Pharmacological Research,
Год журнала:
2024,
Номер
207, С. 107323 - 107323
Опубликована: Июль 23, 2024
The
natural
aging
process
is
accompanied
by
changes
in
exosomes,
gut
microbiota,
and
metabolites.
This
study
aimed
to
reveal
the
anti-aging
effect
mechanisms
of
fecal
microbiota
transplantation
(FMT)
from
young
donors
on
mice
analyzing
metabolomics.
Aging-relevant
telomeric
length,
oxidative
stress
indexes
brain
tissue,
serum
cytokine
levels
were
measured.
Flow
analysis
T-regulatory
(Treg),
CD4
The Natural Products Journal,
Год журнала:
2024,
Номер
14(8)
Опубликована: Янв. 26, 2024
Abstract:
Various
geographical
areas
exhibit
varying
degrees
of
prevalence
and
severity
dermatological
issues.
The
most
commonly
observed
skin
issues
among
adolescents
during
their
growth
period
on
a
global
scale
encompass
dry
skin,
dyspigmentation,
wrinkles,
fungal
infections,
as
well
benign
malignant
tumors.
These
conditions
arise
consequence
diminished
functional
capacity
heightened
susceptibility.
primary
manifestation
the
whole
process
ageing
is
its
visual
presentation,
which
encompasses
changes
in
both
structure
function
skin.
look
human
particular
variations
individuals
age,
representing
time-dependent
phenomenon.
This
review
article
primarily
examines
discussion
surrounding
diverse
phytoconstituents
impact
signalling
pathways
cellular
metabolism,
interaction
with
environmental
factors
xenobiotic
agents
that
contribute
to
aging.
Ultraviolet
(UV)
light
induces
rapid
formation
subsequent
accumulation
reactive
oxygen
species
(ROS)
within
cells,
hence
accelerating
oxidative
stress
One
effective
approach
addressing
age-related
disorders
entails
utilization
exogenous
supplementation
through
consumption
dietary
antioxidants,
application
antioxidant-based
lotions
prior
sun
exposure.
Several
plant
include
phenolic
components,
including
ascorbic
acid,
ellagitannins,
carotenoids,
have
ability
protect
from
harmful
UV
radiation,
reduce
inflammation
stress,
influence
several
survival
pathways.
comprehensive
study
elucidated
multiple
processes
by
exert
effects
for
intervention
purposes.
Additionally,
it
highlighted
these
modulate
NF-κB
pathway,
MAPK
signalling,
Nrf2
other
pathways,
demonstrating
potential
anti-aging
properties.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 9, 2024
Abstract
Backgroud
Diabetic
kidney
disease
(DKD)
represents
a
microvascular
complication
of
diabetes
mellitus.
Shenkang
Pills
(SKP),
traditional
Chinese
medicine
formula,
has
been
widely
used
in
the
treatment
DKD
and
obvious
antioxidant
effect.
Ferroptosis,
novel
mode
cell
death
due
to
iron
overload,
shown
be
associated
with
DKD.
Nevertheless,
precise
effects
underlying
mechanisms
SKP
on
ferroptosis
diabetic
remain
unclear.
Methods
The
active
components
were
retrieved
from
Traditional
Medicine
Systems
Pharmacology
(TCMSP)
database.Targets
related
collected
GeneCards
database.
Protein-protein
interaction
(PPI)
network
Herb-ingredient-targets
gene
constructed
using
Cytoscape.
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analyses
conducted
utilizing
Metascape
system
Additionally,
an
vivo
model
induced
by
Streptozotocin
(STZ)
was
established
further
investigate
validate
possible
effectiveness
SKP.
Results
We
56
compounds
identified
223
targets
through
TCMSP
Key
PPI.
Using
Herb-ingredient-Targets
network,
primary
ingredients
alleviate
obtained.
KEGG
analysis
suggested
that
potential
HIF
signaling
pathway,
thereby
mitigating
renal
injury
In
animal
experiments,
fasting
blood
glucose,
24h
urine
protein,
urea
nitrogen
serum
creatine
measured.
results
showed
could
improve
experiments
also
confirmed
efficacy
alleviating
fibrosis,
oxidative
stress
mice.These
accompanied
significant
reductions
tissue
expression
HIF-1α
HO-1
proteins.
mRNA
immunohistochemistry
same
as
above.
Conclusions
potentially
subduing
intricacies
HIF-1α/HO-1
pathway.
Abstract
This
study
investigated
the
effects
of
oxidative
stress
on
cell
viability
(MTT
test),
free
radicals
(DCF-DA
test)
induction,
and
metabolomic
profiles.
Hydrogen
peroxide
was
added
to
cultures
human
embryonic
kidney
line
(HEK-293)
African
green
monkey
(COS-7),
resulting
in
changes
both
extracellular
intracellular
metabolites.
Metabolomic
studies
using
nuclear
magnetic
resonance
(NMR)
showed
consistent
metabolites
like
glutamate,
NAD+/NADH,
glutathione,
ATP,
AMP,
pyruvate,
significant
such
as
glutamine,
acetate,
lactate,
linked
mitochondrial
processes.
found
that
COS-7
cells
exhibit
greater
resistance
compared
HEK-293
line.
Pharmacological Research,
Год журнала:
2024,
Номер
207, С. 107323 - 107323
Опубликована: Июль 23, 2024
The
natural
aging
process
is
accompanied
by
changes
in
exosomes,
gut
microbiota,
and
metabolites.
This
study
aimed
to
reveal
the
anti-aging
effect
mechanisms
of
fecal
microbiota
transplantation
(FMT)
from
young
donors
on
mice
analyzing
metabolomics.
Aging-relevant
telomeric
length,
oxidative
stress
indexes
brain
tissue,
serum
cytokine
levels
were
measured.
Flow
analysis
T-regulatory
(Treg),
CD4
