Pharmaceuticals in a Mediterranean Basin: The influence of temporal and hydrological patterns in environmental risk assessment

The Science of The Total Environment, Год журнала: 2019, Номер 709, С. 136205 - 136205

Опубликована: Дек. 18, 2019

Язык: Английский

---

Environmental DNA Shaping a New Era of Ecotoxicological Research

Environmental Science & Technology, Год журнала: 2019, Номер 53(10), С. 5605 - 5612

Опубликована: Апрель 22, 2019

Aquatic ecosystems, such as rivers and lakes, are exposed to multiple stressors from anthropogenic activity changes in climate, which have resulted a general decrease biodiversity, alteration of community structures, can ultimately result reduction resources provided by natural ecosystems. Adverse outcomes caused pollutants ecosystems determined not only toxic properties but also ecological contexts including indigenous biodiversity composition. It is therefore important identify key factors, diversity species traits that determine the vulnerability structures functions response substances. Detection quantification its activities using environmental DNA (eDNA) arguably one most technical advances ecology recent years. A huge opportunity has appeared allow more relevant approaches for assessments risks posed eDNA provide effective efficient tools evaluate effects chemical on (1) occurrences population wildlife, (2) communities, (3) function ecosystem field. Here conceptual framework adverse outcome pathways relate molecular initiating events apical ecosystem-level responses proposed connecting laboratory-based prediction observations under field conditions. Particularly, future research opportunities structure, substances will be discussed.

Язык: Английский

---

Comparative evaluation of river chemical status based on WFD methodology and CCME water quality index

The Science of The Total Environment, Год журнала: 2020, Номер 745, С. 140849 - 140849

Опубликована: Июль 15, 2020

Язык: Английский

---

A review of modeling pesticides in freshwaters: Current status, progress achieved and desirable improvements.

Environmental Pollution, Год журнала: 2022, Номер 316, С. 120553 - 120553

Опубликована: Ноя. 5, 2022

This study comprises a critical review of modeling pesticides in surface waters. The aim was to update the status use models simulate fate from diffuse sources. ISI papers were selected on Scopus and information concerning areas, type (herbicides, fungicides insecticides), model, methodology adopted (i.e., calibration and/or validation, spatial temporal scales) analyzed. studies carried out Europe (55.5%), North America (22.3%), Asia (13.9%) South (8.3%). Soil Water Assessment Tool proved be most used model (45.95%). Herbicides modeled (71.4%), followed by insecticides (18.2%) (10.4%). main herbicides atrazine, metolachlor, isoproturon, glyphosate, acetochlor. Insecticides such as chlorpyrifos metaldehyde. Chlorothalonil, tebuconazole) widely investigated. Based published studies, it found that approaches for assessing are constantly evolving algorithms work well with diverse watershed conditions, management strategies, pesticide properties. Several reported concentrations exceeding ecotoxicological thresholds revealing water contamination agriculture urban areas is priority issue current global concern.

Язык: Английский

---

Behavioral profile alterations in zebrafish larvae exposed to environmentally relevant concentrations of eight priority pharmaceuticals

The Science of The Total Environment, Год журнала: 2019, Номер 664, С. 89 - 98

Опубликована: Янв. 25, 2019

Язык: Английский

---

Prioritising site-specific micropollutants in surface water from LC-HRMS non-target screening data using a rarity score

Environmental Sciences Europe, Год журнала: 2019, Номер 31(1)

Опубликована: Июль 22, 2019

Current compound prioritisation and monitoring approaches within Europe focus mainly on widely occurring priority river basin specific pollutants but may overlook site-specific contamination from local emission sources. Thus, we propose a robust semiautomated approach for the identification of chemicals water bodies with based non-target screening data liquid chromatography coupled to high-resolution mass spectrometry. For contaminants, calculated rarity scores all peaks in set 31 surface samples, which combine maximum signal intensity peak dataset its frequency occurrence that one single number. These were measure without need address problems missing more sophisticated multivariate statistical methods. our dataset, compounds defined > 1000, studied sites showed huge difference number such (0–91 positive 0–48 negative ion mode). Together isotopologue detection, evaluation defects homologue series, could be obtained automated processing, detailed characterisation these contaminations was possible. three selected high peaks, novel or unexpected identified, stem usage (former) industrial production upstream sites. The proposed allows rapid large datasets subsequent compounds. risk overlooking possibly hazardous (including unknowns) are not covered conventional schemes is reduced.

Язык: Английский

---

Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge

Environmental Science & Technology, Год журнала: 2021, Номер 55(10), С. 6729 - 6739

Опубликована: Апрель 28, 2021

Diverse organic compounds, many derived from consumer products, are found in sewage sludge worldwide. Understanding which of these poses the most significant environmental threat following land application can be investigated through a variety predictive and cell-based toxicological techniques. Nontargeted analysis using high-resolution mass spectrometry with estrogenic activity modeling was performed on samples 12 wastewater treatment plants California. Diisobutyl phthalate dextrorphan were predicted to exhibit identified >75% samples, signifying their universal presence persistence. Additionally, an estrogen-responsive cell bioassay revealed reductions agonistic during mesophilic thermophilic but increases antagonism treatment, warrants further research. Ten nontarget features (metoprolol, fenofibric acid, erythrohydrobupropion, oleic mestranol, 4'-chlorobiphenyl-2,3-diol, medrysone, scillarenin, sudan I, N,O-didesmethyltramadol) set considered have influenced vitro observed. The combination estrogenicity nontargeted has led confirmation estrogen-active contaminants California highlighted importance evaluating both antagonistic responses when bioactivity complex samples.

Язык: Английский

---

Characterization of different contaminants and current knowledge for defining chemical mixtures in human milk: A review

Environment International, Год журнала: 2022, Номер 171, С. 107717 - 107717

Опубликована: Дек. 22, 2022

Hundreds of xenobiotics, with very diverse origins, have been detected in human milk, including contaminants emerging concern, personal care products and other current-use substances reflecting lifestyle. The routes exposure to these chemicals include dermal absorption, ingestion inhalation. Specific families are dominant among milk monitoring studies (e.g., organochlorine pesticides, bisphenol A, dioxins), even though understudied may be equally toxicologically relevant food-processing chemicals, plasticizers flame retardants, mycotoxins). Importantly, the lack reliable data for some individual and, especially, complex mixtures, is a major factor hindering risk assessment. Non-targeted screening can used as an effective tool identify unknown concern milk. This approach, combination novel methods conduct assessments on chemical mixtures will assist elucidating exposures that adverse effects development breastfeeding infants.

Язык: Английский

---

Large-scale assessment of organic contaminant emissions from chemical and pharmaceutical manufacturing into Swiss surface waters

Water Research, Год журнала: 2022, Номер 215, С. 118221 - 118221

Опубликована: Фев. 23, 2022

This study presents a nation-wide assessment of the influence chemical and pharmaceutical manufacturing (CPM) wastewaters on synthetic organic contaminant (SOC) emissions to Swiss surface waters. Geographic Information System (GIS) based analysis presence CPM in wastewater treatment plant (WWTP) catchments revealed wide distribution this industrial sector across Switzerland, suggesting that one-third 718 WWTPs may be influenced by wastewaters. To reflect diversity type wastewaters, we investigated effluents 11 diverse sizes technologies, which treated 0-100% from variety activities. In an extensive sampling campaign, collected temporally high resolved (i.e., daily) samples for 2-3 months capture dynamics discharges. The > 850 were then measured with liquid chromatography high-resolution mass spectrometry (LC-HRMS). Non-target characterization LC-HRMS time series datasets left highly variable site-specific signature WWTPs. Particularly, compared purely domestic input, larger substances (up 15 times more compounds) higher maximum concentrations (1-2 orders magnitude) uncommon found CPM-influenced effluents. Moreover, latter, fluctuating discharges often contributed substantial fraction overall emissions. largely varying characteristics between different facilities primarily related activities at industries production versus processing chemicals) as well pre-treatment storage Eventually, one WWTP, correlated ecotoxicity obtained bioassays major toxic components could identified. Overall, view their potential relevance water quality, strong focus SOC is essential, including design situation-specific monitoring, risk mitigation strategies consider variability

Язык: Английский

---

The EU Horizon 2020 project GRACE: integrated oil spill response actions and environmental effects

Environmental Sciences Europe, Год журнала: 2019, Номер 31(1)

Опубликована: Июль 16, 2019

This article introduces the EU Horizon 2020 research project GRACE (Integrated oil spill response actions and environmental effects), which focuses on a holistic approach towards investigating understanding hazardous impact of spills impacts benefits suite marine technologies in cold climate ice-infested areas North Atlantic Baltic Sea. The methods considered include mechanical collection water below ice, situ burning, use chemical dispersants, natural biodegradation, combinations these. naturally chemically dispersed oil, residues resulting from non-collected fish, invertebrates (e.g. mussels, crustaceans) macro-algae are assessed by using highly sensitive biomarker methods, specific for rapid detection effects pollution biota developed. By observing, monitoring predicting movements sea through novel online sensors vessels, fixed platforms including gliders so-called SmartBuoys together with real-time data transfer into operational systems that help to improve information location spill, situational awareness can be improved. Methods findings integrated strategic net benefit analysis tool (environment response, EOS) strategy decision making climates areas.

Язык: Английский

---