The prognostic significance of stress hyperglycemia ratio in evaluating all-cause and cardiovascular mortality risk among individuals across stages 0–3 of cardiovascular–kidney–metabolic syndrome: evidence from two cohort studies
Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Март 24, 2025
The
American
Heart
Association
(AHA)
proposed
the
concept
of
cardiovascular–kidney–metabolic
(CKM)
syndrome,
underscoring
interconnectedness
cardiovascular,
renal,
and
metabolic
diseases.
stress
hyperglycemia
ratio
(SHR)
represents
an
innovative
indicator
that
quantifies
blood
glucose
fluctuations
in
patients
experiencing
acute
or
subacute
stress,
correlating
with
detrimental
clinical
effects.
Nevertheless,
prognostic
significance
SHR
within
individuals
diagnosed
CKM
syndrome
stages
0
to
3,
particularly
respect
all-cause
cardiovascular
disease
(CVD)
mortality
risks,
has
not
been
fully
understood
yet.
current
study
analyzed
data
from
9647
participants
covering
based
on
NHANES
(National
Health
Nutrition
Examination
Survey)
collected
2007
2018.
In
this
study,
primary
exposure
variable
was
SHR,
computed
as
fasting
plasma
divided
by
(1.59
*
HbA1c
−
2.59).
main
endpoints
were
well
CVD
mortality,
death
registration
sourced
through
December
31,
2019.
CHARLS
database
(China
Retirement
Longitudinal
Study)
utilized
validation
enhance
reliability
findings.
This
included
participants,
who
followed
for
a
median
duration
6.80
years.
During
period,
630
cases
135
CVD-related
deaths
total
recorded.
After
full
adjustment
covariates,
our
results
displayed
robust
positive
association
(Hazard
[HR]
=
1.09,
95%
Confidence
interval
[CI]
1.04–1.13).
However,
exhibited
no
significant
relationship
(HR
1.00,
CI
0.91–1.11).
mediation
analysis
suggested
between
risk
is
partially
mediated
RDW,
albumin,
RAR.
Specifically,
mediating
effects
17.0%
(95%
46.7%,
8.7%),
10.1%
23.9%,
4.7%),
23.3%
49.0%,
13.0%),
respectively.
Additionally,
analyses
indicated
correlation
among
across
0–3
during
follow-up
period
2011
2020.
An
increased
value
positively
associated
elevated
likelihood
0–3,
yet
it
shows
mortality.
important
tool
predicting
long-term
adverse
outcomes
population.
Cardiovascular–kidney–metabolic
emphasizes
kidney,
novel
marker
reflecting
stress-induced
fluctuations,
but
its
(stages
0–3)
remains
uncertain.
explores
Our
findings
indicate
significantly
1.04–1.13),
CI:
Mediation
Validation
using
supports
these
These
suggest
could
serve
biomarker
patients,
offering
potential
utility
stratification
management.
Язык: Английский
Red blood cell distribution width-to-albumin ratio and its association with age-related macular degeneration: a population-based cross-sectional study
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 15, 2025
Background
Age-related
macular
degeneration
(AMD)
is
a
leading
cause
of
central
vision
impairment
in
middle-aged
and
older
individuals.
There
substantial
evidence
that
AMD
associated
with
inflammation.
The
study
aimed
to
investigate
the
association
between
inflammatory
marker,
red
blood
cell
distribution
width/albumin
ratio
(RAR),
AMD.
Methods
Our
included
5,370
participants
aged
40
years
older,
using
NHANES
data
from
2005
2008.
Multivariable
logistic
regression
analysis
was
conducted
examine
relationship
RAR
study.
Smooth
curves
piecewise
linear
model
were
used
determine
whether
correlation
or
non-linear.
Additionally,
subgroup
interaction
testing
performed.
Results
We
found
positive
AMD,
even
after
adjusting
for
covariates.
Each
unit
increase
corresponded
30%
odds
prevalence
(OR
=
1.3;
95%
CI,
1.0–1.6).
1.7
times
greater
highest
quintile
(Q5)
group
than
lowest
(Q1)
1.7;
1.2–2.5).
Higher
values,
compared
lower
significantly
increased
(
p
trend
<
0.05).
Subgroup
analyses
tests
confirmed
stability
findings.
Conclusion
This
there
United
States
adults.
Further
research
necessary
clarify
specific
physiological
mechanisms
underlying
Язык: Английский