Indication of frailty transitions on 2-year adverse health outcomes among older Chinese inpatients: Insight from a multicenter prospective cohort study DOI Creative Commons
Miao Yu, Jiaqi Ding, Xinjuan Wu

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0313775 - e0313775

Опубликована: Янв. 8, 2025

Introduction Frailty is thought to be associated with an increased risk of adverse health outcomes such as death and falls, but comparatively little known about the impact frailty transitions on outcomes. Moreover, owing insufficient sample size or a single-center study design, previous studies have not been sufficiently representative elderly inpatients in China. This aimed provide estimates at population level association between among following discharge. Methods was large-scale multicenter cohort conducted from October 2018 February 2021. The FRAIL scale used estimate status. were derived by considering status baseline 3-month follow-up, which encompassed five patterns: persistent non-frailty, pre-frailty, frailty, improvement worsening frailty. outcome variables included mortality, hospital readmissions, Health-Related Quality Life (HRQoL). Cox proportional hazard regression, generalized linear models regression examine Results A total 8,256 patients study, 40.70% participants non-frail, 43.04% pre-frail, 16.27% frail. Compared who persistently non-frail patients, those improvement, showcased escalated risks mortality within 2 years after enrollment [ HR (95% CI): 1.32 (1.06–1.64)], 1.71 (1.37–2.13), 2.43 (1.95–3.02), 2.44 (1.81–3.29), respectively. These groups also faced elevated hazards 2-year falls OR 1.586(1.13–2.23), 2.21(1.55–3.15), 1.94(1.33–2.82), 2.71(1.59–4.62)] re-hospitalization years[ 1.33(1.13–1.56), 1.56(1.32–1.86), 1.53(1.28–1.83), 2.29(1.74–3.01). number 0.76 over frailty-worsened 0.81 pre-frail patients. days rehospitalization 0.35 frailty-improved 0.61 0.66 0.80 frail exhibiting [-1.23 CI: -2.12 -0.35)], pre-frail[-4.95 -5.96 -3.94)], [-3.67 -4.71 -2.62)], [-9.76 -11.60 -7.93)] displayed inverse correlations coefficients HRQoL. Discussion Frailty-improved, worsened, face higher rehospitalization, reduced HRQoL than consistently inpatients. Screening for can identify individuals

Язык: Английский

Indication of frailty transitions on 2-year adverse health outcomes among older Chinese inpatients: Insight from a multicenter prospective cohort study DOI Creative Commons
Miao Yu, Jiaqi Ding, Xinjuan Wu

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0313775 - e0313775

Опубликована: Янв. 8, 2025

Introduction Frailty is thought to be associated with an increased risk of adverse health outcomes such as death and falls, but comparatively little known about the impact frailty transitions on outcomes. Moreover, owing insufficient sample size or a single-center study design, previous studies have not been sufficiently representative elderly inpatients in China. This aimed provide estimates at population level association between among following discharge. Methods was large-scale multicenter cohort conducted from October 2018 February 2021. The FRAIL scale used estimate status. were derived by considering status baseline 3-month follow-up, which encompassed five patterns: persistent non-frailty, pre-frailty, frailty, improvement worsening frailty. outcome variables included mortality, hospital readmissions, Health-Related Quality Life (HRQoL). Cox proportional hazard regression, generalized linear models regression examine Results A total 8,256 patients study, 40.70% participants non-frail, 43.04% pre-frail, 16.27% frail. Compared who persistently non-frail patients, those improvement, showcased escalated risks mortality within 2 years after enrollment [ HR (95% CI): 1.32 (1.06–1.64)], 1.71 (1.37–2.13), 2.43 (1.95–3.02), 2.44 (1.81–3.29), respectively. These groups also faced elevated hazards 2-year falls OR 1.586(1.13–2.23), 2.21(1.55–3.15), 1.94(1.33–2.82), 2.71(1.59–4.62)] re-hospitalization years[ 1.33(1.13–1.56), 1.56(1.32–1.86), 1.53(1.28–1.83), 2.29(1.74–3.01). number 0.76 over frailty-worsened 0.81 pre-frail patients. days rehospitalization 0.35 frailty-improved 0.61 0.66 0.80 frail exhibiting [-1.23 CI: -2.12 -0.35)], pre-frail[-4.95 -5.96 -3.94)], [-3.67 -4.71 -2.62)], [-9.76 -11.60 -7.93)] displayed inverse correlations coefficients HRQoL. Discussion Frailty-improved, worsened, face higher rehospitalization, reduced HRQoL than consistently inpatients. Screening for can identify individuals

Язык: Английский

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