American Journal of Translational Research,
Год журнала:
2024,
Номер
16(12), С. 7448 - 7457
Опубликована: Янв. 1, 2024
Intrahepatic
cholestasis
of
pregnancy
(ICP)
is
the
most
common
liver
condition
during
pregnancy,
associated
with
adverse
outcomes
for
both
mother
and
fetus.
While
inflammatory
markers
are
important
predictors
in
oncology
cardiovascular
disease,
their
role
ICP
remains
unclear.
This
study
investigates
changes
platelet
parameters
blood-derived
around
onset
evaluates
potential
as
independent
risk
factors.
retrospective
analyzed
markers,
including
Neutrophil-to-Lymphocyte
Ratio
(NLR),
Derived
NLR
(dNLR),
Monocyte-to-Lymphocyte
(MLR),
Neutrophil-Monocyte-to-Lymphocyte
(NMLR),
Systemic
Inflammation
Response
Index
(SIRI),
Immune-Inflammation
(SII)
along
variations
49
patients
250
healthy
controls
late
specifically
at
disease
onset.
Additionally,
these
were
assessed
among
same
compared
to
1439
early
pregnancy.
During
an
episode
ICP,
individuals
exhibited
increased
parameters,
PCT,
P-LCR,
PDW
MPV,
those
uncomplicated
pregnancies.
The
levels
WBC,
NEUT,
NLR,
dNLR,
NMLR,
SIRI,
SII
also
elevated
group
relative
control
group.
Prior
onset,
such
PCT
PDW,
SII,
significantly
higher
patients.
a
notable
increase
HGB,
HCT,
MCV,
MCH,
RDW-CV
was
observed
group,
while
MCHC
decreased.
Logistic
regression
analysis
identified
factors
developing
ICP.
before
progression
Notably,
factors,
representing
new
predictive
indicators
development
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 997 - 997
Опубликована: Апрель 20, 2025
Background:
Hypertrophic
cardiomyopathy
(HCM)
is
a
prevalent
condition
that
often
coexists
with
chronic
kidney
disease
(CKD),
significantly
impacting
patient
prognosis.
This
study
aimed
to
investigate
the
predictive
value
of
complete
blood
cell
counts
derived
inflammatory
indicators
in
assessing
CKD
risk
HCM
patients.
Methods:
enrolled
patients
and
categorized
them
into
non-CKD
group
based
on
discharge
diagnoses.
Analyzed
included
systemic
inflammation
response
index
(SIRI),
immune
(SII),
neutrophil-to-lymphocyte
ratio
(NLR),
platelet-to-lymphocyte
(PLR).
Least
absolute
shrinkage
selection
operator
(LASSO)
logistic
multivariable
regression
were
employed
identified
independent
factors
for
CKD,
which
subsequently
utilized
develop
nomogram.
Results:
A
total
1795
included,
including
112
(6.24%)
individuals
assigned
group.
In
univariate
analyses,
NLR
(AUC:
0.755;
95%CI:
0.711–0.800)
demonstrated
superior
accuracy
compared
others.
Eighteen
baseline
characteristics
exhibiting
statistical
difference
incorporated
LASSO-logistic
regression.
Six
further
selected
by
The
results
male
gender
(OR:
2.622;
95%
CI:
1.565–4.393,
p
<
0.001),
Hb
0.972;
0.962–0.981,
Pro-BNP
1.000;
1.000–1.000,
SIRI
1.037;
1.026–1.049,
SII
1.000–1.001,
=
0.003)
as
factors.
These
five
used
construct
nomogram,
exhibited
good
consistency.
Conclusions:
Male
gender,
Hb,
Pro-BNP,
SIRI,
nomogram
was
developed
using
these
factors,
may
facilitate
early
identification
management
high-risk
individuals.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 25, 2025
Introduction
Prostate
cancer
(PCa)
is
a
prevalent
malignancy
in
men
globally.
The
total
prostate-specific
antigen
(TPSA)
test
essential
for
PCa
screening.
neutrophil-and-monocyte-to-lymphocyte
ratio
(NMLR)
has
emerged
as
potential
biomarker
various
diseases,
but
its
relationship
with
and
TPSA
yet
to
be
studied.
This
research
aims
explore
the
connection
between
NMLR
levels,
well
high-risk
prostate
(HRPCa),
utilizing
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2003
2008.
Methods
study
included
4,248
U.S.
adult
males.
was
calculated
of
combined
counts
peripheral
neutrophils
monocytes
lymphocytes.
Weighted
multiple
linear
logistic
regression
models
were
used
analyze
NMLR,
HRPCa.
Results
A
significant
positive
association
found
elevated
levels
increased
(β
=
0.35,
95%
CI:
0.21–0.49),
higher
odds
HRPCa
(OR
2.04,
1.55–2.68).
Smooth
curve
fitting
results
indicate
that
there
nonlinear
correlation
TPSA,
HRCa.
Conclusion
reveals
among
males,
suggesting
could
valuable
assessing
risk,
underscoring
inflammation’s
role
health.
Further
encouraged
applications
early
detection,
treatment
efficacy
evaluation
risk
stratification.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(9), С. 3038 - 3038
Опубликована: Апрель 28, 2025
Background/Objectives:
The
analysis
of
the
complete
blood
count
(CBC)-derived
inflammatory
indexes
across
different
histological
subtypes
lung
cancer
supports
early
detection
tumor-induced
inflammation
and
has
a
good
predictive
value
for
severity
in
patients.
main
objective
this
article
was
to
assess
variations
CBC-derived
markers
histologic
cancer,
with
final
goal
identifying
specific
predictors
each
subtype
cancer.
Methods:
We
conducted
retrospective
descriptive
study
that
included
202
patients
diagnosed
carcinoma
at
Clinical
County
Hospital
Mureș.
analyzed
parameters
were
as
follows:
type,
stage
tumor,
patients’
general
data,
associated
comorbidities.
In
addition,
nine
indexes,
like
neutrophil-to-lymphocyte
ratio
(NLR),
derived
(d-NLR),
monocyte-to-lymphocyte
(MLR),
platelet-to-lymphocyte
(PLR),
eosinophil-to-neutrophil
(ENR),
eosinophil-to-monocyte
(EMR),
systemic
index
(SII),
response
(SIRI),
aggregate
(AISI),
correlated
findings.
Results:
differed
subtypes.
SIRI,
d-NLR,
age
adenocarcinoma
patients,
while
ENR,
leukocyte,
neutrophil
predicted
squamous
cell
carcinoma.
For
SCLC
AISI,
SII,
EMR,
MLR,
leukocyte
count,
lymphocyte
platelets
COPD,
smoking,
male
gender
severity.
Conclusions:
Understanding
complexity
types
can
personalize
treatment
regimens
target
abnormal
cellular
lines,
thus
improving
outcome
highly
deadly
condition.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 28, 2024
Remnant
cholesterol
(RC)
is
a
novel
lipid
metabolism
indicator;
however,
its
relationship
with
sarcopenia
has
not
been
clearly
established.
This
study
was
conducted
to
explore
the
association
between
RC
and
sarcopenia.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
In
the
context
of
an
aging
global
population
and
imperative
for
innovative
healthcare
solutions,
concept
longevity
clinics
emerges
as
a
timely
vital
area
exploration.
Unlike
traditional
medical
facilities,
offer
unique
approach
to
preclinical
prevention,
focusing
on
"prevention
prevention"
through
utilization
clocks
biomarkers
from
healthy
individuals.
This
article
presents
comprehensive
overview
clinics,
encompassing
descriptions
existing
models,
development
proposed
framework,
insights
into
biomarkers,
wearable
devices,
therapeutic
interventions.
Additionally,
economic
justifications
investing
in
are
examined,
highlighting
significant
growth
potential
biotechnology
market
its
alignment
with
goals
achieving
active
longevity.
Anchored
by
Analytical
Center,
framework
underscores
importance
data-driven
decision-making
innovation
promoting
prolonged
enhanced
human
life.
At
present,
there
is
no
universally
accepted
standard
model
clinics.
absence
highlights
need
additional
research
ongoing
improvements
this
field.
Through
synthesis
scientific
practical
considerations,
aims
stimulate
further
discussion
field
ultimately
contributing
advancement
practices
aimed
at
extending
enhancing
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 30, 2024
Erectile
dysfunction(ED),
a
prevalent
condition
within
the
male
genitourinary
system,
significantly
impairs
quality
of
life
for
affected
men.
Although
certain
inflammatory
indicators,
such
as
neutrophil-to-lymphocyte
ratio(NLR),
systemic
response
index
(SIRI),
and
immune-inflammation
index(SII),
have
been
linked
to
ED,
correlation
with
other
markers
their
impact
on
survival
outcomes
in
ED
patients
remain
largely
unexplored.
This
research
aims
investigate
between
biomarkers
derived
from
complete
blood
cell
count(CBC)
occurrence
ED.
Data
regarding
were
extracted
2001-2004
National
Health
Nutrition
Examination
Survey(NHANES),
mortality
events
ascertained
through
Death
Index
up
December
2019.
The
CBC-derived
indicators
assessed
this
study
included
NLR,
ratio(dNLR),
monocyte-to-lymphocyte
ratio(MLR),
neutrophil-monocyte
lymphocyte
ratio
(NMLR),
SIRI,
SII.
prognostic
significance
these
was
evaluated
using
random
forests(RSF)
analysis.
Our
encompassed
cohort
3,639
individuals,
among
whom
1,031
diagnosed
Among
individuals
610
experienced
all-cause
mortality.
Following
adjustment
all
confounding
variables,
it
observed
that
elevated
levels
NLR(OR
=
1.09,
95%CI
1.00-1.19,
p
0.021),
MLR
(OR
2.97,
95%
CI
1.18-7.50,
0.01),
NMLR(OR
1.10,
1.01-1.11,
0.006),
SIRI(OR
1.11,
1.01-1.22,
0.017)
associated
an
increased
prevalence
participants
those
highest
quartile
NLR(HR
1.06,
1.00-1.11,
0.032),
MLR(HR
2.00,
1.33-3.01,
<
0.001),
NMLR
(HR
0.024),
SII(HR
1.00,
1.00-1.00,
0.015)
exhibited
risk
compared
lower
inflammation-derived
indicators.
suggests
that,
count,
has
predictive
power
populations.
American Journal of Translational Research,
Год журнала:
2024,
Номер
16(12), С. 7448 - 7457
Опубликована: Янв. 1, 2024
Intrahepatic
cholestasis
of
pregnancy
(ICP)
is
the
most
common
liver
condition
during
pregnancy,
associated
with
adverse
outcomes
for
both
mother
and
fetus.
While
inflammatory
markers
are
important
predictors
in
oncology
cardiovascular
disease,
their
role
ICP
remains
unclear.
This
study
investigates
changes
platelet
parameters
blood-derived
around
onset
evaluates
potential
as
independent
risk
factors.
retrospective
analyzed
markers,
including
Neutrophil-to-Lymphocyte
Ratio
(NLR),
Derived
NLR
(dNLR),
Monocyte-to-Lymphocyte
(MLR),
Neutrophil-Monocyte-to-Lymphocyte
(NMLR),
Systemic
Inflammation
Response
Index
(SIRI),
Immune-Inflammation
(SII)
along
variations
49
patients
250
healthy
controls
late
specifically
at
disease
onset.
Additionally,
these
were
assessed
among
same
compared
to
1439
early
pregnancy.
During
an
episode
ICP,
individuals
exhibited
increased
parameters,
PCT,
P-LCR,
PDW
MPV,
those
uncomplicated
pregnancies.
The
levels
WBC,
NEUT,
NLR,
dNLR,
NMLR,
SIRI,
SII
also
elevated
group
relative
control
group.
Prior
onset,
such
PCT
PDW,
SII,
significantly
higher
patients.
a
notable
increase
HGB,
HCT,
MCV,
MCH,
RDW-CV
was
observed
group,
while
MCHC
decreased.
Logistic
regression
analysis
identified
factors
developing
ICP.
before
progression
Notably,
factors,
representing
new
predictive
indicators
development
