Systematic Review of the Effects of Exercise and Physical Activity on the Gut Microbiome of Older Adults

Nutrients, Год журнала: 2022, Номер 14(3), С. 674 - 674

Опубликована: Фев. 5, 2022

Recent evidence suggests that exercise/physical activity (PA) can beneficially alter the gut microbiome composition of young people, but little is known about its effects in older adults. The aim this systematic review was to summarize results human studies have assessed effects/associations PA/exercise on adults and better understand whether help promote healthy ageing. Seven were included overall, exercise increased amounts PA associated with decreases abundance several well-known harmful taxa increases health-promoting taxa. Altogether, findings from suggest exercise/PA a beneficial impact health by improving composition. However, due methodological sampling disparities, it not possible reach consensus which most affected or PA.

Язык: Английский

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Impact of aging on the pathophysiology of dry eye disease: A systematic review and meta-analysis

The Ocular Surface, Год журнала: 2022, Номер 25, С. 108 - 118

Опубликована: Июнь 23, 2022

Язык: Английский

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Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13338 - 13338

Опубликована: Авг. 28, 2023

The human microbiota refers to a large variety of microorganisms (bacteria, viruses, and fungi) that live in different body sites, including the gut, oral cavity, skin, eyes. In particular, presence an ocular surface with crucial role maintaining homeostasis by preventing colonization from pathogen species has been recently demonstrated. Moreover, recent studies underline potential association between gut (GM) health. this respect, some evidence supports existence gut-eye axis involved pathogenesis several diseases, age-related macular degeneration, uveitis, diabetic retinopathy, dry eye, glaucoma. Therefore, understanding link GM these disorders might be useful for development new therapeutic approaches, such as probiotics, prebiotics, symbiotics, or faecal transplantation through which could modulated, thus allowing better management diseases.

Язык: Английский

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TFOS Lifestyle: Impact of nutrition on the ocular surface

The Ocular Surface, Год журнала: 2023, Номер 29, С. 226 - 271

Опубликована: Апрель 25, 2023

Язык: Английский

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Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 1166 - 1166

Опубликована: Янв. 6, 2023

The rate at which obesity is becoming an epidemic in many countries alarming. Obese individuals have a high risk of developing elevated intraocular pressure and glaucoma. Additionally, glaucoma disease proportions. It characterized by neurodegeneration neuroinflammation with optic neuropathy the death retinal ganglion cells (RGC). On other hand, there growing interest microbiome dysbiosis, particularly gut, has been widely acknowledged to play prominent role etiology metabolic illnesses such as obesity. Recently, studies begun highlight fact that dysbiosis could critical onset progression several neurodegenerative diseases, well development ocular disorders. In obese individuals, gut can induce endotoxemia systemic inflammation causing intestinal barrier malfunction. As result, bacteria their metabolites be delivered via bloodstream or mesenteric lymphatic vessels regions level retina nerve, tissue degeneration neuroinflammation. Nowadays, preliminary evidence for existence brain microbiomes. altered perturb resident brain–ocular ecosystem which, turn, exacerbate local inflammation. All these processes, finally, lead RGC neurodegeneration. purpose this literature review explore recent on related common mechanisms underlying

Язык: Английский

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Gut microbiota and derived metabolomic profiling in glaucoma with progressive neurodegeneration

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Авг. 12, 2022

Glaucoma is a multifactorial, neurodegenerative disorder characterized by the loss of retinal ganglion cells (RGCs). Crosstalk between gut microbiota and host involved in progression many diseases, although little known about its role glaucoma. To investigated alterations derived metabolites glaucomatous rats, interaction with RGCs, we performed 16S rRNA (V1-V9) sequencing untargeted metabolomic analyses. The microbial composition differed significantly two groups, diversity cecal bacteria was dramatically reduced rats. Firmicutes/Bacteroidetes (F/B) ratio, Verrucomicrobia phylum, some bacterial genera (Romboutsia, Akkermansia, Bacteroides) were increased rat model compared control, which showed negative correlation RGCs. Untargeted analysis identified 284 differentially expressed metabolites, Kyoto Encyclopedia Genes Genomes pathway enrichment revealed considerable mainly bile secretion pathways. relationships among enriched pathway, microbiota, RGCs investigated, glutathione (GSH) found to be negatively correlated Bacteroides F/B positively Reduced GSH level blood glaucoma rats further established, Romboutsia ratio This finding suggests potential glaucoma, GSH, major antioxidant metabolite, related their effects, indicating for development microbiota-targeted interventions

Язык: Английский

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The mediating role of gut microbiota in the associations of prenatal maternal combined exposure to lead and stress with neurodevelopmental deficits in young rats.

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 255, С. 114798 - 114798

Опубликована: Март 20, 2023

Prenatal single and combined exposure to lead (Pb) stress (Ps) impairs neurodevelopment. Pb or Ps affects the composition of intestinal microbiota, bidirectional communication between gut microbiota central nervous system has been well recognized. However, whether mediated effects prenatal Pb+Ps co-exposure on neurodevelopmental deficits remains unclear. This study established rat models with Pb. We investigated such hippocampal structures using morphological analyses, learning/memory Morris-water-maze test, fecal 16S rRNA sequencing. The mediating roles were analyzed bootstrap method. found both affected ultra-structures spatial learning/memory, most significant impairments observed in group. decreased microbial alpha/beta-diversity. Significantly lower levels B/F-ratio, class-Bacteroidia, order-Bacteroidales, family-S24-7, significantly higher class-Bacilli, order-Lactobacillales, family-Lactobacillaceae, genus-Lactobacillus group, compared controls. Increased relative abundances genus-Helicobacter detrimental effect Ps+Pb [β (95%CI) for total indirect effects: - 10.70 (-19.19, -2.21) 4.65(-11.07, -1.85)], accounting 43.47% effect. As a result, increased alleviated adverse alleviation accounted 44.55% direct 0.28(-0.48, -0.08) 0.13(0.01, 0.41)]. suggested that induced more offspring neurodevelopment than exposure, alterations microbiome may mediate developmental neurotoxicity by co-exposure.

Язык: Английский

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Multi-cohort analysis identifying core ocular surface microbiome and bacterial alterations in eye diseases

Eye, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Язык: Английский

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Potential Risks of Ocular Molecular and Cellular Changes in Spaceflight

Seminars in Ophthalmology, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Март 17, 2025

Purpose Many fundamental cellular and molecular changes are known to occur in biological systems during spaceflight, including oxidative stress, DNA damage, mitochondrial epigenetic factors, telomere lengthening, microbial shifts. We can apply the consequences of these ocular cells, such as retinal ganglion cells corneal epithelium, identify ophthalmologic risks spaceflight. This review aims discuss potential greater detail principles ophthalmic disease risk astronauts.

Язык: Английский

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The Gut–Eye Axis: Correlation Between the Gut Microbiota and Autoimmune Dry Eye in Individuals With Sjögren Syndrome

Eye & Contact Lens Science & Clinical Practice, Год журнала: 2022, Номер 49(1), С. 1 - 7

Опубликована: Ноя. 11, 2022

Abstract: The impact of gut microbiota on human health, autoimmunity, and disease occurrence has long been recognized since the advancement metagenomic sequencing technology enabled a new level perspective microbiome. Emerging findings also suggest existence gut–eye axis, wherein dysbiosis may be crucial factor affecting onset progression multiple ocular diseases. Sjögren syndrome (SS) is chronic autoimmune mainly exocrine glands, primarily lacrimal gland in eye, resulting severe dry eye. Although there are currently various treatments for environmental efficacy SS-related eye limited, more effective therapies still need to explored. latest studies have demonstrated that plays key role pathogenesis This review describes effect surface eye; introduces presumable pathways forming “gut dysbiosis–ocular surface–lacrimal axis”; discusses advantages restoring intestinal microecology treat by fecal transplantation or probiotics, which expected provide perspectives into correlation between microbiome enhance our understanding useful development future interventions regulating microbiota.

Язык: Английский

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