Construction, validation, and visualization of a web-based nomogram to predict survival in male breast cancer patients with second primary prostate cancer DOI Open Access

Runsen Du,

Fangjian Shang, Xin Chen

и другие.

Gland Surgery, Год журнала: 2024, Номер 13(11), С. 2023 - 2042

Опубликована: Ноя. 1, 2024

The advancement of early detection and treatment has brought about a significant concern for male breast cancer (MBC) survivors-the emergence second primary malignancy (SPM) poses grave threat to their lives. Among them, prostate (spPCa) holds particular significance. This study aimed investigate the impact spPCa on prognosis MBC patients. We performed retrospective analysis using information from Surveillance, Epidemiology, End Results (SEER) database individuals diagnosed with who also experienced an SPM between 2000 2020. Propensity score matching (PSM) was employed balance baseline characteristics those non-prostate (non-PCa). participant survival assessed Kaplan-Meier method. Furthermore, two nomograms were developed, based univariate multifactor Cox regression analyses, predict overall (OS) cancer-specific (CSS). capacity evaluated concordance index (C-index), calibration curve, receiver operating characteristic (ROC) analysis, decision curve (DCA). Additionally, risk stratification system devised, taking into account cumulative each patient in nomogram. enrolled total 885 patients SPM, which 265 (29.9%) spPCa. Through PSM, 257 pairs eligible participants selected. Survival revealed that (PCa) as have longer OS CSS compared other types SPM. randomly divided training set validation ratio 7:3. proportional hazards model utilized assess factors associated outcomes. Two developed forecast 3-, 5-, 8-, 10-year had exhibited excellent performance terms C-index, ROC curves, plots, DCA demonstrating exceptional clinical discriminative ability predictive utility. In predicated nomogram, deemed high-risk diminished CSS. we created user-friendly web applications enhance accessibility nomogram practices, can be accessed at https://mbcpre.shinyapps.io/DynNomapp_OS/ https://mbcpre.shinyapps.io/DynNomapp_CSS/ exhibit more favorable than SPMs. constructed could accurately Patients whose are stratified should gain additional attention. Our may aid clinicians personalizing strategies supporting decisions.

Язык: Английский

Breast cancer mortality in Brazilian men: an age-period-cohort study DOI
Lucas Casagrande Passoni Lopes

Mastology, Год журнала: 2025, Номер 34

Опубликована: Апрель 4, 2025

Introduction: Male breast cancer is a rare malignancy whose health impacts remain unknown, notably in countries like Brazil. The purpose of this article was to evaluate mortality Brazilian men by an age-period-cohort study. Methods: This ecological study evaluates the due using model. Data were sourced from public, open-access database DATASUS, available at https://datasus.saude.gov.br, covering period 1996 2021. Demographic data represent total population males, while clinical focus on patients cause death coded as 175 (ICD-9) or C50 (ICD-10). effects analyzed following classic model and its adaptations. analysis performed R 4.4.0. Alpha® software. Results: It noted increasing trend with aging, peaking over 80 years old. From 2009, no statistically significant changes observed hazard ratio (HR). However, 2010 onward, increase HR found, reaching peak 2020–2021 (HR 2.79634; 95%CI 2.37121–3.29770). A 34 birth cohorts (1919–2011) analyzed. Cohorts 1919–1964 1981–2011 did not show results, those 1966–1979 exhibited decreasing HR, lowest seen 1979 cohort 0.91323; 0.83545–0.99825). Conclusions: identifies growing male Brazil, particularly after 2010, variations across cohorts.

Язык: Английский

Процитировано

0
Reply to Comment to: A Three-Dimensional Approach to Male Chest Enhancement: A Surgical Algorithm Based on 300 Cases DOI
Damiano Tambasco,

Federica Tomaselli,

Roberta Albanese

и другие.

Aesthetic Plastic Surgery, Год журнала: 2024, Номер unknown

Опубликована: Окт. 9, 2024

Язык: Английский

Процитировано

1
An in silico approach uncovering the competency of oncolytic human adenovirus 52 for targeted breast cancer virotherapy DOI Creative Commons
Muhammad Naveed,

Zainab Batool,

Tariq Aziz

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 2, 2024

Breast cancer remains a major health threat throughout the world specifically in women above 30 years of age however, it is rarely known to affect men as well. It characterized by abnormal division cells breast tissue resulting development malignancies. Various risk factors contributing include age, family history, genetic mutations (chiefly BRCA1 and BRCA2 genes) along with hormonal imbalances (oestrogen, progesterone, HER2). Early detection which can be obtained through frequent rounds self-examination, mammographic scanning, clinical assessment plays crucial role prevention disease. In addition, appropriate diagnosis assists better therapeutic responses. This study highlights considerable risks associated conventional treatment procedures arise increased demand advanced, secure, risk-free alternatives. Oncolytic viruses are potentially apparent for aim improving therapeutics reduced side effects. These act fundamental agent themselves that selectively target kill malignant without harm healthy tissues. The key objective research provide evidence Human Adenovirus 52 potent oncolytic virus highlight its capacity eliminate precision while causing least amount Validating in-silico method entails evaluating dependability computational modelling contrasting predictions findings from experiments rank secondary objective. workflow this utilized drug designing approaches including retrieval tertiary structures both Cancer Type 1 Susceptibility Protein (BRCA1) viral protein, their validation generating Ramachandran Plots determining favoured amino acid residue angles prediction active residues. Furthermore, focused on molecular dynamics docking proteins, interpretation interactions between docked complex, well dynamic simulations (MD) addition MMGBSA binding energy calculations. A successful protein provided significant score 329.2 +/- 24.3, furthermore, MD showed high RMSD peak at 2.8 Å, RMSF were maximum 3.5 Å highest protein-protein interaction, radius gyration was stable simulation representing elastic stability interaction value - 7882 kCal/mol. Moreover, calculation results notable release free 68.96 kCal/mol demonstrating effective bond formation complex. propose effectiveness treat cancer. selected potential candidate specific virotherapy. computer-aided discovery presents targeting would assist reagents therapy.

Язык: Английский

Процитировано

1
The Role of Adjuvant Radiotherapy in Low-Risk Elderly Male Breast Cancer: Is Omission Justified? DOI Creative Commons
Chang Xu, Cheng Zeng,

Hang Meng

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Abstract Background The aim of our study is to evaluate the net survival benefit adjuvant radiotherapy following breast-conserving surgery (BCS) in elderly male patients with early-stage, low-risk breast cancer (node-negative, hormone receptor-positive [HR+]) and assess whether omitting might be a viable option based on observed outcomes. Methods We conducted retrospective cohort using data from SEER-17 registries (2000–2021), identifying 9,695 (MBC) patients. After applying inclusion criteria PSM, total 360 were included. Early-stage, categorized into (RT) non-radiotherapy (NRT) groups. A 1:3 nearest neighbor propensity score matching (PSM; caliper = 0.05) was used adjust for confounders. Estimate RT by overall (OS), relative (RS), standardized mortality ratio (SMR), transformed Cox regression, while controlling background mortality. Results In MBC underwent BCS, did not confer significant benifit compared those who omitted RT. PSM adjustment, 15-year OS, RS, SMR group 31.8%, 1.05, 2.14, respectively, no statistically differences when NRT (34.1%, 1.03, 2.25; p 0.36, 0.35, 0.81, respectively). Furthermore, cumulative incidence cancer-related death (BCRD) non-BCRD differ significantly between incidences BCRD 7.0% 61.2% group, 12.4% 53.5% (p 0.06 0.75, Additionally, demonstrated lower risk both OS RS within first 10 years diagnosis, although this benefits gradually diminished over time. Conclusions 65 T1 − 2N0M0, tumors, showed improvement overall, disease-specific, or survival. Therefore, may justified patients, aligning treatment individualized assessments.

Язык: Английский

Процитировано

0
Construction, validation, and visualization of a web-based nomogram to predict survival in male breast cancer patients with second primary prostate cancer DOI Open Access

Runsen Du,

Fangjian Shang, Xin Chen

и другие.

Gland Surgery, Год журнала: 2024, Номер 13(11), С. 2023 - 2042

Опубликована: Ноя. 1, 2024

The advancement of early detection and treatment has brought about a significant concern for male breast cancer (MBC) survivors-the emergence second primary malignancy (SPM) poses grave threat to their lives. Among them, prostate (spPCa) holds particular significance. This study aimed investigate the impact spPCa on prognosis MBC patients. We performed retrospective analysis using information from Surveillance, Epidemiology, End Results (SEER) database individuals diagnosed with who also experienced an SPM between 2000 2020. Propensity score matching (PSM) was employed balance baseline characteristics those non-prostate (non-PCa). participant survival assessed Kaplan-Meier method. Furthermore, two nomograms were developed, based univariate multifactor Cox regression analyses, predict overall (OS) cancer-specific (CSS). capacity evaluated concordance index (C-index), calibration curve, receiver operating characteristic (ROC) analysis, decision curve (DCA). Additionally, risk stratification system devised, taking into account cumulative each patient in nomogram. enrolled total 885 patients SPM, which 265 (29.9%) spPCa. Through PSM, 257 pairs eligible participants selected. Survival revealed that (PCa) as have longer OS CSS compared other types SPM. randomly divided training set validation ratio 7:3. proportional hazards model utilized assess factors associated outcomes. Two developed forecast 3-, 5-, 8-, 10-year had exhibited excellent performance terms C-index, ROC curves, plots, DCA demonstrating exceptional clinical discriminative ability predictive utility. In predicated nomogram, deemed high-risk diminished CSS. we created user-friendly web applications enhance accessibility nomogram practices, can be accessed at https://mbcpre.shinyapps.io/DynNomapp_OS/ https://mbcpre.shinyapps.io/DynNomapp_CSS/ exhibit more favorable than SPMs. constructed could accurately Patients whose are stratified should gain additional attention. Our may aid clinicians personalizing strategies supporting decisions.

Язык: Английский

Процитировано

0