Ultrasonic renal length as an indicator of renal fibrosis severity in non-diabetic patients with chronic kidney disease DOI Creative Commons

Ziman Chen,

Jun Jiang, Simon Takadiyi Gunda

и другие.

Clinical and Experimental Nephrology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Abstract Background Debate continues regarding the potential of ultrasonic renal length to serve as an indicator for evaluating advancement fibrosis in chronic kidney disease (CKD). This study investigates independent association between and non-diabetic CKD patients assesses its diagnostic performance. Methods From April 2019 December 2021, 144 diagnosed with who underwent a ultrasound examination biopsy were prospectively enrolled. Patients categorized into mild group ( n = 70) moderate-severe 74) based on extent fibrotic involvement. Ultrasonic was measured from pole-to-pole coronal plane. A receiver operating characteristic (ROC) curve, multivariable logistic regression analysis, generalized additive model performed. Results negative linear correlation found risk. Each centimeter increase decreased odds by 38% (OR: 0.62; 95% CI 0.41–0.93; P 0.020). After adjusting confounders, relationship persisted 0.58; 0.33–1.00; 0.048). However, presented limited discrimination ability distinguishing degrees while controlling key confounding factors, yielding area under ROC curve only 0.58 (95% 0.45–0.70). Conclusion While inverse exists risk having patients, alone is insufficient diagnosing severity, underscoring need additional parameters assessment.

Язык: Английский

Impact of SARS-CoV-2 Infection on Erythropoietin Resistance Index in Hemodialysis Patients DOI Creative Commons
Guido Gembillo, Luca Soraci,

Luigi Peritore

и другие.

Geriatrics, Год журнала: 2025, Номер 10(2), С. 33 - 33

Опубликована: Фев. 24, 2025

Background/Objectives: Hemodialysis (HD) patients with advanced chronic kidney disease (CKD) are highly vulnerable to complications from SARS-CoV-2 infection. Anemia management in this population is complex, particularly due erythropoietin resistance, which may be exacerbated by COVID-19-related inflammation. To aim, small-scale retrospective study, we investigated trends the resistance index (ERI) over time and without Methods: This single-center study included 25 HD patients, divided into two groups: 15 a history of infection (CoV2 group) 10 (nonCoV2 group). The ERI was assessed four visits, 70–100-day intervals between them. Linear mixed models were used evaluate factors associated changes. Results: Patients CoV2 group exhibited significantly higher increases T1 (baseline) T2 (post-infection) compared nonCoV2 (median ΔERI: +4.65 vs. −0.27, p < 0.001). During T2–T4 recovery period, demonstrated delayed but substantial decline ERI, converging baseline levels T4. Male sex hemoglobin negatively ERI. Conclusions: induces transient significant likely inflammation disrupted erythropoiesis. Tailored anemia strategies, including potential use hypoxia-inducible factor stabilizers, warranted. Larger, multicenter studies needed validate these findings improve treatment protocols.

Язык: Английский

Процитировано

0
Ultrasonic renal length as an indicator of renal fibrosis severity in non-diabetic patients with chronic kidney disease DOI Creative Commons

Ziman Chen,

Jun Jiang, Simon Takadiyi Gunda

и другие.

Clinical and Experimental Nephrology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Abstract Background Debate continues regarding the potential of ultrasonic renal length to serve as an indicator for evaluating advancement fibrosis in chronic kidney disease (CKD). This study investigates independent association between and non-diabetic CKD patients assesses its diagnostic performance. Methods From April 2019 December 2021, 144 diagnosed with who underwent a ultrasound examination biopsy were prospectively enrolled. Patients categorized into mild group ( n = 70) moderate-severe 74) based on extent fibrotic involvement. Ultrasonic was measured from pole-to-pole coronal plane. A receiver operating characteristic (ROC) curve, multivariable logistic regression analysis, generalized additive model performed. Results negative linear correlation found risk. Each centimeter increase decreased odds by 38% (OR: 0.62; 95% CI 0.41–0.93; P 0.020). After adjusting confounders, relationship persisted 0.58; 0.33–1.00; 0.048). However, presented limited discrimination ability distinguishing degrees while controlling key confounding factors, yielding area under ROC curve only 0.58 (95% 0.45–0.70). Conclusion While inverse exists risk having patients, alone is insufficient diagnosing severity, underscoring need additional parameters assessment.

Язык: Английский

Процитировано

0