Caspase-9 and p53 Protein Levels in Cancer Patients after Different Anesthesia Techniques DOI Creative Commons

A. O. Soloviev,

В. Т. Долгих,

О. Н. Новичкова

и другие.

General Reanimatology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

The aim of this study was to investigate the changes in caspase-9 and p53 levels as biomarkers pro- anti-apoptotic pathways early postoperative period patients who underwent lung surgery for malignant tumors under different types multimodal or inhalation-intravenous anesthesia. Material Methods. A single-center prospective 22 aged 45-64 years conducted at Omsk Clinical Oncology Early Treatment Prevention Center from January April 2020. participants were divided into two groups. Group 1 received anesthesia, which included sympathetic nerve block prolonged epidural analgesia period. 2 inhalational intravenous anesthesia followed by systemic morphine analgesia. Serum protein measured four time points: before one, twelve, twenty-four hours after surgery. Statistical hypotheses tested using nonparametric (rank) analysis methods. Friedman's ANOVA used compare multiple points, while Wilcoxon test variables between points dependent samples. Mann-Whitney assess differences groups independent P-values < 0.05 considered statistically significant. Results are expressed median ± half interquartile range (Me (LQ-UQ)/2). Results. At point 2, significantly higher group than (P = 0.045). There no significant any other points. Conclusion. lack a difference serum most demonstrates efficacy methods used. Meanwhile, level one hour greater susceptibility without blockade activation apoptotic cell death program.

Язык: Английский

Caspase-9 and p53 Protein Levels in Cancer Patients after Different Anesthesia Techniques DOI Creative Commons

A. O. Soloviev,

В. Т. Долгих,

О. Н. Новичкова

и другие.

General Reanimatology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

The aim of this study was to investigate the changes in caspase-9 and p53 levels as biomarkers pro- anti-apoptotic pathways early postoperative period patients who underwent lung surgery for malignant tumors under different types multimodal or inhalation-intravenous anesthesia. Material Methods. A single-center prospective 22 aged 45-64 years conducted at Omsk Clinical Oncology Early Treatment Prevention Center from January April 2020. participants were divided into two groups. Group 1 received anesthesia, which included sympathetic nerve block prolonged epidural analgesia period. 2 inhalational intravenous anesthesia followed by systemic morphine analgesia. Serum protein measured four time points: before one, twelve, twenty-four hours after surgery. Statistical hypotheses tested using nonparametric (rank) analysis methods. Friedman's ANOVA used compare multiple points, while Wilcoxon test variables between points dependent samples. Mann-Whitney assess differences groups independent P-values < 0.05 considered statistically significant. Results are expressed median ± half interquartile range (Me (LQ-UQ)/2). Results. At point 2, significantly higher group than (P = 0.045). There no significant any other points. Conclusion. lack a difference serum most demonstrates efficacy methods used. Meanwhile, level one hour greater susceptibility without blockade activation apoptotic cell death program.

Язык: Английский

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