MicroRNAs in Hepatocellular Carcinoma Pathogenesis: Insights into Mechanisms and Therapeutic Opportunities
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9393 - 9393
Опубликована: Авг. 29, 2024
Hepatocellular
carcinoma
(HCC)
presents
a
significant
global
health
burden,
with
alarming
statistics
revealing
its
rising
incidence
and
high
mortality
rates.
Despite
advances
in
medical
care,
HCC
treatment
remains
challenging
due
to
late-stage
diagnosis,
limited
effective
therapeutic
options,
tumor
heterogeneity,
drug
resistance.
MicroRNAs
(miRNAs)
have
attracted
substantial
attention
as
key
regulators
of
pathogenesis.
These
small
non-coding
RNA
molecules
play
pivotal
roles
modulating
gene
expression,
implicated
various
cellular
processes
relevant
cancer
development.
Understanding
the
intricate
network
miRNA-mediated
molecular
pathways
is
essential
for
unraveling
complex
mechanisms
underlying
hepatocarcinogenesis
developing
novel
approaches.
This
manuscript
aims
provide
comprehensive
review
recent
experimental
clinical
discoveries
regarding
role
miRNAs
influencing
hallmarks
HCC,
well
their
promising
utility
potential
targets.
Язык: Английский
Genetic Alchemy unveiled: MicroRNA-mediated gene therapy as the Artisan craft in the battlefront against hepatocellular carcinoma—a comprehensive chronicle of strategies and innovations
Frontiers in Genetics,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 10, 2024
Investigating
therapeutic
miRNAs
is
a
rewarding
endeavour
for
pharmaceutical
companies.
Since
its
discovery
in
1993,
our
understanding
of
miRNA
biology
has
advanced
significantly.
Numerous
studies
have
emphasised
the
disruption
expression
various
diseases,
making
them
appealing
candidates
innovative
approaches.
Hepatocellular
carcinoma
(HCC)
significant
malignancy
that
poses
severe
threat
to
human
health,
accounting
approximately
70%–85%
all
malignant
tumours.
Currently,
efficacy
several
HCC
therapies
limited.
Alterations
biomacromolecules
during
progression
and
their
underlying
mechanisms
provide
basis
investigation
novel
effective
MicroRNAs,
also
known
as
miRNAs,
been
identified
last
20
years
significantly
impact
gene
protein
translation.
This
atypical
pattern
strongly
associated
with
onset
malignancies.
Gene
therapy,
form
biological
prominent
research
area.
Therefore,
used
tumour
therapy.
review
examines
action
explores
correlation
between
HCC,
investigates
use
Язык: Английский
The Role of the MiR-181 Family in Hepatocellular Carcinoma
Cells,
Год журнала:
2024,
Номер
13(15), С. 1289 - 1289
Опубликована: Июль 31, 2024
Hepatocellular
carcinoma
(HCC)
is
the
fourth-leading
cause
of
cancer-related
death
worldwide.
Due
to
high
mortality
rate
in
HCC
patients,
discovering
and
developing
novel
systemic
treatment
options
for
a
vital
unmet
medical
need.
Among
numerous
molecular
alterations
HCCs,
microRNAs
(miRNAs)
have
been
increasingly
recognised
play
critical
roles
hepatocarcinogenesis.
We
others
recently
revealed
that
members
microRNA-181
(miR-181)
family
were
up-regulated
some,
though
not
all,
human
cirrhotic
tissues—this
up-regulation
induced
epithelial–mesenchymal
transition
(EMT)
hepatocytes
tumour
cells,
promoting
progression.
MiR-181s
crucial
governing
fate
function
various
such
as
endothelial
immune
cells.
Previous
reviews
extensively
covered
these
aspects
detail.
This
review
aims
give
some
insights
into
miR-181s,
their
targets
modulating
signal
transduction
pathways,
factors
regulating
miR-181
expression
function,
HCC.
Язык: Английский
MicroRNAs in Hepatocellular Carcinoma: Insights into Regulatory Mechanisms, Clinical Significance, and Therapeutic Potential
Cancer Management and Research,
Год журнала:
2024,
Номер
Volume 16, С. 1491 - 1507
Опубликована: Окт. 1, 2024
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
common
malignant
tumors.
Tumor
immune
microenvironment
(TIME),
angiogenesis,
epithelial-mesenchymal
transformation
(EMT),
invasion,
metastasis,
metabolism,
and
drug
resistance
are
main
factors
affecting
development
treatment
MiRNAs
play
crucial
roles
in
almost
all
major
cellular
biological
processes.
Studies
have
been
carried
out
on
miRNAs
as
biomarkers
therapeutic
targets.
Their
dysregulation
contributes
to
progression
prognosis
HCC.
This
review
aims
explore
molecular
cascades
corresponding
phenotypic
changes
caused
by
aberrant
miRNA
expression
their
regulatory
mechanisms,
summarize
analyze
novel
from
somatic
fluids
(plasma/serum/urine),
highlight
latent
capacity
Язык: Английский