Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production DOI Creative Commons
Qi Xu, Xiaoxuan Liu, Heng Heng

и другие.

PLoS Pathogens, Год журнала: 2025, Номер 21(3), С. e1012979 - e1012979

Опубликована: Март 17, 2025

Klebsiella pneumoniae ( Kp ) is responsible for a wide range of infections, including pneumonia, sepsis, and urinary tract infections. However, the treatment options are limited due to continuous evolution drug-resistant hypervirulent variants. It crucial investigate mechanisms behind high mortality rate (hv strains develop new strategies preventing hv from evading host’s defenses improving effectiveness these fatal In this study, we used -induced mouse bacteremia model performed single-cell RNA sequencing effects infection. Our findings demonstrated that infection led decrease in lymphocytes (lymphopenia), attributed impaired proliferation apoptosis. The infiltration myeloid-derived suppressor cells (MDSCs) infected lungs was confirmed suppress T cell proliferation, leading lymphopenia. We further identified promotes tryptophan metabolism lungs, enhancing immunosuppressive activity MDSCs by inducing production enzyme IDO1. ex vivo inhibition experiment revealed L-kynurenine, product metabolism, inhibits T-cell induces apoptosis, suppressing mediated responses against bacteria. Importantly, when knocked out Ido1 gene or inhibited IDO1 expression using specific inhibitor 1-MT mice, observed significant enhancement . These highlight role suggest promising immunotherapeutic approach inhibiting combat infectious diseases.

Язык: Английский

In vivo imaging to trace the dissemination of Aeromonas hydrophila in Common carp (Cyprinus carpio) after intestinal infection DOI

Yiran Wang,

Yijie Li,

P.C. Wang

и другие.

Fish & Shellfish Immunology, Год журнала: 2025, Номер unknown, С. 110276 - 110276

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production DOI Creative Commons
Qi Xu, Xiaoxuan Liu, Heng Heng

и другие.

PLoS Pathogens, Год журнала: 2025, Номер 21(3), С. e1012979 - e1012979

Опубликована: Март 17, 2025

Klebsiella pneumoniae ( Kp ) is responsible for a wide range of infections, including pneumonia, sepsis, and urinary tract infections. However, the treatment options are limited due to continuous evolution drug-resistant hypervirulent variants. It crucial investigate mechanisms behind high mortality rate (hv strains develop new strategies preventing hv from evading host’s defenses improving effectiveness these fatal In this study, we used -induced mouse bacteremia model performed single-cell RNA sequencing effects infection. Our findings demonstrated that infection led decrease in lymphocytes (lymphopenia), attributed impaired proliferation apoptosis. The infiltration myeloid-derived suppressor cells (MDSCs) infected lungs was confirmed suppress T cell proliferation, leading lymphopenia. We further identified promotes tryptophan metabolism lungs, enhancing immunosuppressive activity MDSCs by inducing production enzyme IDO1. ex vivo inhibition experiment revealed L-kynurenine, product metabolism, inhibits T-cell induces apoptosis, suppressing mediated responses against bacteria. Importantly, when knocked out Ido1 gene or inhibited IDO1 expression using specific inhibitor 1-MT mice, observed significant enhancement . These highlight role suggest promising immunotherapeutic approach inhibiting combat infectious diseases.

Язык: Английский

Процитировано

0