Adoptive transfer of natural killer cells in therapeutic treatment of COVID-19 patients
Egyptian Journal of Medical Human Genetics,
Год журнала:
2025,
Номер
26(1)
Опубликована: Фев. 22, 2025
Abstract
Background
Natural
killer
(NK)
cells
are
crucial
constituents
of
innate
immunity,
playing
a
vital
role
in
the
early
defense
against
viral
infections
and
cancer.
Their
antiviral
capabilities
stem
from
direct
cytotoxic
activity
infected
immunoregulatory
functions
that
modulate
adaptive
immune
responses.
In
context
Coronavirus
disease
(COVID-19),
NK
contribute
to
controlling
replication
limiting
excessive
inflammatory
Aims
This
review
highlights
mechanisms
underlying
cell-mediated
activity,
focusing
on
their
interactions
with
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‑CoV‑2).
We
discuss
potential
sources
for
adoptive
transfer
therapy,
critical
factors
influencing
therapeutic
efficacy,
considerations
clinical
translation
COVID-19
treatment.
Methods
Various
cell
therapy
discussed,
including
peripheral
blood,
cord
genetically
engineered
cells.
Key
efficacy
safety
cell-based
therapies
analyzed,
cytokine
modulation,
subset
selection,
delivery
methods.
Conclusion
Understanding
influence
success
can
inform
design
more
effective
immunotherapies
patients.
Strategies
improving
function,
such
as
genetic
modification
optimizing
protocols,
highlighted
enhance
outcomes.
Graphical
neutralize
SARS-CoV-2
by
releasing
granules,
inhibiting
replication,
modulating
inflammation.
They
originate
engineering.
Therapeutic
strategies
include
transfer,
optimized
delivery.
Inflammation
is
controlled,
reducing
Язык: Английский
Association between SARS-CoV-2 viral load and serum biomarkers with mortality in Mexican patients
Journal of Education and Health Promotion,
Год журнала:
2025,
Номер
14(1)
Опубликована: Март 1, 2025
BACKGROUND:
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
resulted
in
high
mortality
among
hospitalized
patients;
thus,
identifying
markers
treating
these
patients
is
essential.
To
evaluate
the
association
between
viral
load
and
serum
biomarkers
with
COVID-19.
MATERIALS
AND
METHODS:
A
retrospective
cohort
study
was
conducted
198
inpatient
records
from
a
tertiary
hospital
Mexico
City
January
April
2021.
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
death
due
to
COVID-19
assessed
using
Cox
regression
models.
RESULTS:
median
age
54.9
years,
61.6%
were
males.
rate
43.4%.
After
adjusting
for
potential
confounders,
higher
[adjusted
hazard
ratio
(aHR)
=
1.56;
95%
confidence
interval
(95%
CI)
1.01,
2.42;
P
value
0.041];
concentrations
of
BUN
(aHR
4.87;95%
CI
2.70,
8.79;
0.001),
creatinine
1.60;95%
2.54;
0.043),
osmolality
4.37;95%
2.34,
8.14;
glucose
2.41;95%
1.40,
4.18;
0.001)
more
likely
have
fatal
prognosis.
Conversely,
risk
lower
lymphocytes
0.47;95%
0.30,
0.72;
0.001).
CONCLUSION:
SARS-CoV-2
such
as
BUN,
creatinine,
glucose,
osmolarity,
could
help
physicians
identify
individuals
who
require
closer
monitoring.
Язык: Английский
Online and Face-to-Face Mat Pilates Training for Long COVID-19 Patients: A Randomized Controlled Trial on Health Outcomes
International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
21(10), С. 1385 - 1385
Опубликована: Окт. 19, 2024
This
study
investigated
the
impacts
of
online
and
face-to-face
Mat
Pilates
training
in
adults
with
persistent
symptoms
long
COVID
on
health
outcomes.
Forty-nine
patients
(52
±
5.85
yr.)
diagnosed
related
to
fatigue
were
randomly
included
three
groups:
(n
=
16),
15),
a
control
group
18)
without
training.
was
conducted
times
week
for
12
weeks.
Fatigue,
functional
capacity,
anthropometrics,
body
composition,
cardiometabolic
markers
assessed
before
after
interventions.
Two-factor
Generalized
Estimating
Equation
analyses
identified
significant
differences
Bonferroni
post
hoc
testing
(
Язык: Английский
Implication of iron overload in COVID-19 pathogenesis and long COVID: a mechanistic review
Future Virology,
Год журнала:
2024,
Номер
19(14-15), С. 525 - 538
Опубликована: Окт. 12, 2024
COVID-19
causes
cytokine
storm
which
results
in
altered
iron
homeostasis
within
the
system.
The
negative
consequences
of
this
include
poor
metabolism,
ROS-induced
oxidative
damage,
ferroptosis,
and
increased
severity
along
with
illnesses
like
anemia,
thalassemia,
diabetes,
cancer,
neurological
disorders,
long
COVID.
Therefore,
managing
overload
natural
or
synthetic
chelators
alternative
therapeutics
can
help
to
reduce
COVID-19.
This
review
analyzes
intricate
molecular
mechanism
dynamics
during
SARS-CoV-2
infection
disease
progression
patients
related
clinical
consequences.
Also,
explores
a
comprehensive
understanding
reciprocal
between
their
adverse
effects,
thereby
facilitating
development
potential
therapeutic
interventions.
Язык: Английский
Evaluation of soluble fms-like thyroxine kinase-1 and endo-thelial antibodies in patients with acute coronary syndrome in the post-COVID period
Saratov Journal of Medical Scientific Research,
Год журнала:
2024,
Номер
20(4)
Опубликована: Дек. 31, 2024
Objective:
to
evaluate
the
role
of
soluble
fms-like
thyroxine
kinase-1
and
endothelial
factor
in
patients
with
acute
coronary
syndrome
post-COVID
period.
Material
methods.
The
study
included
118
(including
57
women
61
men)
COVID-19
history.
Soluble
were
determined
all
patients.
comparison
group
consisted
121
without
COVID-19.
Results.
High
levels
antibodies
endothe-lium
more
often
detected
ACS
previous
than
(risk
ratio
—
RR=2.768
[95%
confidence
interval
Cl:
2.0810-3.681];
p<0.001)
(RR=1,554
1.216-1.987];
p=0.002),
respectively.
In
COVID-19,
a
severe
course
was
also
observed:
rhythm
disturbances
recorded
(RR=1.372
1.005-1.784];
p=0.032),
rehospitalization
first
14
days
for
cardiovascular
diseases
(RR=1.475
1.100-1.977];
p=0.032)
hospital
mortality
(RR=1.610
1.160-2.233];
p=0.042).
Conclusion.
obtained
data
allow
us
say
that
anti-endothelial
are
associated
risk
developing
Язык: Английский