Recent Developments and Challenges in Molecular-Targeted Therapy of Non-Small-Cell Lung Cancer

Journal of Environmental Pathology Toxicology and Oncology, Год журнала: 2022, Номер 42(1), С. 27 - 50

Опубликована: Июнь 17, 2022

Treatment of lung cancer with conventional therapies, which include radiation, surgery, and chemotherapy results in multiple undesirable adverse or side effects. The major clinical challenge developing new drug therapies for is resistance, involves mutations disturbance various signaling pathways. Molecular abnormalities related to epidermal growth factor receptor (EGFR), v-Raf murine sarcoma viral oncogene homolog B1 (B-RAF) Kirsten rat virus (KRAS) mutations, translocation the anaplastic lymphoma kinase (ALK) gene, mesenchymal-epithelial transition (MET) amplification have been studied overcome resistance develop non-small cell (NSCLC). But, inevitable development presents limits benefits drugs. Here, we review current progress molecularly targeted concerning six biomarkers: EGFR, ALK, MET, ROS-1, KRAS, B-RAF NSCLC treatment.

Язык: Английский

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The multifaceted roles of matrix metalloproteinases in lung cancer

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Сен. 12, 2023

Background Though the matrix metalloproteinases (MMPs) are widely investigated in lung cancer (LC), however, almost no review systematically clarify their multi-faced roles LC. Methods We expression of MMPs and effects on survival patients with LC, resistance mechanisms anti-tumor therapy, regulatory networks involved, function inducing CSCLs, MMPs-related tumor immunity, MMP polymorphisms risk Results High was mainly related to poor survival, high clinical stages metastasis. Role LC multi-faced. involved drug resistance, induced participated immunity. Besides, may increase Conclusions might be promising targets restore immune response enhance killing nature cells

Язык: Английский

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Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway

Biomolecules, Год журнала: 2020, Номер 10(4), С. 502 - 502

Опубликована: Март 26, 2020

Oral squamous cell carcinoma is the sixth most common type of cancer globally, which associated with high rates cancer-related deaths. Metastasis to distant organs main reason behind worst prognostic outcome oral cancer. In present study, we aimed at evaluating effects a natural plant flavonoid, luteolin-7-O-glucoside, on migration and invasion. The study findings showed that in addition preventing proliferation, luteolin-7-O-glucoside caused significant reduction Mechanistically, metastasis by reducing p38 phosphorylation downregulating matrix metalloproteinase (MMP)-2 expression. Using inhibitor, SB203580, proved exerts anti-migratory suppressing p38-mediated increased expression MMP-2. This first demonstrate inhibits invasion regulating MMP-2 extracellular signal-regulated kinase pathway human cell. identifies as potential anti-cancer candidate can be utilized clinically for improving prognosis.

Язык: Английский

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XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a

Cancer Letters, Год журнала: 2021, Номер 503, С. 197 - 212

Опубликована: Янв. 23, 2021

Язык: Английский

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Promising Combinatorial Therapeutic Strategies against Non-Small Cell Lung Cancer

Cancers, Год журнала: 2024, Номер 16(12), С. 2205 - 2205

Опубликована: Июнь 12, 2024

Non-small cell lung cancer (NSCLC) presents a complex and diverse disease, exhibiting variations at individuals' cellular histological levels. This complexity gives rise to different subtypes genetic mutations, posing challenges for accurate diagnosis effective treatment. Nevertheless, continuous progress in medical research therapies is continually shaping the landscape of NSCLC management. The treatment has undergone significant advancements recent years, especially with emergence targeted that have shown remarkable efficacy patients actionable mutations. ushered era personalized medicine treatment, improvements molecular immunohistochemical techniques contributing enhanced progression-free survival. review focuses on latest progress, challenges, future directions developing NSCLC, including tyrosine kinase inhibitors (TKIs), DNA-damaging agents, immunotherapy regimens, natural drug therapy, nanobodies. Furthermore, randomized studies demonstrated overall survival receiving therapies.

Язык: Английский

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Inhibitory potentials of <i>Ageratum conyzoides</i> L. and <i>Tridax procumbens</i> L. ethanolic leaf extracts against multidrug-resistant bacteria (MDRB) from cancer patients

Journal of Clinical and Experimental Investigations, Год журнала: 2025, Номер 16(2), С. em00842 - em00842

Опубликована: Март 17, 2025

Cancer and its associated treatments often compromise the immune system, predisposing patients to opportunistic infections, including those caused by multidrug-resistant bacteria (MDRB). This study investigated resistance patterns of bacterial pathogens isolated from cancer evaluated antibacterial efficacy ethanolic leaf extracts <i>Ageratum conyzoides</i> <i>Tridax procumbens</i> at a concentration 200 mg/mL against these MDRB pathogens. A retrospective analysis was conducted on data attending tertiary healthcare facility. Bacterial isolates were identified blood samples screened for antibiotic susceptibility patterns. The <i>A. <i>T. assessed as potential alternative therapy. revealed that breast most prevalent type (38%) among patient population (n = 160). In addition, common included <i>Escherichia coli</i> (12 isolates), <i>Klebsiella pneumoniae</i> (15), <i>Streptococcus (9), <i>Shigella dysenteriae</i> (10), <i>Staphylococcus aureus</i> (12), aerogenes</i> (6), <i>Salmonella typhi</i> (7). These exhibited significant multidrug conventional antibiotics. For instance, showed high cotrimoxazole (83%), ceftazidime (67%), erythromycin (75%), cefuroxime whilst&nbsp; retaining gentamycin. Conversely, demonstrated inhibitory zones ranging 8.26 ± 0.15 mm 25.22 0.83 8.30 0.20 23.22 mm, respectively MDR evaluated. Findings susceptible (25.22 mm), whilst notable activity Additionally, combination ofloxacin synergistic effects typhi</i>. underscores vulnerability infections highlights sources agents. Hence, further purification characterization are recommended developing effective therapeutic options

Язык: Английский

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Sea Hare Hydrolysate-Induced Reduction of Human Non-Small Cell Lung Cancer Cell Growth through Regulation of Macrophage Polarization and Non-Apoptotic Regulated Cell Death Pathways

Cancers, Год журнала: 2020, Номер 12(3), С. 726 - 726

Опубликована: Март 19, 2020

Sea hare-derived compounds induce macrophage activation and reduce asthmatic parameters in mouse models of allergic asthma. These findings led us to study the role sea hare hydrolysates (SHH) cancer pathophysiology. SHH treatment-induced M1 RAW264.7 cells, peritoneal macrophages, THP-1 as did lipopolysaccharide (LPS) (+ INF-γ), whereas reduced interleukin (IL)-4 (+IL-13)-induced M2 polarization. In addition, treatment inhibited actions which have anticancer pro-cancer effects, respectively, non-small cell lung cells (A549 HCC-366) tumor-associated macrophages (TAMs). Furthermore, induced G2/M phase arrest death A549 cells. also downregulated STAT3 down-regulation was recovered by colivelin, a activator. SHH-induced reduction polarization tumor growth blocked colivelin treatment. not occur manner apoptotic signaling pathways, while pattern mediated through pyroptosis/necroptosis, causes membrane rupture, formation vacuoles bleb, caspase-1, secretion IL-1β SHH-treated However, combination caspase-1 activation. Z-YVAD-FMK necrostatin-1, pyrotosis necroptosis inhibitors, attenuated SHH's effect on viability Taken together, showed effects cytotoxic regulatory were non-apoptotic regulated pathways under inhibition. results suggest that may be offered potential remedy for immunotherapy.

Язык: Английский

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A review of protein-protein interaction and signaling pathway of Vimentin in cell regulation, morphology and cell differentiation in normal cells

Journal of Receptors and Signal Transduction, Год журнала: 2022, Номер 42(5), С. 512 - 520

Опубликована: Март 16, 2022

The Vimentin intermediate filament (VIF) is an essential cytoskeleton component. It shows dynamically changing expression patterns throughout various phases of the differentiation process, suggesting that protein physiologically important. Vimentin's functions have recently been clear, so Vimentin-deficient animals was described as a change morphology and signaling pathway. Recent research has discovered many vital roles for were previously unknown. VIF emerges organizer proteins involved in movement cell signaling. highly dynamic complicated phosphorylation seems to be regulator mechanism activities. Changes IF are often linked with cancer progression, especially those leading enhanced invasion cellular migration. This review will discuss function filaments normal physiology, adhesion structures, shape, pathways. genes interaction gene network discussed more studies. However, aimed at understanding different cascades interactions might offer novel methods creating therapeutic medicines. Enrichr GEO datasets used ontology (GO) pathway enrichment analyses. STRING online predict functional connections proteins-proteins, followed by Cytoscape analysis find master genes. revealed eight genes, Fas, Casp8, Casp6, Fadd, Ripk1, Des, Tnnc2, Tnnt3, required protein-protein differentiation.

Язык: Английский

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Natural products combating EGFR-TKIs resistance in cancer

European Journal of Medicinal Chemistry Reports, Год журнала: 2025, Номер unknown, С. 100251 - 100251

Опубликована: Фев. 1, 2025

Язык: Английский

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Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses

Cell Discovery, Год журнала: 2021, Номер 7(1)

Опубликована: Ноя. 2, 2021

Abstract Signaling cascades provide integrative and interactive frameworks that allow the cell to respond signals from its environment and/or within itself. The dynamic regulation of mammalian signaling pathways is often modulated by protein post-translational modifications (PTMs). ADP-ribosylation a PTM catalyzed ADP-ribosyltransferases manifests as mono- (MARylation) or poly- (PARylation) depending on addition one multiple ADP-ribose units substrates. has recently emerged an important regulator impacts plethora cellular processes, including many intracellular events. Here, we overview interplay between diphtheria toxin-like ADP-ribosyltransferase (ARTD) family members five selected (including NF-κB, JAK/STAT, Wnt-β-catenin, MAPK, PI3K/AKT), which are frequently described control be controlled how these interactions impact responses.

Язык: Английский

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