Relationship Between the Gut Microbiome, Tryptophan-Derived Metabolites, and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis

Nutrients, Год журнала: 2025, Номер 17(2), С. 264 - 264

Опубликована: Янв. 12, 2025

Introduction: Osteoarthritis (OA) is the most prevalent form of arthritis and affects over 528 million people worldwide. Degenerative joint disease involves cartilage degradation, subchondral bone remodeling, synovial inflammation, leading to chronic pain, stiffness, impaired function. Initially regarded as a “wear tear” condition associated with aging mechanical stress, OA now recognized multifaceted influenced by systemic factors such metabolic syndrome, obesity, low-grade inflammation. Recent studies have focused on gut-joint axis investigate how gut microbiome modulates inflammation pain in OA. Materials Methods: A systematic review was conducted following PRISMA guidelines registered PROSPERO (CRD42024556265). This included involving adults symptomatic analyzed relationship between OA-related pain. Randomized non-randomized clinical trials, case reports, editorials, pilot were excluded. Searches performed PubMed, Cochrane Library, Web Science without publication date restrictions, filtered for “observational studies”. The study selection data extraction two independent researchers, risk bias assessed using appropriate tools. Results: Five observational review, three meta-analysis. Two reported an association different tryptophan metabolites levels patients other demonstrated correlation lipopolysaccharide fifth confirmed Streptococcus relative abundance spp. knee These results not supported meta-analysis, which found no significant presence bacilli genus or plasma markers pathway. Conclusions: Current evidence indicates potential link dysbiosis However, methodological limitations preclude definitive conclusions. Further research advanced techniques larger cohorts needed validate extend these findings elucidate underlying mechanisms. Targeted manipulation may be valuable strategy management patients.

Язык: Английский

Oxidative imbalance as a co-player in jaw functional limitations and biopsychosocial profile in patients with temporomandibular disorder—myofascial pain with referral

Frontiers in Neurology, Год журнала: 2025, Номер 15

Опубликована: Янв. 3, 2025

Temporomandibular disorders have a multifactorial etiology including biological, biomechanical, neuromuscular, and biopsychosocial factors. Current research on temporomandibular focuses identifying clinically relevant biomarkers thus creating new way of thinking about this dysfunction. The aim the study was to determine relationship between salivary/blood concentrations oxidative/nitrosative stress findings in patients with disorder-myofascial pain referral. sample enrolled total 26 individuals myofascial referral (twenty women, six men). procedure included clinical examination according Diagnostic Criteria for Disorders, saliva blood collection. Biochemical analysis concerned, among others, content reduced glutathione, uric acid, antioxidant capacity, advanced glycation end products, malondialdehyde, lipid hydroperoxides, kynurenine, N-formylkynurenine, peroxynitrite. All determinations were considered respect Patient Health Questionnaire-4 (PHQ-4), Questionnaire-9 (PHQ-9), Questionnaire-15 (PHQ-15), Generalized Anxiety Disorder-7 (GAD-7), Jaw Functional Limitation Scale-20 (JFLS-20), Perceived Stress Scale-10 (PSS-10), Beck Depression Inventory (BDI). average age participants 24.2 ± 1.23. High kynurenine N-formylkynurenine plasma related intensified psychological distress (PHQ-4) anxiety (GAD-7). Low concentration malondialdehyde hydroperoxides linked severe somatization (PHQ-15) respectively. Reduced levels non-enzymatic antioxidants associated greater jaw functional mobility restrictions as well limited mastication communication factor JFLS-20. These indicate that oxidative are significantly profile disorder.

Язык: Английский

Dysregulation of lipid metabolism, energy production, and oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Syndrome and fibromyalgia

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Март 10, 2025

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Gulf War Syndrome (GWS), and Fibromyalgia (FM) are complex, chronic illnesses with overlapping clinical features. Symptoms that reported across these conditions include post-exertional malaise (PEM), fatigue, pain, yet the etiology of remains largely unknown. Diagnosis is challenging in patients as definitive biomarkers lacking; required to meet criteria often undergo lengthy testing exclude other conditions, a process prolonged, costly, burdensome for patients. The identification reliable validated could facilitate earlier more accurate diagnosis drive development targeted pharmacological therapies might address underlying pathophysiology diseases. Major driving forces biomarker advancing fields metabolomics proteomics allow comprehensive characterization metabolites proteins biological specimens. Recent technological developments areas enable high-throughput analysis thousands from variety samples model systems, provides powerful approach unraveling metabolic phenotypes associated complex Emerging evidence suggests ME/CFS, GWS, FM all characterized by disturbances pathways, particularly those related energy production, lipid metabolism, oxidative stress. Altered levels key pathways have been studies highlighting potential common biochemical abnormalities. precise mechanisms altered remain be elucidated; however, elevated stress observed may contribute symptoms offer target therapeutic intervention. Investigating mechanisms, their role disease process, provide insights into pathogenesis reveal novel treatment targets. As such, metabolomic proteomic analyses crucial understanding in-order identify both common, unique, alterations serve diagnostic markers or

Язык: Английский