Psychotropic Polypharmacy in Dementia: A Retrospective Analysis for People with Neuropsychiatric Symptoms Referred to an Australian Dementia Support Service
Drugs & Aging,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Despite
their
limited
benefits
and
serious
adverse
effects,
psychotropics
remain
frequently
prescribed
for
neuropsychiatric
symptoms
(NPS)
of
dementia.
Psychotropic
polypharmacy,
the
use
two
or
more
concomitant
psychotropic
medications,
is
therefore
not
recommended
people
with
The
objectives
this
study
were
to
investigate
prevalence
polypharmacy
in
Australians
living
dementia
whose
caregivers
sought
external
NPS
support
from
Dementia
Support
Australia
(DSA;
national
provider
support)
association
demographics
characteristics.
A
retrospective
cross-sectional
a
subset
DSA
referrals
at
baseline
(i.e.,
yet
receive
psychosocial
intervention(s))
between
2016
2020
was
conducted.
Referrals
without
compared
on
basis
demographic
characteristics
(e.g.,
sex,
subtype),
type
agitation),
severity
associated
caregiver
distress
as
measured
by
Neuropsychiatric
Inventory
(NPI),
using
Pearson's
chi-square
test
Welch's
t-test
categorical
continuous
data,
respectively.
Logistic
regression
models
used
examine
relationship
individual
NPI
domains
exposure
polypharmacy.
total
421
(mean
age
81.5
(standard
deviation
8.5)
years,
52.3%
males,
46.8%
Alzheimer's
disease)
analysed.
Of
those,
over
90%
(n
=
383)
least
one
psychotropic,
214
(50.8%)
medication
types
most
antipsychotics
162,
75.7%),
opioids
104,
48.6%),
anxiolytics
93,
43.5%),
sedative/hypnotics
52,
24.3%)
antidepressants
47,
22.0%).
No
any
variable
tested
identified,
including
age,
subtype
severity.
highly
prevalent
referred
dementia-specific
behaviour
programs,
but
no
factors
its
presence
cohort.
Язык: Английский
Neuropsychiatric Symptoms and Psychotropic Medication Use Following SARS-Cov-2 Infection Among Elderly Residents in Long-Term Care Facilities
Canadian Geriatrics Journal,
Год журнала:
2025,
Номер
28(1), С. 67 - 72
Опубликована: Март 5, 2025
SARS-CoV-2
infection
can
lead
to
persistent
post-acute
neuropsychiatric
symptoms.
Older
adults
with
multimorbidity
may
be
at
increased
risk
of
symptoms
after
COVID-19.
The
goals
the
present
study
were
assess
associations
and
psychotropic
medication
prescription
among
older
living
in
long-term
care
facilities.
Nursing
home
residents
(n=111)
participated
this
three-month
longitudinal
study.
Nurse
ratings
conducted
baseline
follow-up.
status
extracted
from
a
medical
chart
review.
About
73.9%
participants
infected
on
average
480.49
(SD=
228)
days
before
enrollment.
There
no
significant
changes
during
follow-up
period.
Participants
had
more
agitation
compared
those
who
never
infected.
However,
effect
disappeared
adjusting
for
age,
sex,
history
psychiatric
disorder,
neurocognitive
status,
multimorbidity.
higher
number
prescription.
This
was
driven
by
use
antidepressants
antipsychotic
medications.
Both
acute
short-term
associated
COVID-19
contribute
psychoactive
polypharmacy
Язык: Английский