Metabolic Syndrome and Related Disorders, Год журнала: 2024, Номер 22(9), С. 686 - 694
Опубликована: Июль 10, 2024
This study aims to investigate the prevalence of possible sarcopenia and its associated factors among middle-aged Vietnamese women.
Язык: Английский
Nutrients, Год журнала: 2023, Номер 16(1), С. 63 - 63
Опубликована: Дек. 25, 2023
Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) associated with faster more relevant impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk falls, frailty, overall quality life, mortality. PubMed/Medline, Scopus, Web Science, Google Scholar were searched for research articles, scientific reports, observational studies, trials, narrative systematic reviews, meta-analyses review evidence pathophysiology di-abetes-induced sarcopenia, its relevance in terms glucose control diabetes-related outcomes, diagnostic therapeutic challenges. The comprehensively addresses key elements definition criteria pathophysiological correlation be-tween T2D, related a critical role antihyperglycemic treatment health, perspectives specific targeting myokine signaling pathways involved regulation metabolism trophism. Prompt diagnosis adequate management, including lifestyle inter-vention, diet programs, micronutrient supplementation, physical exercise, pharmaco-logical treatment, are needed prevent or delay T2D.
Язык: Английский
Процитировано
31
Nutrients, Год журнала: 2024, Номер 16(7), С. 941 - 941
Опубликована: Март 25, 2024
Aging-related sarcopenia exerts harmful impacts on muscle mass, strength, and physical mobility. Protein supplementation has been demonstrated to augment efficacy of resistance training (RT) in elderly. This study compared the relative effects different protein supplements mobility outcomes middle-aged older individuals undergoing RT. A comprehensive search online databases was performed identify randomized controlled trials (RCTs) examining supplement plus RT untrained community-dwelling adults, hospitalized, or institutionalized residents who suffered acute chronic health conditions. Network meta-analysis (NMA) using a frequentist method for all analyses. Treatment main were expressed as standard mean difference (SMD) with 95% confidence interval (CI). We used surface-under-the cumulative-ranking (SUCRA) scores rank probabilities effect estimation among identified treatments. Meta-regression analyses any relevant moderator treatment results β credible (CrI). finally included 78 RCTs (5272 participants) Among six sources this NMA, namely whey, milk, casein, meat, soy, peanut, whey yielded most effective treatments augmenting mass (SMD = 1.29, CI: 0.96, 1.62; SUCRA 0.86), handgrip strength 1.46, 0.92, 2.00; 0.85), walking speed 0.73, 0.39, 1.07; 0.84). Participant's condition, sex, dose significant factors moderating (β 0.74; CrI: 0.22, 1.25), -1.72; -2.68, -0.77), leg 0.76; 0.06, 1.47), respectively. Our findings suggest yields optimal counter
Язык: Английский
Процитировано
8
BMC Endocrine Disorders, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 26, 2025
The Weight-adjusted-waist index (WWI) has emerged as a predictive factor for range of metabolic disorders. To date, the value WWI in relation to sarcopenia individuals with diabetics not been extensively explored. This study aims investigate impact on prevalence among patients type 2 diabetes mellitus (T2DM). In this study, we enrolled 417 T2DM from Second Affiliated Hospital and Yuying Children's Wenzhou Medical University between Dec. 2023 Apr. 2024. relationship was evaluated using multivariate logistic regression, subgroup analysis, restricted cubic spline (RCS) receiver operating characteristic (ROC) curve analysis. Among T2DM, 76 (18.22%) were identified having sarcopenia. across quartile categories, first fourth quartile, 8.65%, 8.57%, 20.19% 8.65% respectively. Multivariate regression analysis revealed that, after adjusting covariates, higher an independent risk male (OR = 1.836, 95% CI: 1.216-2.772, P 0.004). association observed female patients. Subgroup further stronger correlation HbA1c levels. males, RCS demonstrated non-linear positive correlation, inflection point at 10.42 cm/√kg. Finally, area under ROC (AUC) 0.612. emerges robust T2DM. may serve accessible cost-effective tool identify diabetes.
Язык: Английский
Процитировано
0
Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17
Опубликована: Фев. 5, 2025
Background Insulin resistance (IR) is recognized as a potential modifiable risk factor for cognitive decline, but findings within Asian populations have been inconsistent. Given the high prevalence of dementia and its substantial economic burden in China, large-scale longitudinal studies are essential to elucidate complex relationship between IR function. Methods This cohort study included 8,734 middle-aged older adults (median age: 58 years; 53.6% females) from China Health Retirement Longitudinal Study (CHARLS), followed 2011 2018. Estimated glucose disposal rate (eGDR) was used assess calculated using waist circumference, hypertension status, HbA1c levels. Participants were categorized into tertiles based on eGDR levels (Tertile 1: lowest; Tertile 3: highest). Cognitive function sum episodic memory executive scores, which then standardized Z -score. Linear mixed-effects models dose-response analyses performed evaluate association baseline changes total population stratified by sex. Results Higher significantly associated with slower global decline 3 vs. β = 0.007; 95% CI: 0.000–0.014; P 0.047). stronger females 0.011; 0.002–0.021; 0.021), while no significant observed males. Dose-response indicated linear positive females, not Similar patterns found function, associations predominantly females. Conclusion particularly among women. These underscore marker identifying mitigating highlight importance sex-specific strategies address insulin promote health.
Язык: Английский
Процитировано
0
World Journal of Hepatology, Год журнала: 2025, Номер 17(2)
Опубликована: Фев. 20, 2025
The etiology, risk factors, and management of sarcopenia metabolic dysfunction-associated steatotic liver disease (MASLD) are comparable, which prompted the investigators to search for a particular diagnostic or prognostic biomarker that was involved in both disorders. Peptides proteins known as myokines, exerkines, produced secreted by contracted muscles. Myokines work similarly hormones their actions. One common clinical hallmark MASLD is physical inactivity, associated with alterations levels myokines. Irisin positive regulator muscle size elevated biological fluids during exercise. Significantly low were observed pathological conditions inactivity. serum irisin significantly higher patients, while lower factors MASLD, e.g. , diabetes mellitus, obesity, insulin resistance. In obesity (sarcopenic obesity) normal build, than healthy subjects. Therefore, serial determination showed transition from indicated development those patients.
Язык: Английский
Процитировано
0
Menopause The Journal of The North American Menopause Society, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Abstract Objective Little is known about the longitudinal associations between creatinine-cystatin C ratios (CCR) with muscle volume and function during menopausal transition. We investigated relationship of baseline CCR, volumes measured by magnetic resonance imaging (MRI), objectively strength physical performance after 6.6-year follow-up. Methods Participants from Integrated Women's Health Programme (IWHP) cohort (n = 891, mean age 56.2 ± 6.0) who attended both follow-up visits underwent assessments MRI. Creatinine to cystatin ratio was calculated as (creatinine [mg/dL] / [mg/L]) low CCR were those in lowest tertile (CCR < 8.16). Multivariable regression analyses used determine 6.6 years later. Results Baseline associated lower MRI-measured poorer Compared high group, fat-free thigh group 0.350 L (95% CI, 0.183‐0.518) adjustment for covariates. Similarly, 0.029 m/s slower 0.006‐0.053) usual gait 0.049 0.020‐0.078) narrow speeds. not handgrip repeated chair stands one-leg stand tests. Conclusion Low at speeds The potential a predictive biomarker adverse events related sarcopenia midlife women merits further investigation.
Язык: Английский
Процитировано
0
Asian Journal of Surgery, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
2
Archives of Gerontology and Geriatrics, Год журнала: 2023, Номер 117, С. 105248 - 105248
Опубликована: Окт. 22, 2023
The Asian Working Group for Sarcopenia (AWGS) introduced the concept of "possible sarcopenia" in 2019. However, association between possible sarcopenia and hip fracture is not well characterized. Hence, we conducted a study to explore this older Chinese adults.
Язык: Английский
Процитировано
3
Clinical Nutrition, Год журнала: 2024, Номер 43(6), С. 1499 - 1500
Опубликована: Апрель 24, 2024
Язык: Английский
Процитировано
0
Metabolic Syndrome and Related Disorders, Год журнала: 2024, Номер 22(9), С. 686 - 694
Опубликована: Июль 10, 2024
This study aims to investigate the prevalence of possible sarcopenia and its associated factors among middle-aged Vietnamese women.
Язык: Английский
Процитировано
0