The optimisation of public health emergency governance: a simulation study based on COVID-19 pandemic control policy DOI Creative Commons
Keng Yang, Hanying Qi

Globalization and Health, Год журнала: 2023, Номер 19(1)

Опубликована: Дек. 4, 2023

Abstract Background The outbreak of the COVID-19 pandemic sparked numerous studies on policy options for managing public health emergencies, especially regarding how to choose intensity prevention and control maintain a balance between economic development disease prevention. Methods We constructed cost-benefit model policies based an epidemic transmission model. On this basis, numerical simulations were performed different economies analyse dynamic evolution policies. These include areas with high costs, as seen in high-income economies, relatively low exhibited upper-middle-income economies. Results simulation results indicate that, at outset pandemic, both high-and low-cost tended enforce intensive interventions. However, virus evolved, particularly circumstances rates reproduction, short incubation periods, spans infection mortality rates, high-cost became inclined ease restrictions, while took opposite approach. consideration additional costs incurred by non-infected population means that economy is likely lift restrictions well. Conclusions This study concludes variations among nations varying income levels stem from variances characteristics, development, costs. can help researchers policymakers better understand differences choice various well changing trends choices, thus providing certain reference value direction global emergencies.

Язык: Английский

Sequence analysis of the Spike, nsp12 (RNA-dependent RNA polymerase), nsp3 (PLpro), and nsp5 (3CLpro) genes reveals a distinct evolutionary pattern of SARS-CoV-2 variants circulating in Yogyakarta and Central Java provinces, Indonesia DOI Open Access
Mohamad S. Hakim,

Gunadi Gunadi,

Ayu Rahayu

и другие.

Authorea (Authorea), Год журнала: 2023, Номер unknown

Опубликована: Май 10, 2023

During the Covid-19 pandemic, resurgence of SARS-CoV-2 was due to development novel variants concern (VOC). Thus, genomic surveillance is essential monitor continuing evolution and track emergence variants. In this study, we performed phylogenetic, mutation, selection pressure analyses Spike, nsp12, nsp3, nsp5 genes isolates circulating in Yogyakarta Central Java provinces, Indonesia from May 2021 February 2022. Various bioinformatics tools were employed investigate evolutionary dynamics distinct isolates. study period, 213 139 Omicron Delta identified, respectively. Particularly Spike gene, mutations significantly more abundant than Consistently, all four studied, substitution rates higher that variants, especially nsp12 genes. addition, selective analysis revealed several sites positively selected particular genes, implying these functionally for virus evolution. conclusion, our demonstrated a pattern Indonesia.

Язык: Английский

Процитировано

0
The optimisation of public health emergency governance: a simulation study based on COVID-19 pandemic control policy DOI Creative Commons
Keng Yang, Hanying Qi

Globalization and Health, Год журнала: 2023, Номер 19(1)

Опубликована: Дек. 4, 2023

Abstract Background The outbreak of the COVID-19 pandemic sparked numerous studies on policy options for managing public health emergencies, especially regarding how to choose intensity prevention and control maintain a balance between economic development disease prevention. Methods We constructed cost-benefit model policies based an epidemic transmission model. On this basis, numerical simulations were performed different economies analyse dynamic evolution policies. These include areas with high costs, as seen in high-income economies, relatively low exhibited upper-middle-income economies. Results simulation results indicate that, at outset pandemic, both high-and low-cost tended enforce intensive interventions. However, virus evolved, particularly circumstances rates reproduction, short incubation periods, spans infection mortality rates, high-cost became inclined ease restrictions, while took opposite approach. consideration additional costs incurred by non-infected population means that economy is likely lift restrictions well. Conclusions This study concludes variations among nations varying income levels stem from variances characteristics, development, costs. can help researchers policymakers better understand differences choice various well changing trends choices, thus providing certain reference value direction global emergencies.

Язык: Английский

Процитировано

0