Diagnostic value of a lactylation-related gene signature in hepatocellular carcinoma

Translational Cancer Research, Год журнала: 2025, Номер 14(1), С. 296 - 312

Опубликована: Янв. 1, 2025

The occurrence rate of liver cancer is increasing in recent years. significance lactylation tumor cells should not be neglected. This study aimed to discover a gene signature related that can used for diagnostic applications. Data were downloaded from Cancer Genome Atlas (TCGA), GSE14520, GSE84402, and GSE62232 datasets. Differential analysis random forest performed hepatocellular carcinoma (HCC). Receiver operating characteristic (ROC) curve was evaluate efficiency, logistic regression established obtain the risk score equation. Besides, expression genes identified by TCGA database verified real-time quantitative polymerase chain reaction (RT-PCR). In order analyze prognostic performance, patients diagnosed with HCC stratified into either high or low categories based on median score. addition, immunotherapy drug sensitivity groups assessed. performance model validated Gene Expression Omnibus (GEO) dataset. had worse outcomes than those database. ROC curves showed characteristics lactylation-related good predictive capability. Furthermore, we developed nomogram patients, utilizing data resources TCGA. Finally, terms assessing potency group lower Tumor Immune Dysfunction Exclusion (TIDE) score, indicating response immunotherapy. Our identification associated presents promising avenue development targeted immunotherapeutic strategies.

Язык: Английский

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Protein succinylation mechanisms and potential targeted therapies in urinary disease

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111744 - 111744

Опубликована: Март 1, 2025

Язык: Английский

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Astragaloside IV as a promising therapeutic agent for liver diseases: current landscape and future perspectives

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 23, 2025

Astragaloside IV (C 41 H 68 O 14 , AS-IV) is a naturally occurring saponin isolated from the root of Astragalus membranaceus widely used traditional Chinese botanical drug in medicine. In recent years, AS-IV has attracted considerable attention for its hepatoprotective properties, which are attributed to low toxicity as well anti-inflammatory, antioxidant and antitumour effects. Numerous preclinical studies have demonstrated potential prevention treatment various liver diseases, including multifactorial injury, metabolic-associated fatty disease, fibrosis cancer. Given promising growing interest research, this review provides comprehensive summary current state research on effects AS-IV, based literature available databases such CNKI, PubMed, ScienceDirect, Google Scholar Web Science. The mechanisms multifaceted, encompassing inhibition inflammatory responses, reduction oxidative stress, improvement insulin leptin resistance, modulation gut microbiota, suppression hepatocellular carcinoma cell proliferation induction tumour apoptosis. Notably, key molecular pathways involved these include Nrf2/HO-1, NF-κB, NLRP3/Caspase-1, JNK/c-Jun/AP-1, PPARα/FSP1 Akt/GSK-3β/β-catenin. Toxicity indicate that high level safety. addition, discusses sources, physicochemical challenges development clinical application providing valuable insights into agent pharmaceutical nutraceutical industries.

Язык: Английский

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Precision Strike Strategy for Liver Diseases Trilogy with Xiao-Chai-Hu Decoction: A Meta-Analysis with Machine Learning

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156796 - 156796

Опубликована: Апрель 1, 2025

Язык: Английский

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