Cancers, Год журнала: 2024, Номер 16(23), С. 4095 - 4095
Опубликована: Дек. 6, 2024
Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal cancers, marked by rapid progression, pronounced chemoresistance, and a complex network genetic epigenetic dysregulation. Within this challenging context, sirtuins, NAD
Язык: Английский
International Journal of Food Properties, Год журнала: 2023, Номер 26(1), С. 2294 - 2337
Опубликована: Авг. 20, 2023
Honey, propolis, and passionflower contain a flavone known as chrysin. Researchers are studying chrysin to prove its potential stop cancer cells growth. Chrysin therapeutic is of great interest numerous studies have been done illustrate this potential. It associated protein pathways effectively suppress tumor growth within the body. shown ability kill breast, prostate, lung, liver, stomach cancerous cells. can block Phosphoinositide 3-kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) Mitogen-activated kinase/extracellular signal-regulated (MAPK/ERK) signaling in different animals against various cancers. has breast laboratory setting by inhibiting their cell division. strongly suppresses Matrix metalloproteinase-9 (MMP-9), Urokinase plasminogen activator (uPA) Vascular endothelial factor (VEGF), i.e. factors that cause cancer. androgen receptor (AR), necessary for prostate development metastasis. starts caspase cascade blocks synthesis lung Unnecessary apoptosis be prevented stopping certain pathways. significantly decreased metastasis animal-modeled studies. induces stops colon G2/M cycle phase. cancer-promoting cyclin B1 cyclin-dependent 2. suppressed CDK2 production order prevents spread blocking blood vessel expansion. Chrysin's solubility, accessibility bioavailability may limit medical use. targets cancer-related communication present reduce chances onset cancer, it also serve an alternative treatment whole prevent treat cancers, but more clinical trials research needed fully unlock
Язык: Английский
Процитировано
16
Discover Oncology, Год журнала: 2025, Номер 16(1)
Опубликована: Фев. 1, 2025
Pancreatic cancer is an extremely deadly illness for which there are few reliable treatments. Recent research indicates that malignant tumors highly variable and consist of a tiny subset unique cells, known as stem cells (CSCs), responsible the beginning spread tumors. These typically identified by expression specific cell surface markers. A population pancreatic with aberrantly active developmental signaling pathways has been in recent studies human Among these Notch pathway key regulator CSCs self-renewal, making it attractive target therapeutic intervention. Chrysin-loaded polylactic acid (PLA) polymeric nanoparticles systems have growing interest using platforms improved drug delivery. This review aims to explore innovative strategies targeted therapy optimized delivery manipulating leveraging PLA-based systems. Furthermore, we will assess capability PLA enhance bioavailability effectiveness gemcitabine cells. The insights gained from this potential contribute development novel treatment approaches combine advanced utilizing biodegradable nanoparticles.
Язык: Английский
Процитировано
0
Journal of Genetic Engineering and Biotechnology, Год журнала: 2025, Номер 23(1), С. 100464 - 100464
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
0
BMC Research Notes, Год журнала: 2025, Номер 18(1)
Опубликована: Фев. 12, 2025
Abstract Background Hypoxia is a common symptom of lung cancer. Proliferation and neovascularization mediated by hypoxia-inducible factors (HIF) influence several adaptations. It has recently been established that naringenin (NAR) its nanoparticles are chemo-preventive flavonoids in Aim Adjust HIF activity reviving oxygen-sensing enzyme while considering possible therapeutic targets. Method The bindings NAR to target proteins were examined using computational modeling techniques. Additionally, (NARNPs) synthesized characterized. Normal fibroblast cells A549 used determine cytotoxicity. Colorimetric analysis α-ketoglutarate detection for hydroxylases. Results According molecular modeling, have high affinity. PHD FIH activities significantly stimulated. Conclusion NARNPs diminish hypoxia cancer stimulating
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2024, Номер 17(4), С. 515 - 515
Опубликована: Апрель 17, 2024
The natural flavonoid compound chrysin has promising anti-tumor effects. In this study, we aimed to investigate the mechanism by which inhibits growth of non-small cell lung cancer (NSCLC). Through in vitro culture and animal models, explored impact on NSCLC cells pro-cancer effects tumor-associated macrophages (TAMs) their mechanisms. We observed that M2-TAMs significantly promoted migration cells, while also markedly activating autophagy level these cells. Chrysin displayed a significant inhibitory effect it could suppress inhibit mediated autophagy. Furthermore, combining network pharmacology, found inhibited TAMs-mediated activation through regulation CDK1/ULK1 signaling pathway, rather than classical mTOR/ULK1 pathway. Our study reveals novel thereby suppressing growth. This discovery not only provides new therapeutic strategies for but opens up avenues further research chrysin.
Язык: Английский
Процитировано
2
Medical Radiology and radiation safety, Год журнала: 2024, Номер 69(1), С. 28 - 32
Опубликована: Фев. 1, 2024
Relevance: A number of researchers consider the study radioprotective properties non-toxic or low-toxic natural substances to be a promising direction. special place among them is occupied by antioxidants and participants in basic reactions metabolism. In order avoid methodological errors when performing these studies, it necessary conduct additional experiments. For example, various on cell cultures using tablet readers, first make sure that do not affect ability cells adsorb bottom wells interfere with proliferation. And if such an influence detected, further experiments should planned taking into account information received. Purpose: To search effect ascorbic, malic succinic acids lung adenocarcinoma (A549) adhere 96-well plate, followed onset proliferation fluorescence registration method Hoechst-33342 fluorophore. Methodology: The experiment was carried out tablet. working concentration 1 μg/ml (1.62 μM). Fluorescence recorded at wavelength 460 nm samples were excited light 355 nm. ascorbate, malate succinate adhesion proliferation, 20,000 solution one 2 mM introduced estimated based after day incubation. Result: containing acid ascorbic acid, statistically significant decrease intensity observed compared sample did contain drug. This suggests compounds negatively growth A549 culture: they inhibit slow down their Scope results conclusions:The obtained are for methodologically correct planning most detailed studies line model fluorescent methods, including under rare ionizing neutron radiation.
Язык: Английский
Процитировано
1
Genes & Nutrition, Год журнала: 2024, Номер 19(1)
Опубликована: Май 27, 2024
Mitochondrial respiration complexes play a crucial function. As result, dysfunction or change is intimately associated with many different diseases, among them cancer. The epigenetic, evolutionary, and metabolic effects of mitochondrial complex IΙ are the primary concerns our review. Provides novel insight into vital role naringenin (NAR) as an intriguing flavonoid phytochemical in cancer treatment. NAR significant that member flavanone group polyphenols mostly present citrus fruits, such grapefruits, well other fruits vegetables, like tomatoes cherries, foods produced from medicinal herbs. evidence now available indicates NAR, herbal remedy, has pharmacological qualities anti-cancer effects. Through variety mechanisms, including induction apoptosis, cell cycle arrest, restriction angiogenesis, modulation several signaling pathways, prevents growth However, hydrophobic crystalline structure primarily responsible for its instability, limited oral bioavailability, water solubility. Furthermore, there no targeting high rate breakdown acidic environment. These shortcomings barriers to efficient medical application. Improvement ΙΙ by loading it on chitosan nanoparticles promising strategy.
Язык: Английский
Процитировано
1
Heliyon, Год журнала: 2024, Номер 10(15), С. e34442 - e34442
Опубликована: Июль 10, 2024
This study summarizes and analyzes the relationship between mitochondria pathogenesis of lung cancer. The related articles in Web Science core literature database are searched collected, data processed by R software, Citespace, VOSviewer, Excel. A total 4476 papers were retrieved, from 20162 co-authors 3968 institutions 84 countries published 951 journals. Through various bibliometric analysis tools, cancer was analyzed, previous research results summarized, potential direction found.
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 16, 2024
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2024, Номер 16(23), С. 4095 - 4095
Опубликована: Дек. 6, 2024
Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal cancers, marked by rapid progression, pronounced chemoresistance, and a complex network genetic epigenetic dysregulation. Within this challenging context, sirtuins, NAD
Язык: Английский
Процитировано
0