Life,
Год журнала:
2023,
Номер
13(4), С. 970 - 970
Опубликована: Апрель 8, 2023
Alzheimer’s
disease
(AD),
a
progressive
and
chronic
neurodegenerative
syndrome,
is
categorized
by
cognitive
memory
damage
caused
the
aggregations
of
abnormal
proteins,
specifically
including
Tau
proteins
β-amyloid
in
brain
tissue.
Moreover,
mitochondrial
dysfunctions
are
principal
causes
AD,
which
associated
with
mitophagy
impairment.
Investigations
exploring
pharmacological
therapies
alongside
AD
have
explicitly
concentrated
on
molecules
accomplished
preventing/abolishing
gatherings
abovementioned
mitochondria
damages.
Mitophagy
removal
dead
autophagy
process.
Damages
mitophagy,
manner
diversified
degeneracy
resulting
an
ongoing
aggregation
malfunctioning
mitochondria,
were
also
suggested
to
support
AD.
Recently,
plentiful
reports
link
between
defective
This
treaty
highlights
updated
outlines
modern
innovations
developments
machinery
brains.
therapeutic
nanotherapeutic
strategies
targeting
dysfunction
presented
this
review.
Based
significant
role
diminished
we
suggest
that
application
different
approaches
aimed
at
stimulating
would
be
beneficial
for
or
reducing
induced
Ageing Research Reviews,
Год журнала:
2024,
Номер
102, С. 102578 - 102578
Опубликована: Ноя. 13, 2024
Alzheimer's
Disease
(AD)
is
the
most
common
form
of
dementia
among
elderly
people.
This
disease
imposes
a
significant
burden
on
healthcare
system,
society,
and
economy
due
to
increasing
global
aging
population.
Current
trials
with
drugs
or
bioactive
compounds
aimed
at
reducing
cerebral
Amyloid
beta
(Aβ)
plaques
tau
protein
neurofibrillary
tangles,
which
are
two
main
hallmarks
this
devastating
neurodegenerative
disease,
have
not
provided
results
in
terms
their
neuropathological
outcomes
nor
met
expected
clinical
end-points.
Ageing,
genetic
environmental
risk
factors,
along
different
symptoms
suggest
that
AD
complex
heterogeneous
disorder
multiple
interconnected
pathological
pathways
rather
than
single
entity.
In
present
review,
we
highlight
discuss
various
non-canonical,
Aβ-independent
mechanisms,
like
gliosis,
unhealthy
dietary
intake,
lipid
sugar
signaling,
cerebrovascular
damage
contribute
onset
development
AD.
We
emphasize
challenging
traditional
"amyloid
cascade
hypothesis"
may
improve
our
understanding
age-related
syndrome
help
fight
progressive
cognitive
decline
Healthcare,
Год журнала:
2023,
Номер
11(6), С. 868 - 868
Опубликована: Март 16, 2023
Alzheimer’s
disease
(AD)
and
Disease-Related
Dementias
(ADRD)
are
chronic
illnesses
that
highly
prevalent
in
African
Americans
(AA).
AD
ADRD
caused
by
multiple
factors,
such
as
genetic
mutations,
modifiable
non-modifiable
risk
lifestyle.
Histopathological,
morphological,
cellular
studies
revealed
how
changes
implicated
ADRD,
including
synaptic
damage,
inflammatory
responses,
hormonal
imbalance,
mitochondrial
abnormalities,
neuronal
loss,
addition
to
the
accumulation
of
amyloid
beta
phosphorylated
tau
brain.
The
contributions
race,
ethnicity,
location
socioeconomic
status
all
have
a
significant
impact
on
care
support
services
available
dementia
patients.
Furthermore,
disparities
health
entangled
with
social,
economic,
environmental
variables
perpetuate
disadvantages
among
different
groups,
particularly
Americans.
As
such,
it
remains
important
understand
various
racial
ethnic
groups
perceive,
access,
experience
care.
Considering
mounting
data
shows
AA
may
be
more
susceptible
than
white
people,
demographic
transition
creates
hurdles
providing
adequate
from
family
caregivers.
there
is
growing
recognition
pose
stress
caregivers
compared
people.
In
this
review,
we
examine
current
literature
concerning
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Апрель 30, 2024
Aims
White
matter
damage
(WMD)
is
linked
to
both
cerebral
palsy
and
cognitive
deficits
in
infants
born
prematurely.
The
focus
of
this
study
was
examine
how
caffeine
influences
the
acetylation
proteins
within
neonatal
white
evaluate
its
effectiveness
treating
caused
by
hypoxia-ischemia.
Main
methods
We
employed
a
method
combining
affinity
enrichment
with
advanced
liquid
chromatography
mass
spectrometry
profile
from
rats
grouped
into
control
(Sham),
hypoxic-ischemic
(HI),
caffeine-treated
(Caffeine)
groups.
Key
findings
Our
included
1,999
sites
lysine
across
1,123
proteins,
quantifiable
changes
noted
1,342
689
proteins.
Analysis
these
patterns
identified
recurring
sequences
adjacent
sites,
notably
YKacN,
FkacN,
G
*
GkacS.
Investigation
biological
roles
through
Gene
Ontology
analysis
indicated
their
involvement
variety
cellular
processes,
predominantly
mitochondrial
locations.
Further
that
tau
(Mapt),
protein
associated
microtubules,
elevated
HI
condition;
however,
treatment
appeared
mitigate
over-modification,
thus
potentially
aiding
reducing
oxidative
stress,
inflammation
nervous
system,
improving
health.
Caffeine
inhibited
acetylated
Mapt
sirtuin
2
(SITR2),
promoted
nuclear
translocation,
improved
dysfunction,
which
subsequently
weakened
SIRT2
inhibitor,
AK-7.
Significance
Caffeine-induced
may
play
key
role
dysfunction
inhibiting
stress
neuroinflammation.
Life,
Год журнала:
2023,
Номер
13(4), С. 970 - 970
Опубликована: Апрель 8, 2023
Alzheimer’s
disease
(AD),
a
progressive
and
chronic
neurodegenerative
syndrome,
is
categorized
by
cognitive
memory
damage
caused
the
aggregations
of
abnormal
proteins,
specifically
including
Tau
proteins
β-amyloid
in
brain
tissue.
Moreover,
mitochondrial
dysfunctions
are
principal
causes
AD,
which
associated
with
mitophagy
impairment.
Investigations
exploring
pharmacological
therapies
alongside
AD
have
explicitly
concentrated
on
molecules
accomplished
preventing/abolishing
gatherings
abovementioned
mitochondria
damages.
Mitophagy
removal
dead
autophagy
process.
Damages
mitophagy,
manner
diversified
degeneracy
resulting
an
ongoing
aggregation
malfunctioning
mitochondria,
were
also
suggested
to
support
AD.
Recently,
plentiful
reports
link
between
defective
This
treaty
highlights
updated
outlines
modern
innovations
developments
machinery
brains.
therapeutic
nanotherapeutic
strategies
targeting
dysfunction
presented
this
review.
Based
significant
role
diminished
we
suggest
that
application
different
approaches
aimed
at
stimulating
would
be
beneficial
for
or
reducing
induced
