Traditional Chinese medicine in lung cancer treatment
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 26, 2025
Lung
cancer
remains
a
major
global
health
challenge
and
one
of
the
leading
causes
cancer-related
deaths
worldwide.
Despite
significant
advancements
in
treatment,
challenges
such
as
drug
resistance,
side
effects,
metastasis
recurrence
continue
to
impact
patient
outcomes
quality
life.
In
response,
there
is
growing
interest
complementary
integrative
approaches
care.
Traditional
Chinese
medicine
(TCM),
with
its
long
history,
abundant
clinical
experience,
holistic
perspective
individualized
approach,
has
garnered
increasing
attention
for
role
lung
prevention
management.
This
review
provides
comprehensive
overview
advances
TCM
covering
theoretical
foundation,
treatment
principles,
experiences
evidence
supporting
efficacy.
We
also
provide
systematic
summary
preclinical
mechanisms,
through
which
impacts
cancer,
including
induction
cell
death,
reversal
inhibition
modulation
immune
responses.
Additionally,
future
prospects
are
discussed,
offering
insights
into
expanded
application
integration
modern
address
this
challenging
disease.
Язык: Английский
From natural herbal wisdom to nano innovation: Revolutionizing tumor treatment through metabolic reprogramming
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2025,
Номер
unknown, С. 189263 - 189263
Опубликована: Янв. 1, 2025
Язык: Английский
Elucidating the role of lipid metabolism dysregulation in the transition from oral lichen planus to oral squamous cell carcinoma
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 16, 2025
Oral
Lichen
Planus
(OLP)
is
a
chronic
inflammatory
disorder
that
may
progress
to
Squamous
Cell
Carcinoma
(OSCC).
Lipid
metabolism
dysregulation
has
been
implicated
in
tumor
development
and
immune
response
modulation.
This
study
aims
explore
the
role
of
lipid
metabolism,
particularly
lipids
diacylglycerol
(DAG),
triacylglycerol
(TAG),
phosphatidylcholine
(PC),
progression
from
OLP
OSCC,
identify
potential
therapeutic
targets
for
prevention
treatment.
We
performed
Mendelian
randomization
(MR)
analysis
investigate
causal
relationships
between
risk
OSCC.
Differential
gene
expression
was
conducted
key
genes
related
metabolism.
The
interactions
species
were
examined
using
drug
databases
(DrugBank,
DGIdb,
TCMSP)
candidates.
Enrichment
signaling
pathways,
including
PPAR
signaling,
also
understand
underlying
mechanisms.
Our
MR
revealed
DAG
exerts
protective
effect
(OR
<
1),
but
its
shifts
factor
OSCC
>
potentially
by
altering
microenvironment.
TAG
PI
plays
critical
tumorigenesis.
Gene
identified
several
metabolism-related
genes,
SLC27A6,
FABP3,
FABP4,
ADIPOQ,
PLIN1,
whose
differed
highlighting
their
importance
progression.
These
enriched
pathway,
suggesting
involvement
growth
Potential
candidates,
such
as
palm
acid
(PA),
Imatinib,
Curcumin,
through
drug-repurposing
strategies.
crucial
Targeting
pathways
DAG,
TAG,
PI,
offer
promising
strategies
early
diagnosis
intervention.
provides
novel
insights
into
molecular
mechanisms
OLP-to-OSCC
suggests
natural
compounds,
future
clinical
applications.
Further
research
needed
validate
these
findings
settings.
Not
applicable.
Язык: Английский
Ginsenosides in cancer: Proliferation, metastasis, and drug resistance
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117049 - 117049
Опубликована: Июнь 29, 2024
Ginseng,
the
dried
root
of
Panax
ginseng
C.A.
Mey.,
is
widely
used
in
Chinese
herbal
medicine.
Ginsenosides,
primary
active
components
ginseng,
exhibit
diverse
anticancer
functions
through
various
mechanisms,
such
as
inhibiting
tumor
cell
proliferation,
promoting
apoptosis,
and
suppressing
invasion
migration.
In
this
article,
mechanism
action
20
ginsenoside
subtypes
therapy
research
progress
multifunctional
nanosystems
are
reviewed,
order
to
provide
reference
for
clinical
prevention
treatment
cancer.
Язык: Английский
Curcumin-Dichloroacetate Hybrid Molecule as an Antitumor Oral Drug against Multidrug-Resistant Advanced Bladder Cancers
Cancers,
Год журнала:
2024,
Номер
16(17), С. 3108 - 3108
Опубликована: Сен. 8, 2024
Tumor
cells
produce
excessive
reactive
oxygen
species
(ROS)
but
cannot
detoxify
ROS
if
they
are
due
to
an
external
agent.
An
agent
that
produces
toxic
levels
of
ROS,
specifically
in
tumor
cells,
could
be
effective
anticancer
drug.
CMC-2
is
a
molecular
hybrid
the
bioactive
polyphenol
curcumin
conjugated
dichloroacetate
(DCA)
via
glycine
bridge.
The
was
tested
for
its
cytotoxic
antitumor
activities
and
killed
both
naïve
multidrug-resistant
(MDR)
bladder
cancer
(BCa)
with
equal
potency
(<1.0
µM);
about
10-15
folds
more
potent
than
or
DCA.
Growth
human
BCa
xenograft
mice
reduced
by
>50%
oral
gavage
50
mg/kg
without
recognizable
systemic
toxicity.
Doses
used
DCA
showed
minimum
effects.
In
vitro,
toxicity
MDR
depended
on
increased
intracellular
not
normal
at
comparable
doses.
Increased
caused
permeabilization
mitochondria
induced
apoptosis.
Further,
adding
N-Acetyl
cysteine
(NAC),
hydroxyl
radical
scavenger,
abolished
production
CMC-2's
cytotoxicity.
lack
toxicity,
against
chemotherapy
-naïve
resistant
tumors,
bioavailability
establish
potential
as
drug
cancers.
Язык: Английский