European Radiology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 30, 2024
With SARS-CoV-2 evolving, disease severity and presentation have changed due to changes in mechanisms of entry effector site as well effects vaccination- and/or infection-acquired immunity. We re-assessed fetal lung pathology pregnancies with uncomplicated infections during the late, omicron-dominated pandemic phase inform understanding pregnancy consultation.
Язык: Английский
American Journal of Obstetrics & Gynecology MFM, Год журнала: 2023, Номер 5(7), С. 100981 - 100981
Опубликована: Апрель 23, 2023
COVID-19 during pregnancy can have serious effects on outcomes. The placenta acts as an infection barrier to the fetus and may mediate adverse Increased frequency of maternal vascular malperfusion has been detected in placentas patients with compared controls, but little is known about how timing severity affect placental pathology.
Язык: Английский
Процитировано
22
The Journal of Immunology, Год журнала: 2022, Номер 209(8), С. 1465 - 1473
Опубликована: Окт. 15, 2022
Abstract Widespread SARS-CoV-2 infection among pregnant individuals has led to a generation of fetuses exposed in utero, but the long-term impact such exposure remains unknown. Although fetal is rare, children born mothers with may be at increased risk for adverse neurodevelopmental and cardiometabolic outcomes. Fetal programming effects are likely mediated least part by maternal immune activation. In this review, we discuss recent evidence regarding prenatal on maternal, placental, response, as well implications health offspring. Extrapolating from what known about activation other contexts (e.g., obesity, HIV, influenza), review potential morbidity Based available data suggesting risk, highlight importance establishing large cohorts monitor offspring SARS-CoV-2–positive sequelae.
Язык: Английский
Процитировано
23
The Lancet Regional Health - Europe, Год журнала: 2023, Номер 26, С. 100587 - 100587
Опубликована: Янв. 21, 2023
There are known complications for fetuses after infection with SARS-CoV-2 during pregnancy. However, previous studies of in pregnancy have largely been limited to histopathologic placentas and prenatal on the effects different variants scarce date. To examine placenta fetus, we investigated fetal extra-fetal structures using MRI.For this prospective case-control study, two obstetric centers consecutively referred pregnant women MRI confirmed infection. Thirty-eight examinations were included matched 1:1 38 control cases respect sex, field strength, gestational age (average deviation 1.76 ± 1.65, median 1.5 days). Where available, pathohistological examination vaccination status was analysis. In MRI, shape thickness placenta, possible lobulation, vascular lesions quantified. Fetuses scanned organ or brain abnormalities.Of infection, 20/38 (52.6%) infected pre-Omicron 18/38 (47.4%) Omicron. Prenatal MRIs performed an average 83 days (±42.9, 80) first positive PCR test. Both (P = .008) Omicron .016) groups showed abnormalities form a globular compared cases. addition, group significantly thickened (6.35, 95% CI .02-12.65, P .048), more frequent lobules .046), hemorrhages .002). Fetal growth restriction (FGR) observed 25% (n 5/20, .017) group.SARS-CoV-2 infections can lead placental based events, which be well visualized MRI. Pre-Omicron cause greater damage than sub-lineages regard.Vienna Science Technology Fund.
Язык: Английский
Процитировано
14
Modern Pathology, Год журнала: 2024, Номер 37(3), С. 100422 - 100422
Опубликована: Янв. 6, 2024
Язык: Английский
Процитировано
5
Placenta, Год журнала: 2023, Номер 135, С. 43 - 50
Опубликована: Март 15, 2023
Язык: Английский
Процитировано
11
Journal of Personalized Medicine, Год журнала: 2023, Номер 13(4), С. 699 - 699
Опубликована: Апрель 21, 2023
As the COVID-19 pandemic continues into its third year, there is accumulating evidence on consequences of maternal infection. Emerging data indicate increased obstetrics risks, including complications, preterm births, impaired intrauterine fetal growth, hypertensive disorders, stillbirth, gestational diabetes, and a risk developmental defects in neonates. Overall, controversial concerns still exist regarding potential for vertical transmission. Histopathological examination placenta can represent useful instrument investigation contribute significant information possible immunohistopathological mechanisms involved developing unfavorable perinatal outcomes. Based current evidence, SARS-CoV-2 infection affect placental tissue by inducing several specific changes. The level involvement considered one determining factors outcomes during pregnancy due to inflammation vascular injuries contributing complex cascade immunological biological events; however, available does not strong absolute correlation between infection, lesions, obstetric existing studies are limited, we further explore at three different levels, using histology, immunohistochemistry, molecular genetics understand epidemiological virological changes observed ongoing pandemic.
Язык: Английский
Процитировано
10
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2022, Номер 1869(1), С. 166582 - 166582
Опубликована: Окт. 20, 2022
Язык: Английский
Процитировано
15
Diseases, Год журнала: 2024, Номер 12(7), С. 142 - 142
Опубликована: Июль 2, 2024
Background: SARS-CoV-2 can damage human placentas, leading to pregnancy complications, such as preeclampsia and premature birth. This study investigates the histopathological changes found in COVID-19-affected placentas. Materials Methods: included 23 placentas from patients with active COVID-19 during delivery 22 samples without infection their medical history. The underwent examination for pathology, trophoblast necrosis, signs of vessel damage, or fetal vascular malperfusion. Results: Newborns research group have lower weights Apgar scores than healthy newborns. In group, calcifications collapsed intervillous space were more frequent, inflammation was severe group. At same time, placenta SARS-CoV-2-positive showed accelerated maturation. Trophoblast necrosis only expression CD68+ elevated cohort, suggesting that macrophages constituted a significant part inflammatory infiltrate. increase lymphocyte B markers associated placental infarctions, while high levels CD3+, specific cytotoxic T lymphocytes, correlated injury. Conclusions: is pathological placenta, including calcification, villous Those appear be driven by cells macrophages, whose increased reflects ongoing histiocytic intervillositis placenta.
Язык: Английский
Процитировано
3
BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)
Опубликована: Март 26, 2025
In recent years, severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection has been prevalent worldwide. Pregnant women belong to a special group, and it is very important for clinicians pay attention the impact of SARS-CoV-2 on pregnancy outcomes. However, there are limited studies outcomes during first trimester. To investigate effect in trimester Clinical information pregnant whose last menstrual period was between October 1, 2022, April 2023, who were registered Obstetrics Gynecology department Peking University International Hospital, analyzed. Among them, 498 with included study group; while total 654 no control group. Mann Whitney U test, χ2 Fisher's exact probability method, multivariate logistic regression used analyze A 30 cases group experienced loss before 28 weeks gestation, 468 delivered. 41 613 The rates two groups 6.02% 6.27%, respectively, statistically significant difference (P > 0.05). There 0.05) baseline data (delivery age, pre-pregnancy body mass index, gestational parity) groups. neonatal malformation, premature birth, rupture membranes, postpartum hemorrhage, cesarean section, small age infants, low birth weight macrosomia, asphyxia compared, incidence hypertension significantly higher than that = 0.012). this single center study, we found may increase risk hypertension, incidences other adverse such as did not compared without
Язык: Английский
Процитировано
0
American Journal of Obstetrics and Gynecology, Год журнала: 2025, Номер 232(4), С. S160 - S175.e7
Опубликована: Апрель 1, 2025
COVID-19 in pregnancy is associated with placental immune activation, inflammation, and vascular malperfusion, but its impact on syncytiotrophoblast biology function unclear. This study aimed to determine the effects of maternal syncytiotrophoblasts using single-nucleus transcriptional profiling compare stress responses preeclampsia. For characterization syncytiotrophoblasts, we used RNA sequencing platform, single-cell combinatorial indexing (sci-RNA-seq3), profile villi fetal membranes from unvaccinated patients symptomatic at birth (n = 4), gestational age-matched controls a case critical second trimester delivery term 1). Clustering nuclei differential gene expression analysis was performed Seurat. Gene ontology conducted Enrichr. High-confidence target identify key transcription factor nodes governing response SARS-CoV-2 infection. Bioinformatic approaches were further dataset published preeclampsia signatures. Tissue analysis, including immunofluorescence, validate data histology for an expanded cohort placentas: 6), asymptomatic 3), 5), severe features 7). The analyzed comprised 15 cell clusters 47,889 nuclei. We identified 3 representing fusing mature overlapping distinct COVID-19. analyses indicated that following alterations syncytiotrophoblasts: (1) endoplasmic reticulum activation signaling pathways, unfolded protein integrated response; (2) regulation by CCAAT/enhancer-binding beta (CEBPB), master lineage; (3) upregulation preeclampsia-associated genes. Using complementary methods, confirmed increased levels proteins (eg, BiP, G3BP1) (spliced XBP1 mRNA), CEBPB (phosphorylation) Increased cytotrophoblast proliferation (Ki-67) also detected COVID-19, consistent trophoblast injury. Markers demonstrated similarities phenotype Maternal lineage factor, CEBPB. Similarities between provide insights into their clinical association.
Язык: Английский
Процитировано
0