована: Янв. 1, 2024
Язык: Английский
Cell Transplantation, Год журнала: 2024, Номер 33
Опубликована: Янв. 1, 2024
Xenotransplantation holds great promise as a solution to address the critical shortage of organs, but it raises concerns regarding potential transmission porcine viruses recipients, leading infections and even zoonotic diseases. Data used in this review were mainly from literature Pubmed database. Keywords included xenotransplantation, infection, virus, epidemiology. The original articles reviews selected relevant review’s theme. We major viral concern their risk transmission, diagnosis, treatment, ways prevent infection. Then, we pivot comprehensive overview current status xenotransplantation. In addition, offer our own insights recommendations for propelling xenotransplantation forward, transitioning preclinical experiments phase clinical trials. Viral pose considerable safety within particularly with possibility emerging or currently unidentified viruses. Clinical trials serve crucial platform progress standards However, further studies dedicated efforts are required effectively translate findings into practical applications that can improve measures field.
Язык: Английский
Процитировано
5
Genes, Год журнала: 2025, Номер 16(2), С. 215 - 215
Опубликована: Фев. 12, 2025
Solid organ transplantation remains a life-saving treatment for patients worldwide. Unfortunately, the supply of donor organs cannot meet current need, making search alternative sources even more essential. Xenotransplantation using sophisticated genetic engineering techniques to delete and overexpress specific genes in animal has been investigated as possible option. However, use exogenous tissue presents another host obstacles, particularly regarding rejection. Given these limitations, interspecies blastocyst complementation combination with precise gene knockouts unique, promising pathway transplant shortage. In recent years, great advancements have made field, encouraging results producing donor-derived chimeric host. That said, one major barriers successful chimerism is mismatch developmental stages cells embryo. Another barrier speeds between embryos. This review outlines 19 studies which was used generate solid organs. particular, genesis liver, lung, kidney, pancreas, heart, thyroid, thymus parathyroids investigated. Of studies, 7 included an model. 7, completed human pig host, all others were rat-mouse chimeras. While very demonstrated, several challenges continue persist. chimerism, generation contribution, synchronized donor-host development, well ethical concerns human-animal chimeras remain important aspects that will need be addressed future research.
Язык: Английский
Процитировано
0
Cell Transplantation, Год журнала: 2025, Номер 34
Опубликована: Янв. 1, 2025
Recent advances in biomedical technologies have extended the boundaries of previously established regulatory guidelines pertaining to stem cell research. These constrained study human pluripotent cells (hPSCs) and their derivatives from use under various conditions, including introduction hPSCs into brains host animals because concerns humanizing animal species. Other creating human-animal chimeras potential contribution not only brain but also germline. Some forbid growing embryos ex vivo beyond stage primitive streak development regarding creation forms life vivo. At subcellular level, there are regulating transfer mitochondria within embryos. molecular genome editing prevent permanent genetic alterations germline cells. other issues related been reviewed, new research by International Society for Stem Cell Research (ISSCR) its membership. Because many recommended changes ISSCR impact being conducted members American Neural Therapy Repair (ASNTR), ASNTR a task force review relevant recommendations determine which adopt society The final presented this document.
Язык: Английский
Процитировано
0
Hepatic Medicine Evidence and Research, Год журнала: 2024, Номер Volume 16, С. 11 - 29
Опубликована: Фев. 1, 2024
Orthotopic liver transplantation (OLT) currently serves as the sole definitive treatment for thousands of patients suffering from end-stage disease; and existing supply donor livers OLT is drastically outpaced by increasing demand. To alleviate this significant gap in treatment, several experimental approaches have been devised with aim either offering interim support to waiting on transplant list or bioengineering complete infusing them fresh hepatic cells. Recently, interspecies blastocyst complementation has emerged a promising method generating organs utero over short timeframe. When coupled gene editing technology, it brought about potentially revolutionary transformation regenerative medicine. Blastocyst harbors notable potential human large animals, which could be used xenotransplantation humans, addressing scarcity OLT. Nevertheless, substantial ethical challenges still need overcome produce larger domestic animals like pigs. This review compiles current understanding outlines future possibilities humans.
Язык: Английский
Процитировано
3
Cell Transplantation, Год журнала: 2024, Номер 33
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Journal of Central Nervous System Disease, Год журнала: 2024, Номер 16
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
0
Cell Transplantation, Год журнала: 2024, Номер 33
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0