Frontiers in Chemistry,
Год журнала:
2023,
Номер
11
Опубликована: Янв. 30, 2023
The
toxicity
of
and
resistance
to
platinum
complexes
as
cisplatin,
oxaliplatin
or
carboplatin
calls
for
the
replacement
these
therapeutic
agents
in
clinical
settings.
We
have
previously
identified
a
set
half
sandwich-type
osmium,
ruthenium
iridium
with
bidentate
glycosyl
heterocyclic
ligands
exerting
specific
cytostatic
activity
on
cancer
cells
but
not
non-transformed
primary
cells.
apolar
nature
complexes,
conferred
by
large,
benzoyl
protective
groups
hydroxyl
carbohydrate
moiety,
was
main
molecular
feature
induce
cytostasis.
exchanged
straight
chain
alkanoyl
varying
length
(3
7
carbon
units)
that
increased
IC50
value
compared
benzoyl-protected
rendered
toxic.
These
results
suggest
need
aromatic
molecule.
pyridine
moiety
ligand
quinoline
group
enlarge
surface
This
modification
decreased
complexes.
containing
[(η6-p-cymene)Ru(II)],
[(η6-p-cymene)Os(II)]
[(η5-Cp*)Ir(III)]
were
biologically
active
unlike
complex
[(η5-Cp*)Rh(III)].
ovarian
(A2780,
ID8),
pancreatic
adenocarcinoma
(Capan2),
sarcoma
(Saos)
lymphoma
cell
lines
(L428),
dermal
fibroblasts
their
dependent
reactive
oxygen
species
production.
Importantly,
cisplatin-resistant
A2780
similar
values
cisplatin-sensitive
In
addition,
quinoline-containing
Ru
Os
short
alkanoyl-modified
(C3
C4)
proved
be
bacteriostatic
multiresistant
Gram-positive
Enterococcus
Staphylococcus
aureus
isolates.
Hereby,
we
submicromolar
low
micromolar
inhibitory
constants
against
wide
range
cells,
including
resistant
bacteria.
Cellular and Molecular Life Sciences,
Год журнала:
2022,
Номер
79(5)
Опубликована: Апрель 16, 2022
Abstract
Bile
acids
are
soluble
derivatives
of
cholesterol
produced
in
the
liver
that
subsequently
undergo
bacterial
transformation
yielding
a
diverse
array
metabolites.
The
bulk
bile
acid
synthesis
takes
place
primary
acids;
however,
other
tissues
have
also
capacity
to
generate
(e.g.
ovaries).
Hepatic
then
transported
and
released
into
intestines.
In
large
intestine,
fraction
is
converted
secondary
by
gut
bacteria.
majority
intestinal
reuptake
return
liver.
A
small
remains
circulation
exert
receptor-mediated
pure
chemical
effects
acidic
oesophageal
cancer)
on
cancer
cells.
this
review,
we
assess
how
changes
biosynthesis,
flux
local
concentration
modulate
behavior
different
cancers.
Here,
present
in-depth
involvement
oesophageal,
gastric,
hepatocellular,
pancreatic,
colorectal,
breast,
prostate,
ovarian
cancer.
Previous
studies
often
used
supraphysiological
concentration,
sometimes
concentrations
1000
times
higher
than
highest
reported
tissue
or
serum
likely
eliciting
unspecific
effects,
practice
advocate
against
review.
Furthermore,
show
that,
although
were
classically
considered
as
pro-carcinogenic
agents
cancer),
dogma
switch,
lower
correspond
their
reference
possess
anticancer
activity
subset
Differences
response
cancers
lie
differential
expression
receptors
between
FXR
vs.
TGR5).
UDCA,
sold
generic
medication
cholestasis
biliary
surge,
its
conjugates
identified
with
almost
purely
features
suggesting
possibility
for
drug
repurposing.
Taken
together,
tumor
inducers
promoter
molecules;
nevertheless,
certain
cancers,
like
breast
cancer,
may
act
suppressors
Janus-faced
nature
carcinogenesis.
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 895 - 909
Опубликована: Янв. 1, 2025
Ovarian
cancer
(OC)
remains
one
of
the
most
lethal
gynecological
malignancies,
largely
due
to
its
late-stage
diagnosis
and
high
recurrence
rates.
Chronic
inflammation
is
a
critical
driver
OC
progression,
contributing
immune
evasion,
tumor
growth,
metastasis.
Inflammatory
cytokines,
including
IL-6,
TNF-α,
IL-8,
as
well
key
signaling
pathways
such
nuclear
factor
kappa
B
(NF-kB)
signal
transducer
activator
transcription
3
(STAT3),
are
upregulated
in
OC,
promoting
tumor-promoting
environment.
The
microenvironment
(TME)
characterized
by
cells
like
tumor-associated
macrophages
(TAMs)
regulatory
T
(Tregs),
which
suppress
anti-tumor
responses,
facilitating
evasion.
Furthermore,
utilize
checkpoint
pathways,
PD-1/PD-L1,
inhibit
cytotoxic
cell
activity.
Targeting
these
inflammatory
evasion
mechanisms
offers
promising
therapeutic
strategies.
COX-2
inhibitors,
Janus
kinase/signal
(JAK/STAT)
pathway
blockers,
NF-kB
inhibitors
have
shown
potential
preclinical
studies,
while
targeting
PD-1/PD-L1
CTLA-4
been
explored
with
mixed
results
OC.
Additionally,
emerging
research
on
microbiome
inflammation-related
biomarkers,
microRNAs
(miRNAs)
exosomes,
points
new
opportunities
for
early
detection
precision
medicine.
Future
approaches
treatment
must
focus
personalized
strategies
that
target
TME,
integrating
anti-inflammatory
therapies
immunotherapy
enhance
patient
outcomes.
Continued
into
interplay
between
essential
developing
effective,
long-lasting
treatments.
Cancers,
Год журнала:
2022,
Номер
14(12), С. 2885 - 2885
Опубликована: Июнь 11, 2022
With
a
5-year
survival
rate
of
less
than
50%,
ovarian
high-grade
serous
carcinoma
(HGSC)
is
one
the
most
highly
aggressive
gynecological
malignancies
affecting
women
today.
The
high
mortality
HGSC
largely
attributable
to
delays
in
diagnosis,
as
patients
remain
undiagnosed
until
late
stages
-disease.
There
are
currently
no
recommended
screening
tests
for
cancer
and
there
thus
remains
an
urgent
need
new
diagnostic
methods,
particularly
those
that
can
detect
disease
at
early
when
clinical
intervention
effective.
While
diagnostics
share
many
same
technical
hurdles
other
types,
low
prevalence
general
population,
coupled
with
notable
lack
sensitive
specific
biomarkers,
have
made
development
clinically
useful
strategy
challenging.
Here,
we
present
detailed
review
overall
landscape
diagnostics,
emphasis
on
emerging
methods
employ
novel
protein,
genetic,
epigenetic
imaging-based
biomarkers
and/or
advanced
technologies
noninvasive
detection
HGSC,
risk
due
germline
mutations
such
BRCA1/2.
Lastly,
discuss
translational
potential
these
approaches
achieving
implementable
solution
early-stage
means
ultimately
improving
patient
outcomes
both
high-risk
populations.
Frontiers in Reproductive Health,
Год журнала:
2022,
Номер
4
Опубликована: Авг. 9, 2022
The
intricate
interactions
between
the
host
cells,
bacteria,
and
immune
components
that
reside
in
female
reproductive
tract
(FRT)
are
essential
maintaining
homeostasis.
Much
of
our
current
knowledge
surrounding
FRT
microbiota
relates
to
vaginal
microbiota,
where
‘health’
has
long
been
associated
with
low
bacterial
diversity
Lactobacillus
dominance.
This
concept
recently
challenged
as
women
can
have
a
diverse
microbial
composition
absence
symptomatic
disease.
structures
upper
(the
endocervix,
uterus,
Fallopian
tubes,
ovaries)
distinct,
lower
biomass
microbiotas
than
vagina;
however,
existence
permanent
at
these
sites
is
disputed.
During
homeostasis,
balance
exists
bacteria
system
maintains
quiescence.
Alterations
system,
or
local
environment
may
result
perturbances
defined
dysbiosis.
inflammatory
signature
perturbed
“dysbiotic”
characterized
by
elevated
concentrations
pro-inflammatory
cytokines
cervical
fluid.
It
appears
homeostasis
be
disrupted
two
different
mechanisms:
first,
shift
toward
increased
trigger
inflammation,
second,
immunity
altered
some
manner,
which
disrupts
response
an
environmental
change.
dysbiosis
negative
effects
on
health.
review
will
examine
increasing
evidence
for
involvement
inflammation
gynecologic
conditions
such
endometriosis,
infertility,
endometrial
ovarian
cancer;
precise
mechanisms
involved
remains
speculative
present.
While
only
their
infancy,
use
antibiotics
probiotics
therapeutically
alter
being
studied
discussed
herein.
Our
understanding
intimate
relationship
its
early
days,
more
research
needed
deepen
mechanistic
this
assess
how
present
harnessed
assist
diagnosis
treatment
conditions.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 15, 2022
Commensal
bacteria
and
other
microorganisms
that
reside
in
the
human
body
are
closely
associated
with
development
treatment
of
cancers.
Recently,
tumor
microbiome
(TM)
has
been
identified
a
variety
cancers
such
as
pancreatic,
lung,
breast
TM
different
compositions
tumors
effects
on
tumors.
plays
an
important
role
formation
microenvironment,
regulation
local
immunity,
modification
cell
biology,
directly
affects
efficacy
drug
for
is
expected
to
be
biomarker
tumors,
engineered
tumor-targeting
anti-cancer
microbial
agents
(GEN-001)
have
This
paper
reviews
relevant
studies
recent
years
describes
its
distribution
correlation
clinical
features,
effect
research
directions
treatment.
Life,
Год журнала:
2022,
Номер
12(4), С. 495 - 495
Опубликована: Март 28, 2022
During
space
missions,
astronauts
are
faced
with
a
variety
of
challenges
that
unique
to
spaceflight
and
have
been
known
cause
physiological
changes
in
humans
over
period
time.
Several
these
occur
at
the
microbiome
level,
complex
ensemble
microbial
communities
residing
various
anatomic
sites
human
body,
pivotal
role
regulating
health
behavior
host.
The
is
essential
for
day-to-day
activities,
alterations
composition
function
linked
diseases.
For
reasons,
understanding
impact
conditions
on
important
assess
significant
risks
can
emerge
during
long-term
missions
develop
countermeasures.
Here,
we
review
caused
by
exploration
discuss
promoting
or
ameliorating
conditions,
as
well
space-related
factors
composition.
topics
explored
pertain
microgravity,
radiation,
immunity,
bone
health,
cognitive
function,
gender
differences
pharmacomicrobiomics.
Connections
made
between
trifecta
spaceflight,
host
microbiome,
significance
interactions
successful
missions.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Янв. 13, 2023
Abstract
Ovarian
cancer
(OC)
is
the
second
most
common
gynecological
malignancy
and
fifth
leading
cause
of
death
due
to
in
women
United
States
mainly
late-stage
diagnosis
this
cancer.
It
is,
therefore,
critical
identify
potential
indicators
aid
early
detection
disease.
We
investigated
microbiome
associated
with
OC
its
role
detection,
progression
as
well
prognosis
identified
a
distinct
general
enrichment
several
microbial
taxa,
including
Dialister
,
Corynebacterium
Prevotella
Peptoniphilus
cohort
all
body
sites
excluding
stool
omentum
which
were
not
sampled
from
benign
cohort.
These
taxa
were,
however,
depleted
advanced-stage
high-grade
patients
compared
early-stage
low-grade
suggestive
decrease
accumulation
advanced
disease
could
serve
for
OC.
Similarly,
we
also
observed
these
pathogenic
adverse
treatment
outcomes
those
without
events
predicting
patients’
responses
treatment.
findings
provide
important
insights
into
use
(1)
screening
(2)
response
Given
limited
number
enrolled
study,
results
would
need
be
further
confirmed
larger
study.
Frontiers in Nutrition,
Год журнала:
2023,
Номер
10
Опубликована: Июнь 21, 2023
Tryptophan
(Trp)
is
an
essential
amino
acid
that
can
be
metabolized
via
endogenous
and
exogenous
pathways,
including
the
Kynurenine
Pathway,
5-Hydroxyindole
Pathway
(also
Serotonin
pathway),
Microbial
pathway.
Of
these,
Trp
metabolic
pathways
in
gut
have
recently
been
extensively
studied
for
their
production
of
bioactive
molecules.
The
microbiota
plays
important
role
host
metabolism
immunity,
microbial
metabolites
influence
development
progression
various
diseases,
inflammatory,
cardiovascular
neurological
cancer,
by
mediating
body’s
immunity.
This
review
briefly
outlines
crosstalk
between
microorganisms
body,
starting
from
three
Trp.
mechanisms
which
act
on
organism
immunity
are
summarized,
potential
implications
disease
prevention
treatment
highlighted.
Microbiology Spectrum,
Год журнала:
2023,
Номер
11(2)
Опубликована: Март 28, 2023
Microbiota
can
influence
the
occurrence,
development,
and
therapeutic
response
of
a
wide
variety
cancer
types
by
modulating
immune
responses
to
tumors.
Recent
studies
have
demonstrated
existence
intratumor
bacteria
inside
ovarian
(OV).
However,
whether
microbes
are
associated
with
tumor
microenvironment
(TME)
prognosis
OV
still
remains
unknown.
The
RNA-sequencing
data
clinical
survival
373
patients
in
Cancer
Genome
Atlas
(TCGA)
were
collected
downloaded.
According
knowledge-based
functional
gene
expression
signatures
(Fges),
was
classified
into
two
subtypes,
termed
immune-enriched
immune-deficient
subtypes.
subtype,
which
had
higher
infiltration
enriched
CD8+
T
cells
M1
type
macrophages
(M1)
mutational
burden,
exhibited
better
prognosis.
Based
on
Kraken2
pipeline,
microbiome
profiles
explored
found
be
significantly
different
between
A
prediction
model
consisting
32
microbial
constructed
using
Cox
proportional-hazard
showed
great
prognostic
value
for
patients.
strongly
hosts'
factors.
Especially,
five
species
(Achromobacter
deleyi
Microcella
alkaliphila,
Devosia
sp.
strain
LEGU1,
Ancylobacter
pratisalsi,
Acinetobacter
seifertii).
Cell
experiments
that
seifertii
inhibit
macrophage
migration.
Our
study
could
subtypes
intratumoral
microbiota
Furthermore,
closely
IMPORTANCE
microorganisms.
role
development
their
interaction
largely
-deficient
enrichment
subtype
Microbiome
analysis
an
independent
predictor
interact
expression.
microbes,
Together,
findings
our
highlight
important
roles
TME
OV,
paving
way
further
investigation
its
underlying
mechanisms.
Human Nutrition & Metabolism,
Год журнала:
2024,
Номер
36, С. 200256 - 200256
Опубликована: Март 8, 2024
Short
chain
fatty
acids
(SCFA)
have
been
linked
to
women's
reproductive
health,
though
a
lesser
extent,
alteration
in
the
production
of
SCFA
and
SCFA-producing
bacteria
has
associated
significantly
with
pregnancy-related
complications,
unfavourable
pregnancy
outcomes,
menstrual
anomalies,
gynaecological
cancer.
The
female
system
is
delicate,
intricate,
hormone-dependent
group
tissues
required
for
continuity
life
species'
survival.
Reproductive
health
impacts
ovarian
function
implantation
foetal
development.
Several
environmental
physiological
factors
contribute
mammalian
infertility
concerns
caused
by
change
status.
lifestyle
demonstrated
affect
including
age,
body
weight,
smoking,
alcohol
consumption,
work
stress,
exercise,
diet,
nutrition.
Nutrition
influences
puberty,
cycle,
ovulation,
conception,
early
This
review
provides
an
overview
how
intestinal
derived
SCFAs
maintains
summarizing
current
knowledge
future
perspectives.
Microbial
improve
human
metabolism
interfering
with,
glucose
homeostasis,
appetite
regulation
lipid
metabolism.
Also
host
immunity
barrier
integrity
via
primary
inhibition
Histone
deacetylases
(HDAC)
mechanism.
Therefore,
exhibit
anti-inflammatory,
anti-obesity,
immunoregulatory,
anti-diabetes,
anti-cancer,
hepatoprotective,
cardiovascular
protective
neuroprotective
properties.
highlights
recent
findings
on
pathologies
such
as
preeclampsia,
gestational
diabetes,
polycystic
ovary
syndrome,
bacterial
vaginosis,
endometriosis
describe
relationship
between
disease
women.