Management of Metabolic-Associated Fatty Liver Disease/Metabolic Dysfunction-Associated Steatotic Liver Disease: From Medication Therapy to Nutritional Interventions

Nutrients, Год журнала: 2024, Номер 16(14), С. 2220 - 2220

Опубликована: Июль 11, 2024

Non-alcoholic fatty liver disease (NAFLD) is a common long-lasting that affects millions of people around the world. It best identified with hepatic fat build-up ultimately leads to inflammation and damage. The classification nomenclature NAFLD have long been controversial topic, until 2020 when group international experts recommended substituting MAFLD (metabolic dysfunction-associated FLD). was then terminologically complemented in 2023 by altering it MASLD, i.e., metabolic steatotic (MASLD). Both MASLD terminologies comprise element disorder, as they offer diagnostic benchmarks are embedded risk factors underlie disease. (as multisystemic disease) provides comprehensive definition includes larger population patients who at morbidity mortality, well adverse cardiovascular diabetes outcomes. highlights risks lean or normal weight individuals, factor has not accentuated discussed previous guidelines. Novel antihyperglycemic agents, anti-hyperlipidemic drugs, lifestyle modifications, nutritional interventions, exercise therapies extensively studied MASLD. Nutrition plays vital role managing both conditions, where centralizing on diet rich whole vegetables, fruits, foods, healthy fats, proteins, specific nutrients (e.g., omega-3 acids fibers) can improve insulin resistance reduce inflammation. Thus, essential understand nutrition these conditions work develop an individualized plan for optimal health. This review discusses prevention strategies NAFLD/MAFLD/MASLD management, particular attention correction.

Язык: Английский

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A cross-sectional study of risk factors associated with sarcopenia in patients with metabolic dysfunction-associated steatotic liver disease

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 18, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic linked to several adverse health consequences that include metabolic disturbances affecting skeletal muscle. Sarcopenia, characterized by muscle loss, commonly observed in individuals with MASLD. Our study aimed identify modifiable lifestyle factors associated sarcopenia patients This was cross-sectional conducted three clinics Nablus. A total of 162 adults diagnosed MASLD were recruited for the study. The interviewed and instructed provide necessary information, such as sociodemographic factors, medical surgical history, MASLD-related data, nutritional functional status. Sarcopenia defined using Foundation National Institutes Health (FNIH) criteria, which includes weight-adjusted index (wSMI) cut-off scores (male subjects: 35.7% female 30.7%). Statistical analysis SPSS v.21. chi-squared or independent samples t-test utilized sample. data found 44% had sarcopenia. condition significantly gender (p < 0.0001), older age presence diseases 0.035), medication use 0.05). Regarding significant association obesity, higher body fat percentage, high waist-to-hip ratio, low mid-upper arm circumference, reduced calf circumference 0.001). Sarcopenic often exhibit handgrip strength. Lifestyle history smoking type be positively 0.0001). prevalent population risk can managed reduce its progression. Future research different designs, longitudinal design, recommended determinants Intervention studies are also required improve status patients.

Язык: Английский

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Relationship between phase angle measured with bioelectrical impedance analysis and nonalcoholic fatty liver disease in adults

Nutrition & Food Science, Год журнала: 2024, Номер 54(8), С. 1487 - 1497

Опубликована: Авг. 5, 2024

Purpose The phase angle (PhA) measured by bioelectrical impedance analysis (BIA) is associated with nutritional status and cellular health, it a clinically important parameter used to assess the risk of various diseases. It remains unclear whether PhA nonalcoholic fatty liver. purpose this study investigate relationship between BIA liver disease (NAFLD). Design/methodology/approach This cross-sectional was conducted 300 adults aged 20–64 years (NAFLD: 196, normal: 104). Some biochemical findings participants were collected, whole-body segmental PhAs using Tanita (MC-780) at 50 kHz. Findings values whole body ( p = 0.003), trunk < 0.001), right left legs 0.001 for both) found significantly differ according degrees observed that highest in normal individuals. Logistic regression showed reduction 0.038), 0.019) 0.049) 0.001) after adjusting all confounding factors increased NAFLD. Additionally, age (year, 0.02), BMI (kg/m 2 ; fat mass (kg; (%; albumin (g/L; CRP (mg/dL; 0.001). Originality/value results can be management To identify potential mechanisms NAFLD, large-scale prospective studies are needed.

Язык: Английский

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Linking Depression, Non-Alcoholic Fatty Liver Disease, and Sarcopenia

Springer eBooks, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Янв. 1, 2024

Язык: Английский

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Association of dietary inflammatory index with sarcopenia in patients with Metabolic dysfunction-associated fatty liver disease: a cross-sectional study

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Ноя. 8, 2024

Sarcopenia is a common complication of fatty liver, and sarcopenia increases the risk advanced liver fibrosis in patients with Metabolic dysfunction-associated disease (MAFLD). Chronic inflammation crucial link between liver. An anti-inflammatory diet expected to be an essential measure prevent dietary inflammatory index (DII) tool for assessing potential diets. However, relationship DII unclear.

Язык: Английский

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Analysis of influencing factors of exercise systolic blood pressure response in nonalcoholic fatty liver disease aged 40–60 years

Postgraduate Medicine, Год журнала: 2024, Номер 137(1), С. 79 - 85

Опубликована: Ноя. 29, 2024

This study investigated the influencing factors of exercise systolic blood pressure response (ESBPR) by cardiopulmonary test (CPX) in nonalcoholic fatty liver disease (NAFLD) people aged 40-60 years. A total 603 adults were enrolled this study. The inclusion criteria cross-sectional who underwent health checks and CPX. There significant differences body mass Index (BMI) (26.80 ± 2.64 VS 23.31 2.41, p < 0.001) kg/m2, fasting glucose (FPG) (5.56 0.94 5.13 0.55, mmol/L, alanine aminotransferase (ALT), aspartate transaminase (AST), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C) (1.13 0.22 1.43 0.33, low-density (LDL-C) (3.21 0.79 2.99 0.68, = resting (SBP) (123.53 14.73 118.79 14.79, mmHg, diastolic (DBP) (80.29 9.62 75.27 10.41, peak SBP (184.01 23.50 172.81 24.95, DBP (87.47 10.50 84.01 11.46, oxygen pulse (VO2/HR) (0.88 0.15 0.92 0.16, 0.004) ml/beat, maximum heart rate, carbon dioxide Ventilation equivalent (VE/VCO2) (25.84 4.43 25.12 3.58, 0.038), uptake (VO2 peak) (1.78 0.45 1.56 0.46, mL/min between NAFLD control groups. VE/VCO2 (OR 0.822, 0.036) uptake/work rate (VO2/WR) 0.517, 0.021) mL/min/watt associated with a lower risk ESBPR subjects. Resting was higher patients 1.059, 0.003) overweight subjects 1.075, 0.002). 1.268, 0.045), skeletal-muscle 1.305, 0.001), SMI 1.315, linked to an elevated individuals. Our findings indicate that is increased individuals Furthermore, subjects, VO2/WR found be correlated decreased ESBPR, whereas ESBPR. will provide research basis for have at adverse events during exercise.

Язык: Английский

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Sex-dependent association of serum alkaline phosphatase with grip strength in adults aged 20-59: NHANES 2013-2014

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Background Serum alkaline phosphatase (ALP) plays a crucial role in bone and muscle health. Previous studies have demonstrated that serum is closely associated with mass. Nevertheless, the association between grip strength remains unclear. This study designed to investigate whether there exists connection ALP levels among individuals aged 20 59 years. Methods Utilizing data from National Health Nutrition Examination Survey (NHANES) conducted 2013–2014, cross-sectional survey design was employed examine 2,182 adults (54.54% male 45.46% female) Weight-corrected served as dependent variable, while identified primary variable of interest. The relationships were analyzed using generalized linear models, smooth curve fitting, additive stratified analyses. Results We discovered negatively linked weight-corrected strength. When by gender, age group race, for all groups except other races, correlated divided into four according gender age, showed an N-shaped relationship participants 20–39 years, L-shaped 40–59 female shows significant negative correlation regardless group. Conclusions Our research notable differences finding offers new insights avenues understanding how affects skeletal

Язык: Английский

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