Epidemiological and Antimicrobial Resistance Trends in Bacterial Keratitis: A Hospital-Based 10-Year Study (2014–2024) DOI Creative Commons

Qingquan Shi,

Dongyu Mao,

Zijun Zhang

и другие.

Microorganisms, Год журнала: 2025, Номер 13(3), С. 670 - 670

Опубликована: Март 17, 2025

Bacterial keratitis (BK) is a severe ocular infection that can lead to vision loss, with antimicrobial resistance (AMR) posing growing challenge. This study retrospectively analyzed 1071 bacterial isolates from corneal infections over 10-year period (2014–2024) at tertiary ophthalmic center in Beijing, categorizing them into three distinct phases: pre-COVID-19, during COVID-19, and post-COVID-19. The results indicated significant changes pathogen distribution, including marked decrease Gram-positive cocci (from 69.8% pre-COVID-19 49.3% post-COVID-19, p < 0.001), particularly Staphylococcus epidermidis. In contrast, bacilli, Corynebacterium spp., increased 4.2% 16.1% (p 0.001). susceptibility gatifloxacin, moxifloxacin, ciprofloxacin significantly declined both bacilli the COVID-19 (all 0.01). Gatifloxacin rose (15.2%) (32.7%), remaining high post-COVID-19 (29.7%). A similar trend was observed Streptococcus Corynebacterium, where sharply 12.0% 22.2% 42.9% remained elevated 40.0% 46.4% respectively These findings emphasize rapid rise of fluoroquinolone several groups, underscoring urgent need for continuous surveillance improved stewardship enhance treatment outcomes.

Язык: Английский

Epidemiological and Antimicrobial Resistance Trends in Bacterial Keratitis: A Hospital-Based 10-Year Study (2014–2024) DOI Creative Commons

Qingquan Shi,

Dongyu Mao,

Zijun Zhang

и другие.

Microorganisms, Год журнала: 2025, Номер 13(3), С. 670 - 670

Опубликована: Март 17, 2025

Bacterial keratitis (BK) is a severe ocular infection that can lead to vision loss, with antimicrobial resistance (AMR) posing growing challenge. This study retrospectively analyzed 1071 bacterial isolates from corneal infections over 10-year period (2014–2024) at tertiary ophthalmic center in Beijing, categorizing them into three distinct phases: pre-COVID-19, during COVID-19, and post-COVID-19. The results indicated significant changes pathogen distribution, including marked decrease Gram-positive cocci (from 69.8% pre-COVID-19 49.3% post-COVID-19, p < 0.001), particularly Staphylococcus epidermidis. In contrast, bacilli, Corynebacterium spp., increased 4.2% 16.1% (p 0.001). susceptibility gatifloxacin, moxifloxacin, ciprofloxacin significantly declined both bacilli the COVID-19 (all 0.01). Gatifloxacin rose (15.2%) (32.7%), remaining high post-COVID-19 (29.7%). A similar trend was observed Streptococcus Corynebacterium, where sharply 12.0% 22.2% 42.9% remained elevated 40.0% 46.4% respectively These findings emphasize rapid rise of fluoroquinolone several groups, underscoring urgent need for continuous surveillance improved stewardship enhance treatment outcomes.

Язык: Английский

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