Mechanisms and functions of lysosomal lipid homeostasis
Cell chemical biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Lysosome targeted therapies in hematological malignancies
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 24, 2025
Lysosomes
are
dynamic
organelles
integral
to
cellular
homeostasis,
secretory
pathways,
immune
responses,
and
cell
death
regulation.
In
cancers,
lysosomes
become
dysregulated
sustain
proliferative
signaling,
metabolism,
invasion.
hematological
malignancies
such
as
acute
myeloid
leukemia
(AML),
lymphoblastic
(ALL),
chronic
(CML),
lymphocytic
(CLL),
cells
demonstrate
lysosome
dysregulation
with
increased
lysosomal
activity,
mTORC1
catabolic
reactions,
autophagy.
This
supports
the
survival,
proliferation
of
cells.
also
play
a
critical
role
in
treatment
resistance
by
promoting
survival
sequestration
drugs.
has
led
development
lysosome-targeted
therapies
cationic
amphiphilic
drugs
(CAD),
ATPase
inhibitors
or
autophagy
treat
malignancies.
Lysosome-targeted
treatments
have
shown
effectiveness
at
inducing
inhibiting
mechanisms
apoptosis.
addition,
combination
standard
gives
synergistic
apoptotic
responses
this
review,
we
will
describe
functions,
their
targeted
for
treatment.
By
understanding
developing
agents,
innovative
strategies
could
be
effective
overcoming
drug
Язык: Английский
Alzheimer’s, Parkinson’s, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine
Toxics,
Год журнала:
2025,
Номер
13(3), С. 178 - 178
Опубликована: Фев. 28, 2025
Billions
of
people
are
exposed
to
fine
particulate
matter
(PM2.5)
levels
above
the
USEPA’s
annual
standard
9
μg/m3.
Common
emission
sources
anthropogenic,
producing
complex
aerosolized
toxins.
Ultrafine
(UFPM)
and
industrial
nanoparticles
(NPs)
have
major
detrimental
effects
on
brain,
but
USA
does
not
measure
UFPM
a
routine
basis.
This
review
focuses
development
progression
common
neurodegenerative
diseases,
as
diagnosed
through
neuropathology,
among
young
residents
in
Metropolitan
Mexico
City
(MMC).
MMC
is
one
most
polluted
megacities
world,
with
population
22
million
residents,
many
whom
unaware
brain
caused
by
their
atmosphere.
Fatal
diseases
(such
Alzheimer’s
Parkinson’s)
that
begin
childhood
populations
living
air
environments
preventable.
We
conclude
UFPM/NPs
capable
disrupting
neural
homeostasis
give
rise
relentless
processes
throughout
entire
life
highly
MMC.
The
paradigm
reaching
old
age
neurodegeneration
no
longer
supported.
Neurodegenerative
changes
start
early
pediatric
ages
irreversible.
It
time
invest
preventive
medicine.
Язык: Английский
The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease
Biomolecules,
Год журнала:
2025,
Номер
15(4), С. 525 - 525
Опубликована: Апрель 3, 2025
The
vacuolar-type
ATPase
(V-ATPase)
is
a
multi-subunit
enzyme
complex
that
maintains
lysosomal
acidification,
critical
process
for
cellular
homeostasis.
By
controlling
the
pH
within
lysosomes,
V-ATPase
contributes
to
overall
homeostasis,
helping
maintain
balance
between
degradation
and
synthesis
of
components.
Dysfunction
impairs
leading
accumulation
undigested
materials
contributing
various
diseases,
including
cardiovascular
diseases
(CVDs)
like
atherosclerosis
myocardial
disease.
Furthermore,
V-ATPase's
role
in
function
suggests
potential
therapeutic
strategies
targeting
this
mitigate
disease
progression.
Understanding
mechanisms
by
which
influences
pathology
essential
developing
novel
treatments
aimed
at
improving
outcomes
patients
with
heart
vascular
diseases.
Язык: Английский