Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease DOI Open Access
Mona Abdelhamid, Scott Counts, Chunyu Zhou

и другие.

Nutrients, Год журнала: 2025, Номер 17(3), С. 558 - 558

Опубликована: Янв. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Язык: Английский

Multi-strain probiotics ameliorate Alzheimer’s-like cognitive impairment and pathological changes through the AKT/GSK-3β pathway in senescence-accelerated mouse prone 8 mice DOI

Qian Xiao-hang,

Chen Si-yue,

Huidong Tang

и другие.

Brain Behavior and Immunity, Год журнала: 2024, Номер 119, С. 14 - 27

Опубликована: Март 26, 2024

Язык: Английский

Процитировано

23
Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis DOI Creative Commons

Dah Ihm Kim,

Ki Hoon Lee, Amr Ahmed Gabr

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Год журнала: 2016, Номер 1863(11), С. 2820 - 2834

Опубликована: Сен. 9, 2016

Язык: Английский

Процитировано

169
Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3βPathway in Experimental Models of Alzheimer’s Disease DOI Creative Commons
Wen Yang, Yue Liu,

Qingqing Xu

и другие.

Oxidative Medicine and Cellular Longevity, Год журнала: 2020, Номер 2020, С. 1 - 17

Опубликована: Сен. 11, 2020

Alzheimer’s disease (AD) is the most common form of dementia characterized by progressive loss cognitive functions due to neuronal death mainly in hippocampal and cortical brain. Sulforaphene (SF) one main isothiocyanates isolated from a Chinese herb Raphani Semen. In this study, we aimed investigate neuroprotective effects SF using vitro vivo models AD. Streptozotocin (STZ) was intracranially injected into rats; then, (25 50 mg/kg) given orally once day for 6 consecutive weeks. After drug treatment, were assessed Morris Water Maze Test (MWMT). MWMT, rats euthanized brain tissues collected. test, BV-2 microglia pretreated with (1 2 μ M) 1 h then stimulated lipopolysaccharide (LPS) another 23 h. Both molecular histological methods used unravel action mechanisms elucidate signaling pathway. The MWMT results showed that treatment significantly improved STZ-induced deficits rats. markedly suppressed production tumor necrosis factor- α (TNF- ) interleukin-6 (IL-6) but increased release IL-10 STZ-treated addition, inhibited phosphorylation tau protein at Thr205, Ser396, Ser404 sites, while enhancing ratios p-Akt (Ser473)/Akt p-GSK-3 β (Ser9)/GSK-3 hippocampus On other hand, also attenuated cytotoxicity induced LPS cells. obviously releases nitric oxide (NO), TNF- , IL-6 LPS-stimulated Moreover, mitigated nuclear translocation p-NF- κ B p65 ratio Taken together, possessed against LPS-induced neuroinflammation cells via modulation PI3K/Akt/GSK-3 pathway inhibition NF- activation, suggesting promising agent worthy further development AD treatment.

Язык: Английский

Процитировано

134
Inverse relationship between Alzheimer’s disease and cancer, and other factors contributing to Alzheimer’s disease: a systematic review DOI Creative Commons
Ovais Shafi

BMC Neurology, Год журнала: 2016, Номер 16(1)

Опубликована: Ноя. 22, 2016

The AD etiology is yet not properly known. Interactions among environmental factors, multiple susceptibility genes and aging, contribute to AD. This study investigates the factors that play role in causing how changes cellular pathways PUBMED database, MEDLINE database Google Scholar were searched with no date restrictions for published articles involving roles cancers, cell survival, growth, proliferation, development, also contributing Alzheimer’s disease. research explores inverse relationship between cancer, other behind using several already literature find of Cancer disease have many aspects such as P53, estrogen, neurotrophins growth cAMP, EGFR, Bcl-2, apoptosis pathways, IGF-1, HSV, TDP-43, APOE variants, notch signals presenilins, NCAM, TNF alpha, PI3K/AKT/MTOR pathway, telomerase, ROS, ACE levels. occurs when brain neurons weakened survival responses, maintenance mechanisms, anti-stress responses Vimentin, Carbonic anhydrases, HSPs, SAPK. In these are upregulated maintained. Evolutionarily conserved mechanisms FOXO impaired Countermeasures or compensatory by affected Tau, Beta Amyloid, S100, last attempts which may be protective certain time, can speed up microenvironment via C-ABL activation, GSK3, neuro-inflammation. relationship; any cancer sustain downregulated neuro-degeneration. When aged genetically susceptible age related gene expression changes, altered regulation death they Amyloid Plaques, NFTs, this provides neuroprotection time ultimately become pathological developing new potential diagnostic tests, interventions treatments.

Язык: Английский

Процитировано

114
Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway DOI
Ahmed S. Kamel, Noha F. Abdelkader,

Sahar S. Abd El‐Rahman

и другие.

Molecular Neurobiology, Год журнала: 2018, Номер 55(10), С. 8188 - 8202

Опубликована: Март 7, 2018

Язык: Английский

Процитировано

102
Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3β Pathway by Hesperidin in Wistar Rats DOI

Arokiasamy Justin‐Thenmozhi,

Mathiyazahan Dhivya Bharathi,

Ramaraj Kiruthika

и другие.

Neurotoxicity Research, Год журнала: 2018, Номер 34(3), С. 463 - 476

Опубликована: Апрель 23, 2018

Язык: Английский

Процитировано

99
Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease DOI Creative Commons

Kuan-I Lee,

Hsueh‐Te Lee, Hui‐Ching Lin

и другие.

Journal of Neuroinflammation, Год журнала: 2016, Номер 13(1)

Опубликована: Апрель 27, 2016

Transient receptor potential ankyrin 1 (TRPA1) channel plays an important role in pain and inflammation. However, little is known about the significance of TRPA1 pathophysiology Alzheimer's disease (AD).Wild-type (WT), TRPA1(-/-), amyloid precursor protein (APP)/presenilin (PS1) transgenic (APP/PS1 Tg) mice, mouse model AD, APP/PS1 Tg/TRPA1(-/-) mice were used to examine pathogenesis AD. Western blot was for expression; immunohistochemistry histological examination. The behaviors evaluated by locomotion, nesting building, Y-maze Morris water maze tests; levels interleukin (IL)-1β, IL-4, IL-6 IL-10 activities phosphatase 2B (PP2B), NF-κB nuclear factor activated T cells (NFAT) measured conventional assay kits; Fluo-8 NW calcium (Ca(2+)) kit measurement intracellular Ca(2+) level primary astrocytes HEK293 cells.The expression channels higher brains, mainly hippocampus, from Tg than WT mice. Ablation TRPA1-channel function alleviated behavioral dysfunction, Aβ plaque deposition pro-inflammatory cytokine production but increased astrogliosis brain lesions. influx elicited both TRPA1-transfected treated with fibrilized Aβ1-42; these abrogated pharmacological inhibition activity, disruption or removal extracellular Ca(2+). Inhibition activity exacerbated Aβ1-42-induced inhibited Aβ1-42-increased PP2B activation, cytokines transcriptional factors NFAT Pharmacological diminished cytokines, activation astrocytes.TRPA1 - signaling may play a crucial regulating astrocyte-derived inflammation

Язык: Английский

Процитировано

91
Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications DOI

Seyede Nazanin Zarneshan,

Sajad Fakhri, Mohammad Hosein Farzaei

и другие.

Food and Chemical Toxicology, Год журнала: 2020, Номер 145, С. 111714 - 111714

Опубликована: Авг. 30, 2020

Язык: Английский

Процитировано

84
In-depth Site-specific Analysis of N-glycoproteome in Human Cerebrospinal Fluid and Glycosylation Landscape Changes in Alzheimer's Disease DOI Creative Commons
Zhengwei Chen,

Qinying Yu,

Qing Yu

и другие.

Molecular & Cellular Proteomics, Год журнала: 2021, Номер 20, С. 100081 - 100081

Опубликована: Янв. 1, 2021

As the body fluid that directly interchanges with extracellular of central nervous system (CNS), cerebrospinal (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted CSF, but studies aimed at unraveling site-specific CSF N-glycoproteome are lacking. Initial efforts into N-glycoproteomics study in yield limited coverage, hindering further experimental design glycosylation-based discovery CSF. In present study, we have developed an N-glycoproteomic approach combines enhanced N-glycopeptide sequential enrichment by hydrophilic interaction chromatography (HILIC) and boronic acid electron transfer higher-energy collision dissociation (EThcD) large-scale intact analysis. The application to analyses human samples enabled identifications total 2893 N-glycopeptides from 511 N-glycosites 285 N-glycoproteins. To our knowledge, this is largest dataset reported date. Such provides molecular basis better understanding structure-function relationships glycoproteins their roles physiological pathological processes. accumulating evidence suggests defects glycosylation involved Alzheimer's (AD) pathogenesis, comparative in-depth analysis was healthy control AD patients, which yielded comparable coverage distinct expression pattern different categories glycoforms, such decreased fucosylation samples. Altered patterns were detected number N-glycoproteins including alpha-1-antichymotrypsin, ephrin-A3 carnosinase CN1 etc., serve potentially interesting targets may eventually lead elucidation role progression.

Язык: Английский

Процитировано

64
Impact of benzo[a]pyrene with other pollutants induce the molecular alternation in the biological system: Existence, detection, and remediation methods DOI
Kandasamy Saravanakumar,

Sugavaneswaran Siva Santosh,

Anbazhagan Sathiyaseelan

и другие.

Environmental Pollution, Год журнала: 2022, Номер 304, С. 119207 - 119207

Опубликована: Март 26, 2022

Язык: Английский

Процитировано

44