Hydrophilic Components as Key Active Ingredients in Adipose‐Derived Matrix Bioscaffolds for Inducing Fat Regeneration DOI Creative Commons

Xiaomu Ma,

Yue Qiang,

Qian Wang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(31)

Опубликована: Авг. 27, 2024

Decellularized adipose-derived matrix (DAM) has emerged as a promising biomaterial for soft tissue reconstruction. However, due to lack of research on its complex composition, the understanding key components in DAM remains limited, leading inconsistent adipogenic properties and challenges optimizing preparation methods purposefully. In this study, it is proposed first time that comprises two distinct components: hydrophilic (H-DAM) lipophilic (L-DAM), each with markedly different effects fat regeneration. It confirmed H-DAM component inducing regeneration enhanced cell-cell cell-scaffold interactions, primarily mediated by Hedgehog signaling pathway. contrast, L-DAM exhibits poor cell adhesion contains more antigenic components, higher immunoinflammatory response reduced adipogenesis. addition, found intracellular proteins, which are abundant H-DAM, can be retained beneficial their hydrophilicity, contrary conventional view they shall removed. Accordingly, purified bioscaffold unprecedented efficacy immunogenicity. This finding provides insights developing scaffolds promotes realization xenotransplantation.

Язык: Английский

Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration DOI Creative Commons
Hossein Rayat Pisheh, Mahsa Sani

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

2
The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration DOI Creative Commons
Luca Dalle Carbonare, Mattia Cominacini, Elisabetta Trabetti

и другие.

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 12, 2025

Mesenchymal stem cells (MSCs) play a crucial role in bone formation and remodeling. Intrinsic genetic factors extrinsic environmental cues regulate their differentiation into osteoblasts. Within the microenvironment, complex network of biochemical biomechanical signals orchestrates homeostasis regeneration. In addition, crosstalk among MSCs, immune cells, neighboring cells-mediated by extracellular vesicles non-coding RNAs (such as circular micro RNAs) -profoundly influences osteogenic Recent studies have explored specific signaling pathways that contribute to effective regeneration, highlighting potential manipulating microenvironment enhance MSC functionality. The integration advanced biomaterials, gene editing techniques, controlled delivery systems is paving way for more targeted efficient regenerative therapies. Furthermore, artificial intelligence could improve tissue engineering, optimize biomaterial design, enable personalized treatment strategies. This review explores latest advancements emphasizing intricate interplay molecules. By providing comprehensive overview these mechanisms clinical implications, we aim shed light on future research directions this rapidly evolving field.

Язык: Английский

Процитировано

0
Hydrophilic Components as Key Active Ingredients in Adipose‐Derived Matrix Bioscaffolds for Inducing Fat Regeneration DOI Creative Commons

Xiaomu Ma,

Yue Qiang,

Qian Wang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(31)

Опубликована: Авг. 27, 2024

Decellularized adipose-derived matrix (DAM) has emerged as a promising biomaterial for soft tissue reconstruction. However, due to lack of research on its complex composition, the understanding key components in DAM remains limited, leading inconsistent adipogenic properties and challenges optimizing preparation methods purposefully. In this study, it is proposed first time that comprises two distinct components: hydrophilic (H-DAM) lipophilic (L-DAM), each with markedly different effects fat regeneration. It confirmed H-DAM component inducing regeneration enhanced cell-cell cell-scaffold interactions, primarily mediated by Hedgehog signaling pathway. contrast, L-DAM exhibits poor cell adhesion contains more antigenic components, higher immunoinflammatory response reduced adipogenesis. addition, found intracellular proteins, which are abundant H-DAM, can be retained beneficial their hydrophilicity, contrary conventional view they shall removed. Accordingly, purified bioscaffold unprecedented efficacy immunogenicity. This finding provides insights developing scaffolds promotes realization xenotransplantation.

Язык: Английский

Процитировано

1