Effects of TABATA Exercise Volume and Royal Jelly Supplementation on NLRP3 Inflammasome and lncRNA-H19 Expression in Obese Men DOI Open Access
Samira Gholitabar, Valiollah Dabidi Roshan, Masoumeh Fallah

и другие.

Asian Journal of Sports Medicine, Год журнала: 2024, Номер In Press(In Press)

Опубликована: Ноя. 11, 2024

Background: Both coding and long non-coding RNAs (lncRNAs) have emerged as vital regulators in almost every cellular process, their expression can be modulated by external stimuli, such physical exercise. Objectives: The current research aimed to investigate the effects of different volumes TABATA-high-intensity interval training (HIIT) exercises combined with royal jelly (RJ) supplementation on NLRP3 inflammasome lncRNA-H19 obese males. Methods: Forty-two healthy men [Body Mass Index (BMI) = 30 kg/m², waist-to-hip ratio 0.95, age range: 40 - 60 years] volunteered participate study. individuals were randomly divided into five experimental groups (N 35) one control + placebo group 7). high-volume (HV) or low-volume (LV) TABATA exercise programs performed twice a week for 8 weeks. Participants RJ received 1000 mg capsule once day genes was evaluated using real-time PCR method. Results: gene Bruce test, measured before after 8-week interventions supplementation, showed insignificant changes across groups. However, H19 test significant reduction HV-TABATA HIIT intervention groups, which more pronounced than LV weeks: HV (P 0.004), 0.001), 0.007), 0.002). After weeks non-pharmacological involving decrease increase detected compared 0.05 P 0.010). Significant improvement also found resting levels between 0.011) 0.44). Moreover, observed 0.038). Conclusions: Chronic exercise, when is effective attenuating inflammatory responses acute stress.

Язык: Английский

Elucidating the Mechanisms of Acquired Palbociclib Resistance via Comprehensive Metabolomics Profiling DOI Creative Commons
Lulu Yang, Yajun Yue, Zhendong Wang

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(1), С. 24 - 24

Опубликована: Янв. 2, 2025

Palbociclib is a cyclin-dependent kinase 4/6 inhibitor and commonly used antitumor drug. Many cancers are susceptible to palbociclib resistance, however, the underlying metabolism mechanism extent of resistance unknown. In this study, LC-MS metabolomics was investigate metabolite changes colorectal cancer SW620 cells that were resistant palbociclib. The study indicated there 76 expression differences between with parental involving amino acids, glutathione, ABC transporters, so on. MetaboAnalyst 6.0 metabolic pathway analysis showed arginine synthesis, β-alanine metabolism, purine disrupted. These results may provide potential clues drug in Our has contribute anti-palbociclib resistance.

Язык: Английский

Процитировано

0
Vitamin D: What role in obesity-related cancer? DOI
Pierrick Martinez, William B. Grant

Seminars in Cancer Biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Effects of TABATA Exercise Volume and Royal Jelly Supplementation on NLRP3 Inflammasome and lncRNA-H19 Expression in Obese Men DOI Open Access
Samira Gholitabar, Valiollah Dabidi Roshan, Masoumeh Fallah

и другие.

Asian Journal of Sports Medicine, Год журнала: 2024, Номер In Press(In Press)

Опубликована: Ноя. 11, 2024

Background: Both coding and long non-coding RNAs (lncRNAs) have emerged as vital regulators in almost every cellular process, their expression can be modulated by external stimuli, such physical exercise. Objectives: The current research aimed to investigate the effects of different volumes TABATA-high-intensity interval training (HIIT) exercises combined with royal jelly (RJ) supplementation on NLRP3 inflammasome lncRNA-H19 obese males. Methods: Forty-two healthy men [Body Mass Index (BMI) = 30 kg/m², waist-to-hip ratio 0.95, age range: 40 - 60 years] volunteered participate study. individuals were randomly divided into five experimental groups (N 35) one control + placebo group 7). high-volume (HV) or low-volume (LV) TABATA exercise programs performed twice a week for 8 weeks. Participants RJ received 1000 mg capsule once day genes was evaluated using real-time PCR method. Results: gene Bruce test, measured before after 8-week interventions supplementation, showed insignificant changes across groups. However, H19 test significant reduction HV-TABATA HIIT intervention groups, which more pronounced than LV weeks: HV (P 0.004), 0.001), 0.007), 0.002). After weeks non-pharmacological involving decrease increase detected compared 0.05 P 0.010). Significant improvement also found resting levels between 0.011) 0.44). Moreover, observed 0.038). Conclusions: Chronic exercise, when is effective attenuating inflammatory responses acute stress.

Язык: Английский

Процитировано

0