Frailty, polypharmacy, malnutrition, chronic conditions, and quality of life in the elderly: Large population-based study (Preprint)

JMIR Public Health and Surveillance, Год журнала: 2024, Номер 10, С. e50617 - e50617

Опубликована: Авг. 15, 2024

Background Aging, a significant public health issue, is associated with multiple concurrent chronic diseases and aging-related conditions (geriatric syndromes). Objective This study aims to investigate the impact of age on geriatric syndromes intercorrelations between quality life (QoL) in older adults (aged ≥65 years) at population level. Methods A large representative sample was randomly selected from county China, Feidong, 17 towns 811,867 residents. Multiple conditions, (frailty, polypharmacy, malnutrition), QoL were assessed compared. Associations demographic information using multivariable-adjusted logistic regression. Intercorrelations age, syndromes, investigated both correlation analysis restricted cubic splines–based dose-response analysis. Results Older comprised 43.42% (3668/8447) entire population. The prevalence frailty, premalnutrition or malnutrition, impaired (median 73, IQR 69-78 years; 1871/3668, 51% men) 8.26% (303/3668), 15.59% (572/3668), 3.22% (118/3668), 10.8% (396/3668), respectively. Different sex subgroups mostly had similar (except that frailty occurred more often age). Premalnutrition malnutrition lower frequency obesity higher constipation, polypharmacy diabetes constipation hernia, hypertension, diabetes, physical disability, constipation. Mini Nutritional Assessment–Short Form, Groningen Frailty Indicator, EQ-5D-5L scores, as well number medications used, predicted each other QoL. Impaired polypharmacy. At 1.5-year follow-up, linked baseline, baseline. Causal mediation analyses showed mediated link worse Conclusions In this population-based adults, ≥1 syndromes. Geriatric intercorrelated with, predictive of, QoL; causal relationships existed QoL, being mediators. findings might be biased by residual confounding factors. It important perform personalized syndrome assessments stratified condition; active prevention intervention for, any help reduce others improve

Язык: Английский

Drug-induced Acute Kidney Injury: A Clinico-etiological Study from a Tertiary Care Center in Northeast India

Journal of Nature and Science of Medicine, Год журнала: 2024, Номер unknown

Опубликована: Авг. 24, 2024

Abstract Background: Drug-induced acute kidney injury (AKI) poses a significant challenge in clinical practice, necessitating comprehensive understanding of its epidemiology and underlying mechanisms. This prospective study aimed to elucidate the clinico-etiological profile drug-induced AKI tertiary care center Northeast India evaluate patient outcomes. Methodology: Adults diagnosed with following drug exposure were enrolled this observational conducted from August 2022 January 2024 at Department Nephrology, Gauhati Medical College Hospital. Demographic data, characteristics, offending pharmaceutical agents, histopathological patterns, outcomes meticulously documented. Results: We studied 105 participants (mean age: 45 ± 10 years, 56.2% male) experiencing AKI. Antimicrobials (24%), nonsteroidal anti-inflammatory drugs (NSAIDs) (21%), chemotherapeutic agents (19%) common causes, leading predominantly interstitial nephritis (58%) renal tubular epithelial cell (30%). Despite challenges, 73% fully recovered, 2% mortality rate. Age (odds ratio [OR]: 1.35, 95% confidence interval [CI]: 1.12–1.63, P = 0.002), male gender (OR: 1.84, CI: 1.09–3.11, 0.022), diabetes 2.21, 1.28–3.82, 0.005), smoking 1.92, 1.06–3.48, 0.031), antimicrobial use 3.68, 2.14–6.32, < 0.001), NSAID 2.77, 1.56–4.92, 1.57, 1.10–2.22, 0.001) risk factors. Conclusion: highlights India, emphasizing antimicrobials, NSAIDs, chemotherapeutics as major contributors. high prevalence, most patients stressing early recognition careful medication management. Age, gender, comorbidities play critical roles, warranting targeted interventions vigilant pharmacovigilance mitigate burden effectively.

Язык: Английский