Changes in brain functional connectivity of patients with postoperative delirium DOI Creative Commons
Tuo Deng, Chao Tan,

Guangkuo Ma

и другие.

Perioperative Precision Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Postoperative delirium (POD) is an acute cognitive disorder marked by attention deficits, fluctuating symptoms, and significant impairment. These features are closely associated with adverse outcomes, including increased mortality, prolonged hospitalization, long-term elevated healthcare costs. Brain functional connectivity studies focus on understanding complex neuronal interactions interregional communication within the brain. This article explores association between POD brain connectivity. It begins summarizing prominent of as a common postoperative complication its substantial impact patient health, highlighting current limitations in pathophysiological mechanisms. The then investigates relationship function, emphasizing role advanced monitoring techniques, Electroencephalography Functional Magnetic Resonance Imaging. advantages these technologies studying discussed. Additionally, focuses posterior cingulate cortex Default Mode Network, examining their roles development potential connections to pathogenesis. Finally, application graph theory analysis introduced, offering new insights into POD’s Based evidence, provides outlook future research directions challenges. study particularly emphasizes perioperative factors, such anesthesia inflammation, changes may trigger disrupting Network other key neural networks. By investigating patterns patients undergoing different types surgeries, this further reveals contribution factors mechanisms POD.

Язык: Английский

Exploring bacterial key genes and therapeutic agents for breast cancer among the Ghanaian female population: Insights from In Silico analyses DOI Creative Commons
Md. Kaderi Kibria, Md. Ahad Ali, Md. Nurul Haque Mollah

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(11), С. e0312493 - e0312493

Опубликована: Ноя. 25, 2024

Breast cancer (BC) is yet a significant global health challenge across various populations including Ghana, though several studies on host-genome associated with BC have been investigated molecular mechanisms of development and progression, candidate therapeutic agents. However, little attention has given microbial genome in this regard, although alterations microbiota epigenetic modifications are recognized as substantial risk factors for BC. This study focused identifying bacterial key genes (bKGs) infections the Ghanaian population exploring potential drug molecules by targeting these bKGs through silico analyses. At first, 16S rRNA sequence data were downloaded from NCBI database comprising 520 samples patients 442 healthy controls. Analysis rRNA-Seq showed differences abundance between groups identified 26 differential genera threshold values at |log2FC|>2.0 p-value≤0.05. It was observed that two Prevotella Anaerovibria significantly upregulated others downregulated. Functional analysis based all 19 MetaCyc signaling pathways, twelve which enriched containing 165 Top-ranked 10 mdh, pykF, gapA, zwf, pgi, tpiA, pgk, pfkA, ppsA, pykA BC-causing protein-protein interaction network analysis. Subsequently, bKG-guided top ranked Digitoxin, Digoxin, Ledipasvir, Suramin, Ergotamine, Venetoclax, Nilotinib, Conivaptan, Dihydroergotamine, Elbasvir using docking The stability top-ranked three drug-target complexes (Digitoxin-pykA, Digoxin-mdh, Ledipasvir-pgi) confirmed dynamics simulation studies. Therefore, findings might be useful resources to wet-lab researchers further experimental validation therapies against

Язык: Английский

Процитировано

1
Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways DOI Open Access
Kenneth Maiese

World Journal of Cardiology, Год журнала: 2024, Номер 16(11), С. 632 - 643

Опубликована: Окт. 30, 2024

As a non-communicable disease, cardiovascular disorders have become the leading cause of death for men and women. Of additional concern is that disease linked to chronic comorbidity include nonalcoholic fatty liver (NAFLD). NAFLD, also termed metabolic-dysfunction-associated steatotic greatest throughout world, increasing in prevalence concurrently with diabetes mellitus (DM), can progress steatohepatitis leads cirrhosis fibrosis. Individuals metabolic disorders, such as DM, are more than two times likely experience cardiac stroke, includes NAFLD when compared individuals without disorders. Interestingly, share common underlying cellular mechanism pathology, namely silent mating type information regulation 2 homolog 1 (SIRT1;

Язык: Английский

Процитировано

0
Changes in brain functional connectivity of patients with postoperative delirium DOI Creative Commons
Tuo Deng, Chao Tan,

Guangkuo Ma

и другие.

Perioperative Precision Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Postoperative delirium (POD) is an acute cognitive disorder marked by attention deficits, fluctuating symptoms, and significant impairment. These features are closely associated with adverse outcomes, including increased mortality, prolonged hospitalization, long-term elevated healthcare costs. Brain functional connectivity studies focus on understanding complex neuronal interactions interregional communication within the brain. This article explores association between POD brain connectivity. It begins summarizing prominent of as a common postoperative complication its substantial impact patient health, highlighting current limitations in pathophysiological mechanisms. The then investigates relationship function, emphasizing role advanced monitoring techniques, Electroencephalography Functional Magnetic Resonance Imaging. advantages these technologies studying discussed. Additionally, focuses posterior cingulate cortex Default Mode Network, examining their roles development potential connections to pathogenesis. Finally, application graph theory analysis introduced, offering new insights into POD’s Based evidence, provides outlook future research directions challenges. study particularly emphasizes perioperative factors, such anesthesia inflammation, changes may trigger disrupting Network other key neural networks. By investigating patterns patients undergoing different types surgeries, this further reveals contribution factors mechanisms POD.

Язык: Английский

Процитировано

0